A Scoping Review of Disposal of Unused Medicines in Take-Back Programs


Mufti Alifia Rahmadani(1), Susi Ari Kristina(2*)

(1) Master Program in Pharmacy Management, Faculty of Pharmacy, Gadjah Mada University
(2) Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author


Unused medicines in the household cause many problems. Medicines take-back programs were established to prevent inappropriate medicines disposal, abuse, accidental poisoning, and help reduce the number of unused medicines in households. A literature search using the keywords “unused AND medicine”, “disposal AND unused AND medicine”, “reasons AND medicine AND disposal”, “medicine AND take-back program” and “cost AND medicine AND take-back program” in PubMed, Science Direct, Scopus and Google Scholar. Articles published in 2010 – 2020 in English report the medicine take-back program with the number of medicines and/or reasons for the return and/or economic value of medicines collected in the medicines take-back program. A total of 16 articles were included in the criteria for this systematic review. Medicines take-back program was majority-owned in the US (69%). Two programs focus on returning controlled medicines. Gastrointestinal, respiratory, cardiovascular, antimicrobial and non-narcotic analgesic were the most common of all medicines returned. The expired medicine and treatment discontinuation by (doctors/prescribers) were the most reason medicine was returned to the medicines take-back program. The total cost of all medicines returned topped $1,118,020. Medicines take-back program was an essential solution to the inappropriate medicine disposal problem. Good coordination was required between the government and other authorities.This medicine take-back issues can help solve the problems of medicine use, storage, and disposal that lead to the country's economy.


Program Pengembalian Obat; Pembuangan; Biaya; Pemborosan; Alasan

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  1. Kristina SA, Wiedyaningsih C, Cahyadi A, Ridwan BA. A survey on medicine disposal practice among households in Yogyakarta. Asian J Pharm. 2018;12(3):S955–8.
  2. Law A V., Sakharkar P, Zargarzadeh A, Tai BWB, Hess K, Hata M, et al. Taking stock of medication wastage: Unused medications in US households. Vol. 11, Research in Social and Administrative Pharmacy. 2015. p. 571–8.
  3. Stoddard KI, Hodge V, Maxey G, Tiwari C, Cready C, Huggett DB. Investigating Research Gaps of Pharmaceutical take back Events: An Analysis of take back Program Participants’ Socioeconomic, Demographic, and Geographic Characteristics and the Public Health Benefits of take back Programs. Environ Manage [Internet]. 2017;59(6):871–84. Available from: http://dx.doi.org/10.1007/s00267-017-0834-3
  4. Abushanab AS, Sweileh WM, Wazaify M. Storage and wastage of drug products in Jordanian households: A cross-sectional survey. Int J Pharm Pract. 2013;21(3):185–91.
  5. Ridwan BA. Praktik Pembuangan Obat Di Kalangan Rumah Tangga Kota Yogyakarta dan Evaluasi Dampak Ekonomi. Universitas Gadjah Mada; 2018.
  6. Yang C, Doshi M, Mason N. Analysis of Medications Returned During a Medication Take-Back Event. Pharmacy. 2015;3(3):79–88.
  7. Kelly F, McMillan S, Spinks J, Bettington E, Wheeler AJ. “You don’t throw these things out:” an exploration of medicines retention and disposal practices in Australian homes. BMC Public Health. 2018;18(1):1–12.
  8. El-hamamsy M, El-hamamsy APM, Pharmacy F. Unused Medications : How Cost and How Disposal of in Cairo , Egypt. Int J Pharm Stud Res. 2011;2(1):21–7.
  9. West LM, Diack L, Cordina M, Stewart D. A systematic review of the literature on ‘medication wastage’: an exploration of causative factors and effect of interventions. Int J Clin Pharm. 2014;36(5):873–81.
  10. Ma CS, Batz F, Juarez DT air., Ladao LC. Drug take back in Hawai’i: partnership between the University of Hawai’i Hilo College of Pharmacy and the Narcotics Enforcement Division. Hawaii J Med Public Health. 2014;73(1):26–31.
  11. Perry LA, Shinn BW, Stanovich J. Quantification of ongoing community-based medication take-back program. J Am Pharm Assoc [Internet]. 2014;54(3):275–9. Available from: http://dx.doi.org/10.1331/JAPhA.2014.13143
  12. Gray-Winnett MD, Davis CS, Yokley SG, Franks AS. From dispensing to disposal: The role of student pharmacists in medication disposal and the implementation of a take-back program. J Am Pharm Assoc [Internet]. 2010;50(5):613–8. Available from: http://dx.doi.org/10.1331/JAPhA.2010.09197
  13. Stewart H, Malinowski A, Ochs L, Jaramillo J, McCall K, Sullivan M. Inside Maine’s medicine cabinet: Findings from the Drug Enforcement Administration’s medication take-back events. Am J Public Health. 2015;105(1):e65–71.
  14. Jaramillo-Stametz JE, Stewart H, Ochs L, Payne K. Multi-state medication take back initiative: Controlled substances collected from 2011 to 2015. J Subst Use [Internet]. 2018;23(1):36–42. Available from: https://doi.org/10.1080/14659891.2017.1337821
  15. Fleming E, Proescholdbell S, Sachdeva N, Alexandridis AA, Margolis L, Ransdell K. North Carolina’s Operation Medicine Drop: Results From One of the Nation’s Largest Drug Disposal Programs. N C Med J. 2016;77(1):59–62.
  16. Moustarah F, Desai JP, Blebea J. Removing abuse-prone prescription medication from fueling the national opioid crisis through community engagement and surgeon leadership: results of a local drug take-back event. Surg Open Sci [Internet]. 2020;2(1):34–41. Available from: https://doi.org/10.1016/j.sopen.2019.09.002
  17. Shealy KM, Ritter MS, Wyatt AS, Eagerton DH. Trends in potentially abused medications returned during medication take-back days. J Am Pharm Assoc [Internet]. 2019;59(4):575–8. Available from: https://doi.org/10.1016/j.japh.2019.04.005
  18. Bergen PJ, Hussainy SY, George J, Kong DCM, Kirkpatrick CMJ. Safe disposal of prescribed medicines. Aust Prescr. 2015;38(3):90–2.
  19. Vella V, West L-M. Analysis of Disposed Unused Medications at a Village Community Pharmacy. Vol. 7, Pharmacy. 2019. p. 45.
  20. Gracia-Vásquez SL, Ramírez-Lara E, Camacho-Mora IA, Cantú-Cárdenas LG, Gracia-Vásquez YA, Esquivel-Ferriño PC, et al. An analysis of unused and expired medications in Mexican households. Int J Clin Pharm. 2014;37(1):121–6.
  21. Yang SL, Tan SL, Goh QL, Liau SY. Utilization of Ministry of Health Medication Return Programme, Knowledge and Disposal Practice of Unused Medication in Malaysia. J Pharm Pract Community Med. 2018;4(1):07–11.
  22. Akici A, Aydin V, Kiroglu A. Assessment of the association between drug disposal practices and drug use and storage behaviors. Saudi Pharm J [Internet]. 2018;26(1):7–13. Available from: https://doi.org/10.1016/j.jsps.2017.11.006
  23. Martin K, Martin N, Hanzooma H, Davies K, Christabel NH. Assessment of household knowledge, attitude and practices on disposal methods of expired and unused medicines among residents of Lusaka City, Zambia. African J Pharm Pharmacol. 2020;14(7):221–8.
  24. Kachhap S, Singh GK, Soreng EA, Beck RK, Kumar U. A study to assess the knowledge and awareness regarding safe disposal of pharmaceutical wastes among 2nd year medical and para-medical students in a tertiary care teaching hospital in North India. Int J Basic Clin Pharmacol. 2020;9(3):493.
  25. Tanabe P, Paice JA, Stancati J, Fleming M. How Do Emergency Department Patients Store and Dispose of Opioids After Discharge? A Pilot Study. J Emerg Nurs. 2012;38(3):273–9.
  26. Lystlund S, Stevens E, Planas LG, Marcy TR. Patient participation in a clinic-based community pharmacy medication take-back program. J Am Pharm Assoc [Internet]. 2014;54(3):280–4. Available from: http://dx.doi.org/10.1331/JAPhA.2014.13132
  27. Dijk KH and L Van. The world medicines situation: rational use of medicines. World Med Situat. 2011;2(2):24–30.
  28. Auta A, Banwat SB, Sariem CN, Shalkur D, Nasara B, Atuluku MO. Medicines in pharmacy students’ residence and self-medication practices. J Young Pharm [Internet]. 2012;4(2):119–23. Available from: http://dx.doi.org/10.4103/0975-1483.96627

DOI: https://doi.org/10.22146/jmpf.61343

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