The Effect of Based Services Medication Therapy Management on Treatment Adherence and Quality of Life of Diabetes Mellitus Patients
Rachma Malina(1), Nanang Munif Yasin(2*), Chairun Wiedyaningsih(3)
(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(2) Fakultas Farmasi, Universitas Gadjah Mada
(3) Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Diabetes mellitus is a chronic metabolic disorder that is characterized by hyperglycemia. Diabetes mellitus need appropriate therapeutic management, because it can cause complications. On of the services that can do to improve diabetes control is Medication Therapy Management (MTM). MTM is a new service that will help pharmacist to improve patient adherence and quality of life. This study aims to determine the effect of based services MTM on treatment adherence and quality of life in patients with diabetes mellitus. This study was an experimental study using a quasi-experimental with one group pretest and posttest design which was conducted in Tegalrejo, Jetis and Gedontengen Health Center Yogyakarta City. Variables measured were medication adherence using the Morisky-Green Levine Medication Adherence Scale (MGLS) questionnaire and quality of life using Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) before and after MTM services. The effect of MTM on medication adherence was analyzed using Wilcoxon test and the effect of MTM on quality of life using Paired T-Test. The patients participate in this study were 20 people, with average score of adherences before application of MTM was 2.20±0.410 to 1.80±0.616 after the application of MTM (P=0.005) and the average of the patient's quality of life was 73.82±7.918, increased to 76.42±5,623 after MTM service (P=0.033). Statistically mean, there is a difference in adherence and quality of life before and after MTM services. Therefore, it can be concluded that MTM-based services performed by pharmacists have a significant effect on improving medication adherence and quality of life for DM patients. Moreover, it can facilitate monitoring patient therapy, and identification of problems related to the treatment.
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- Pinto SL, Kumar J, Partha G, Bechtol RA. Pharmacist-provided Medication Therapy Management (MTM) program impacts outcomes for employees with diabetes. Popul Health Manag. 2014;17(1):21-27. doi:10.1089/pop.2012.0124
- Bindu Murali A, Boban B, Karoor Shanmughan A, Marimuthu K, Ramakrishnaneelatha A, Xavier A. Medication therapy management (MTM): An innovative approach to improve medication adherence in diabetics. Drug Metab Pers Ther. 2016;31(3):151-155. doi:10.1515/dmpt-2016-0016
- Wild S, Bchir MB, Roglic G, et al. Global Prevalence of Diabetes Estimates for the Year 2000 and Projections for 2030.; 2004. http://care.diabetesjournals.
- RI K. HARI DIABETES SEDUNIA TAHUN 2018 Definisi Diabetes.; 2019.
- Dinas Kesehatan. 2018_DIY_profil-KESEHATAN-NARASI.; 2018.
- Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4-14. doi:10.1016/j.diabres.2009.10.007
- Bluml BM. Definition of medication therapy management: Development of professionwide consensus. J Am Pharm Assoc. 2005;45(5):566-572. doi:10.1331/1544345055001274
- Burns A. Medication therapy management in pharmacy practice: Core elements of an MTM service model (version 2.0). J Am Pharm Assoc. 2008;48(3):341-353. doi:10.1331/JAPhA.2008.08514
- Viswanathan M, Kahwati LC, Golin CE, et al. Medication therapy management interventions in outpatient settings: A systematic review and meta-analysis. JAMA Intern Med. 2015;175(1):76-87. doi:10.1001/jamainternmed.2014.5841
- Erku DA, Ayele AA, Mekuria AB, Belachew SA, Hailemeskel B, Tegegn HG. The impact of pharmacist-led medication therapy management on medication adherence in patients with type 2 diabetes mellitus: A randomized controlled study. Pharm Pract (Granada). 2017;15(3). doi:10.18549/PharmPract.2017.03.1026
- Presetiawati I, Andrajati R, Sauriasari R. Effectiveness of a medication booklet and counseling on treatment adherence in type 2 diabetes mellitus patients. Int J Appl Pharm. 2017;9:27-31. doi:10.22159/ijap.2017.v9s1.24_29
- Septiar1 HE, Utami2 P. Pengaruh Konseling Farmasis Terhadap Kualitas Hidup dan Kadar Gula Darah pada PAasien Diabetes Mellitus Tipe 2 di Puskesmas Gedongtengen Periode Maret-Mei 2014. J Farm Sains dan Prakt. 2015;1(1).
- Wang Y, Lee J, Toh MPHS, Tang WE, Ko Y. Validity and reliability of a self-reported measure of medication adherence in patients with Type2 diabetes mellitus in Singapore. Diabet Med. 2012;29(9). doi:10.1111/j.1464-5491.2012.03733.x
- Al-Qazaz HK, Hassali MA, Shafie AA, Sulaiman SA, Sundram S, Morisky DE. The eight-item Morisky Medication Adherence Scale MMAS: Translation and validation of the Malaysian version. Diabetes Res Clin Pract. 2010;90(2):216-221. doi:10.1016/j.diabres.2010.08.012
- Sakthong P, Chabunthom R, Charoenvisuthiwongs R. Psychometric Properties of the Thai Version of the 8-item Morisky Medication Adherence Scale in Patients with Type 2 Diabetes. Ann Pharmacother. 2009;43(5):950-957. doi:10.1345/aph.1L453
- Shalansky SJ, Levy AR, Ignaszewski AP. Self-Reported Morisky Score for Identifying Nonadherence with Cardiovascular Medications. Ann Pharmacother. 2004;38(9):1363-1368. doi:10.1345/aph.1E071
- Erickson SR, Coombs JH, Kirking DM, Azimi AR. Compliance from Self-Reported versus Pharmacy Claims Data with Metered-Dose Inhalers. Ann Pharmacother. 2001;35(9):997-1003. doi:10.1345/aph.10379
- Tzeng JI, Chang C-C, Chang H-J, Lin C-C. Assessing Analgesic Regimen Adherence with the Morisky Medication Adherence Measure for Taiwanese Patients with Cancer Pain. J Pain Symptom Manage. 2008;36(2):157-166. doi:10.1016/j.jpainsymman.2007.10.015
- Hartati T. Kualitas hidup penderita dm tipe 2 perbandingan antara penderita kadar gula darah terkendali dan tidak terkendali. Published online 2003.
- Beyhaghi H, Reeve BB, Rodgers JE, Stearns SC. Psychometric Properties of the Four-Item Morisky Green Levine Medication Adherence Scale among Atherosclerosis Risk in Communities (ARIC) Study Participants. Value Heal. 2016;19(8):996-1001. doi:10.1016/j.jval.2016.07.001
- Adikusuma W, Farmasi A, Banjarmasin I, Perwitasari DA, Supadmi W. PENGUKURAN KUALITAS HIDUP PASIEN DIABETES MELITUS TIPE 2 YANG MENDAPAT ANTIDIABETIK ORAL DI RUMAH SAKIT PKU MUHAMMADIYAH BANTUL YOGYAKARTA QUALITY OF LIFE MEASUREMENT OF TYPE 2 DIABETIC MELLITUS PATIENTS WHO GETS ORAL ANTI DIABETIC IN PKU MUHAMMADIYAH BANTUL YOGYAKARTA. Vol 1.; 2016.
- Sinuraya RK, Oktrina A, Handayani NK, Destiani DP, Puspitasari IM. Pelayanan Farmasi Klinis Meningkatkan Kontrol Gula Darah Pasien Diabetes Melitus. Indones J Clin Pharm. 2019;8(4):271. doi:10.15416/ijcp.2019.8.4.271
- Rokhman MR, Darakay CN, Raditya R. Pengaruh Pemberian Home Care Oleh Apoteker Pada Pasien Diabetes Melitus. Published online 2015.
- Katadi S, Andayani TM, Endarti D. The Correlation of Treatment Adherence with Clinical Outcome and Quality of Life in Patients with Type 2 Diabetes. J Manaj DAN PELAYANAN Farm (Journal Manag Pharm Pract. 2019;9(1):19. doi:10.22146/jmpf.42927
- Yuwindry I, Wiedyaningsih C, Widodo GP. Pengaruh Pengetahuan Terhadap Kualitas Hidup Dengan Kepatuhan Penggunaan Obat Sebagai Variabel Antara Pada Pasien DM. 2016;6.
- World Health Organization. Global Report on Diabetes. WHO press; 2016.
- Mauvais-Jarvis F, Manson JAE, Stevenson JC, Fonseca VA. Menopausal hormone therapy and type 2 diabetes prevention: Evidence, mechanisms, and clinical implications. Endocr Rev. 2017;38(3):173-188. doi:10.1210/er.2016-1146
- Shepard M. Postmenopausal Women with Type 2 Diabetes: Better Glycemic Control with HT. NEJM J Watch. Published online 2001.
- Tao X, Li J, Zhu X, et al. Association between socioeconomic status and metabolic control and diabetes complications: A cross-sectional nationwide study in Chinese adults with type 2 diabetes mellitus. Cardiovasc Diabetol. 2016;15(1). doi:10.1186/s12933-016-0376-7
- Ndefo UA, Aisha B;, Moultry M, Davis PN, Askew R. Provision of Medication Therapy Management by Pharmacists to Patients With Type-2 Diabetes Mellitus in a Federally Qualified Health Center. Vol 42.; 2017.
- Manju CS, Razak R, Chandni R, Athira B. PHARMACIST INTERVENTION IN MEDICATION ADHERENCE IN PATIENTS WITH TYPE II DIABETES MELLITUS. Int J Pharm Sci Res. 2016;7(1):358. doi:10.13040/IJPSR.0975-8232.7(1).358-62
- Shareef J, Fernandes J. Evaluating the Effect of Pharmacist’s Delivered Counseling on Medication Adherence and Glycemic Control in Patients with Diabetes Mellitus. J Diabetes Metab. 2016;07(03). doi:10.4172/2155-6156.1000654
- Butt M, Mhd Ali A, Bakry MM, Mustafa N. Impact of a pharmacist led diabetes mellitus intervention on HbA1c, medication adherence and quality of life: A randomised controlled study. Saudi Pharm J. 2016;24(1):40-48. doi:10.1016/j.jsps.2015.02.023
- Rasdianah N, Martodiharjo S, Andayani TM, Hakim L. The Description of Medication Adherence for Patients of Diabetes Mellitus Type 2 in Public Health Center Yogyakarta. Indones J Clin Pharm. 2016;5(4):249-257. doi:10.15416/ijcp.2016.5.4.249
- Adisa R, Alutundu MB, Fakeye TO. Factors contributing to nonadherence to oral hypoglycemic medications among ambulatory type 2 diabetes patients in Southwestern Nigeria. Pharm Pract. 2009;7(3):163-169. www.pharmacypractice.org
- Nanda OD, Wiryanto B, Triyono EA. Hubungan Kepatuhan Minum Obat Anti Diabetik dengan Regulasi Kadar Gula Darah pada Pasien Perempuan Diabetes Mellitus. Amerta Nutr. 2018;2(4):340. doi:10.20473/amnt.v2i4.2018.340-348
- Shams MEE, Barakat EAME. Measuring the rate of therapeutic adherence among outpatients with T2DM in Egypt. Saudi Pharm J. 2010;18(4):225-232. doi:10.1016/j.jsps.2010.07.004
- Kubais MN Al, Hassan NAGM, Shamsain MH. Assosiation Between Adherence to Diabetes Medication and Glycemic Control. Int J Res Dev Pharm Life Sci. 2015;5(1):1915-1920.
- Ainni AN. Studi Kepatuhan Pengobatan Penggunaan Obat Pada Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Jalan RSUD. Dr. Tjitrowardojo Purworejo. Published online 2017.
- Srikartika VM, Dwi Cahya A, Suci R, Hardiati W. Analisis Faktor yang Memengaruhi Kepatuhan Penggunaan Obat Pasien Diabetes Melitus Tipe 2. J Manaj dan Pelayanan Farm . 2016;6(3):205-212.
- Nagavi B, Adepu R, Rasheed A. Effect of patient counseling on quality of life in type-2 diabetes mellitus patients in two selected South Indian community pharmacies: A study. Indian J Pharm Sci. 2007;69(4):519. doi:10.4103/0250-474X.36937
- Wahyu Ningtyas D, Pudjo Wahyudi dr, Prasetyowati I. Analisis Kualitas Hidup Pasien Diabetes Melitus Tipe II Di RSUD Bangil Kabupaten Pasuruan (Analyze Quality of Life in Patients With Type II Diabetes Mellitus at Public Hospital of Bangil, Pasuruan).; 2013.
- Gautam Y, Sharma AK, Agarwal AK, Bhatnagar MK, Trehan RR. A cross-sectional study of QOL of diabetic patients at tertiary care hospitals in Delhi. Indian J Community Med. 2009;34(4):346-350. doi:10.4103/0970-0218.58397
- Redekop WK, Koopmanschap MA, Stolk RP, Rutten GEHM, Wolffenbuttel BHR, Niessen LW. Health-Related Quality of Life and Treatment Satisfaction in Dutch Patients With Type 2 Diabetes. Vol 25.; 2002.
- Issa B, Baiyewu O. Quality of Life of Patients with Diabetes Mellitus in a Nigerian Teaching Hospital. Hong Kong J Psychiatry. Published online 2000.
- Zyoud SH, Al-Jabi SW, Sweileh WM, et al. Relationship of treatment satisfaction to health-related quality of life among Palestinian patients with type 2 diabetes mellitus: Findings from a cross-sectional study. J Clin Transl Endocrinol. 2015;2(2):66-71. doi:10.1016/j.jcte.2015.03.002
- Javanbakht M, Abolhasani F, Mashayekhi A, Baradaran HR, Jahangiri noudeh Y. Health Related Quality of Life in Patients with Type 2 Diabetes Mellitus in Iran: A National Survey. PLoS One. 2012;7(8):e44526. doi:10.1371/journal.pone.0044526
DOI: https://doi.org/10.22146/jmpf.58052
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