Evaluasi Kualitas Hidup Pasien Kanker Serviks yang Mendapat Regimen Kemoterapi Cisplatin-Vinkristin-Bleomisin dan Carboplatin-Paklitaksel


Suwendar Suwendar(1*), Achmad Fudholi(2), Tri Murti Andayani(3), Herri S. Sastramihardja(4)

(1) Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengtahuan Alam, Universitas Islam Bandung
(2) Fakultas Farmasi, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(4) Faculty of Medicine, Universitas Padjajaran
(*) Corresponding Author


Cervical cancer is one type of cancer with a high prevalence in women. Quality of life of someone with cervical cancer will decrease. Quality of life can also decrease because of chemotherapy regimens. The purpose of this study was to evaluate the impact of cisplatin-vincristine-bleomycin and carboplatin-paclitaxel regimens on the quality of life of patients. Through this research how the difference in quality of life of patients with cervical cancer before and after chemotherapy could be known. Additionally, the  differences impact on the quality of life of the two regimens also were observed.  The study was conducted by using cross sectional design in hospitalization patients. Data were taken prospectively by conducting field observations. Measuring the quality of life was done using the EORTC QLQ-C30 questionnaire. Differences of domain values before and after chemotherapy in each regimen were analyzed by paired t-test (p <0.05). Quality of life difference between two regimens were analyzed by unpaired t test (p<0.05). The results showed that there was an increasing trend of the value of the functional domain, impairment of symptoms domain and an increase in the value of global health status domain after three cycles of chemotherapy of two regimens, except the symptoms of nausea and vomiting and loss of appetite that showed an increasing trend. Patients who received cisplatin-vincristine-bleomycin regimen showed a significant increasing (p = 0.009) in decreased of appetite symptom’s scores. No significant differences in the quality of life of patients who delivered chemotherapy regimen of cisplatin-vincristine-bleomycin compared to carboplatin-paclitaxel regimen.


cervical cancer, chemotherapy, quality of life, EORTC QLQ-C30

Full Text:



  1. Ricciardi, A., Langeron, N., Rossi, P.G., Raffaele, M., Cohet, C., Federici, A., Palazzo, F Incidence of Invasive Cervical Costs Associated with Its Management in Italy, Tumori. 2009; ISSN: 0300-8916. 95: 146-152.
  2. Perwitasari, D.A., Atthobari, J., Dwiprahasto, I., Hakimi, M., Gelderbion, H., Putter, H., Nortier, J.W.R., Guchelaar, H.J. and Kaptein, A.A. Translation and Validation of EORTC QLQ-C30 into Indonesian Version for cancer Patients in Indonesia. Jpn J Clin Oncol. 2011;41(4); 1-11.
  3. Krikeli, M., Ekonomopoulou, M.T., Tzitzikas, I., Goutzioulis, A., Mystakidou, K., Gombaki, K.P., Comparison of The Impact of Radiotherapy and Radiochemotherapy on The Quality of Life of 1-year Survivors with Cervical Cancer, Cancer Manag Res. 2011; DOI: 10.2147/CMR.S20255. 3:247-251.
  4. Komite Nasional Penanganan Kanker (KPKN). Panduan Pelayanan Klinis Kanker Serviks, Jakarta: Kementerian Kesehatan Republik Indonesia; 2015.
  5. National Comprehensive Cancer Network (NCCN) 2013. NCCN Clinical Practice Guidelines in Oncology Cervical Cancer version 2.2013.1-2. www.nccn.org. Dipublikasikan 2013. Diakses 25 November 2015.
  6. Tunas, I.K., Yowani, S.C., Indrayathi, P.A., Noviani, R., Budiana, I.N.G., 2016, Penilaian Kualitas Hidup Pasien kanker Serviks dengan Kemoterapi Paklitaksel-Carboplatin di RSU Sanglah, ICJP, 2016; 5(1):35-46
  7. Noviyani, R., Budiana, I.G.D., Indrayathi, P.A., Assessment of Life Quality of Cervical Cancer Patients Delivered Bleomycin-Oncovin-Mitocyn-Platinum (BOMP) Chemotherapy Regimens in Sanglah Denpasar, IJBB, 2015; DOI: https://doi.org/10.15416/ijcp.2015.4.2.106. 2(2):54-62.
  8. Perwitasari, D.A., Pengukuran Kualitas Hidup Pasien Kanker Sebelum dan Sesudah Kemoterapi dengan EORTC QLQ C-30 di RSUP Dr. Sardjito Yogyakarta, Indonesian J Pharm, 2009; ISSN: 0126-1037; 20(2):68-72.
  9. Glaze, S., Lisa, T., Pamela, C., Prafull, G., Jill, N., Greg, N.. Dose-dense Paclitaxel with Carboplatin for Advanced Ovarian Cancer: a Feasible Treatment Alternative. JOGC,2013; 35(1):61-66
  10. Setiawan, SD., The Effect of Chemotherapy in Cancer Patients to Anxiety, Majority, 2015; ISSN : 2337-3776. 4(4):94-99.
  11. Schagen, S.B., dan Wefel, J.S., Chemotherapy-related Changes in Cognitive Functioning, EJC Supplements II, 2013;11(2): 225-232.
  12. Lammers, Y., O’ Rourke, B., Gilbert, R.L., Keeling C., Matthews, D.E., Stacpoole, P.W. and Gregory III, J.F., Vitamin B-6 Restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women, Am J Clin Nutr. 2009; 90:336-43.
  13. Singh, H., Kaur, K., Banipal, R.P.S., Singh, S., Bala, R., 2014, Quality of Life in Cancer Patients Undergoing Chemotherapy in a Tertiary Care Center in Malwa Region of Punjab, Indian J Palliat Care. 2014; DOI: 10.4103/0973-1075.105683. 20(2):116-122.
  14. Hawkins, R., Grunberg, S., Chemotherapy Induced Nausea and Vomiting: Challenges and Opportunities for Improved Patients Outcomes, CJON; e-ISSN: 1538-067X. 2009; 13(1):54-64.
  15. Tonato, M. (Ed.), Antiemetics in The Supportive Care of Cancer Patients, Springer, Perugia; 2012
  16. Park, H.J., Chemotherapy Induced Peripheral Neurophatic Pain, Korean J Anesthesiol. 2014; e-ISSN: 2005-7563. 67(1):4-7
  17. Astolfi, L., Ghiselli, S., Guaran, V., Chicca, M., Simoni, E., Olivetto, E., Lelli, G. and Martini, E., Correlation of Adverse Effects of Cisplatin Administration in Patients Affected by Solid Tumours : A Retrospective Evaluation, Oncol Rep. 2013; 29:1285-1292
  18. Nugroho, A.E., Farmakologi Obat-obat Penting dalam Pembelajaran Ilmu Farmasi dan Dunia Kesehatan, Pustaka Pelajar, Yogyakarta; 2013
  19. Otte, J.L., Carpenter, J.S., Manchanda, S., Rand, K.L., Skaar, T.C., Weaver, M., Chernyak, Y., Zhong, X., Igega, C. And Landis, S., Systematic Review of Sleep Disorder in Cancer Patients : Can The Prevalence of Sleep Disorders be Ascertained?, Cancer Med; e-ISSN: 2015. 4(2): 183-200
  20. McQuade, R.M., Stojanovska, V., Abalo, R., Bornstein, J.C. and Nurgali, K., Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments, Front Pharmacol. 2016; e-ISSN: 1663-9812. 7:1-9.
  21. Stein, A., Voigt, W. and Jordan, K., Chemotherapy-Induced Diarrhea: Pathophysiology, Frequency and Guideline-Based Management, Ther Adv Med Oncol. 2010; e-ISSN: 1758-8359. 2(1):51-63.
  22. Greimel, E., Thiel, I., Peintinger, F., Cegnar, I., Pongratz, E, Prospective Assessment of Quality of Life of Female Cancer Patients, www.gynecologiconcology-online.net. Dipublikasikan 2014. Diakses 1 Desember 2016.

DOI: https://doi.org/10.22146/jmpf.44475

Article Metrics

Abstract views : 2125 | views : 2175


  • There are currently no refbacks.

Copyright (c) 2020 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Jurnal Manajemen dan Pelayanan Farmasi
Faculty of Pharmacy
Universitas Gadjah Mada
Creative Commons License
View My Stats