Apakah Endometriosis Mempengaruhi Kualitas Embryo pada Pasien Invitro Fertilization?

https://doi.org/10.22146/jkr.63039

Dewanto Suryoningrat(1*), Abdurahman Laqif(2), Soetrisno Soetrisno(3), Uki Retno Budihastuti(4), Sri Sulistyowati(5)

(1) Sebelas Maret University
(2) Sebelas Maret University
(3) Sebelas Maret University
(4) Sebelas Maret University
(5) Sebelas Maret University
(*) Corresponding Author

Abstract


Latar Belakang Invitro Fertilization merupakan salah satu manajemen infertilitas yang baik, namun masih didapatkan adanya kesamaan peluang kegagalan perkembangan embrio sebanyak 50% dibandingkan dengan pasien yang tidak mengalami endometriosis.

Tujuan: untuk mengetahui hubungan endometriosis dan kualitas embrio pada pasien yang menjalani program invitro fertilization.

Metode: Data yang dikumpulkan merupakan data pada rekam medis pasien Klinik Fertilitas Sekar yang menjalani invitro fertilization di Klinik Fertilitas Sekar RSUD Dr. Moewardi Surakarta pada Januari 2010 – Desember 2019. Analisis menggunakan uji deskriptif dan Uji T tidak berpasangan. Hasil dianggap signifikan jika p ≤ 0,05.

Hasil dan Pembahasan: Dalam penelitian ini, rerata kualitas embrio baik memiliki perbedaan yang signifikan (p<0.05) antara pasien dengan endometriosis dan pasien tanpa endometriosi, sedangkan kualitas embrio buruk tidak memiliki perbedaan yang signifikan (p>0.05).

Kesimpulan: Endometriosis memiliki hubungan yang signifikan dengan kualitas embrio pada wanita yang menjalani program IVF.


Keywords


endometriosis; invitro fertilization; kualitas embrio

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References

  1. Evans, M. B. and Decherney, A. H. ‘Fertility and Endometriosis’, Clinical Obstetrics and Gynecology 2017 ,60(3), pp. 497–502.
  2. Jamaan T., Boediono A., Pakasi T A., Moeloek F A., ‘Improving the probability of pregnancy in endometriosis cases: A study in patients undergoing in vitro fertilization’, Medical Journal of Indonesia 2012, 21(3), pp. 147–151
  3. Da Broi, M. G. and Navarro, P. A. ‘Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility’, Cell and Tissue Research 2016, 364(1).
  4. Singh, N., Lata, K., Naha, M., Malhotra, N., Tiwari, A., Vanamail, P. ‘Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles’, Journal of Human Reproductive Sciences 2014, 7(2), pp. 143–147.
  5. Sanchez, Ana M., Pagliardini, L., Cermisoni, Greta C., Privitera, L., Makieva, S., Alteri, A., et al. ‘Does endometriosis influence the embryo quality and/or development? Insights from a large retrospective matched cohort study’, Diagnostics 2020, 10(2).
  6. Cohen, J., Ziyyat, A., Naoura, I., Chabbert-Buffet, N., Aractingi, S., Darai, E., & Lefevre, B. Effect of induced peritoneal endometriosis on oocyte and embryo quality in a mouse model. Journal of Assisted Reproduction and Genetics 2014, 32(2), 263–270.
  7. Gardner, D. K. and Balaban, B. ‘Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and “OMICS”: Is looking good still important?’, Molecular Human Reproduction 2016, 22(10), pp. 704–718.
  8. Borges, E., Braga, D. P., Setti, A. S., Figueira, R. C., Pasqualotto, F. F., & Iaconelli, A ‘The influence of endometriosis on oocyte quality and embryo developmental competence’, Fertility and Sterility 2015, 104(3), pp. e201–e202.
  9. Pellicer A, Albert C, Garrido N, Navarro J, Remohí J, Simón C. The pathophysiology of endometriosis-associated infertility: follicular environment and embryo quality. Journal of Reproduction and fertility. Supplement. 2000 ;55:109-119.
  10. Chapron, C. Marcellin L., Borghese B., Santulli P ‘Rethinking mechanisms, diagnosis and management of endometriosis’, Nature Reviews Endocrinology 2019. Springer US, 15(11), pp. 666–682.
  11. Donnez J, Donnez O, Orellana R, Binda MM, Dolmans MM. Endometriosis and infertility. Panminerva Med. 2016;58(2):143-150.
  12. Sanchez, A M., Vanni, V S., Bartiromo, L., Papaleo, E., Zilberberg, E., Candiani, M., et al. ‘Is the oocyte quality affected by endometriosis? A review of the literature’, Journal of Ovarian Research 2017. Journal of Ovarian Research, 10(1), pp. 1–11.
  13. Xu, B., Guo, N., Zhang, X., Shi, W., Tong, X., Iqbal, F., & Liu, Y. ‘Oocyte quality is decreased in women with minimal or mild endometriosis’, Scientific Reports 2015, 5, pp. 1–8.
  14. Al-Fadhli, R., Kelly, S. M., Tulandi, T., & Lin Tan, S ‘Effects of Different Stages of Endometriosis on the Outcome of In Vitro Fertilization’, Journal of Obstetrics and Gynaecology Canada. Elsevier Masson SAS 2006, 28(10), pp. 888–891



DOI: https://doi.org/10.22146/jkr.63039

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