Hubungan Kadar Interferon Gamma (IFN-γ) Pada Cairan Asites Dan Darah Dengan Grade Karsinoma Ovarium

https://doi.org/10.22146/jkr.44181

Sakina Nasir Bagis(1*), Moh Nailul Fahmi(2), Hanggoro Tri Rinonce(3)

(1) Universitas Gadjah Mada
(2) Departemen Obstetri dan Ginekologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, UGM
(3) Departemen Patologi Anatomi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, UGM
(*) Corresponding Author

Abstract


Latar Belakang: Kanker ovarium dapat digolongkan berdasarkan grade, yang dibagi menjadi low grade dan high grade. IFN-γ memiliki efek anti-tumor dan juga pro-tumor. Penelitian tentang kadar IFN-γ pada asites dan darah serta hubungannya dengan grade belum banyak dilakukan.

Tujuan: Mengetahui hubungan kadar interferon gamma (IFN-γ) dengan grade karsinoma ovarium pada cairan asites dan darah.

Metode: Penelitian cross sectional dengan sampel asites dan darah dari pasien karsinoma ovarium yang dilakukan operasi di RSUP Dr. Sardjito.

Hasil dan Pembahasan: Pada sampel asites rata-rata pada low grade sebesar 0,57 pg/ml, pada high grade sebesar 0,68 pg/ml, pada sampel darah rata-rata pada low grade sebesar 0,74 pg/ml, pada high grade sebesar 0,84 pg/ml. Namun perbedaan rata-rata tersebut tidak signifikan (asites, p=0,780; darah, p=0,861). Pada cairan asites dan darah, rata-rata pada asites sebesar 0,66 pg/ml, pada darah 0,81 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan (p=0,568).

Kesimpulan: Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) cairan asites dan darah pada karsinoma ovarium low grade dan high grade. Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) pada cairan asites dan darah karsinoma ovarium.

 

Kata Kunci: asites, darah, grade, interferon gamma (IFN-γ), karsinoma ovarium

Keywords


asites; darah; grade; interferon gamma (IFN-γ); karsinoma ovarium; kanker ovarium

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DOI: https://doi.org/10.22146/jkr.44181

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