Hubungan Kadar Interferon Gamma (IFN-γ) Pada Cairan Asites Dan Darah Dengan Grade Karsinoma Ovarium

https://doi.org/10.22146/jkr.44181

Sakina Nasir Bagis(1*), Moh Nailul Fahmi(2), Hanggoro Tri Rinonce(3)

(1) Universitas Gadjah Mada
(2) Departemen Obstetri dan Ginekologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, UGM
(3) Departemen Patologi Anatomi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, UGM
(*) Corresponding Author

Abstract


Latar Belakang: Kanker ovarium dapat digolongkan berdasarkan grade, yang dibagi menjadi low grade dan high grade. IFN-γ memiliki efek anti-tumor dan juga pro-tumor. Penelitian tentang kadar IFN-γ pada asites dan darah serta hubungannya dengan grade belum banyak dilakukan.

Tujuan: Mengetahui hubungan kadar interferon gamma (IFN-γ) dengan grade karsinoma ovarium pada cairan asites dan darah.

Metode: Penelitian cross sectional dengan sampel asites dan darah dari pasien karsinoma ovarium yang dilakukan operasi di RSUP Dr. Sardjito.

Hasil dan Pembahasan: Pada sampel asites rata-rata pada low grade sebesar 0,57 pg/ml, pada high grade sebesar 0,68 pg/ml, pada sampel darah rata-rata pada low grade sebesar 0,74 pg/ml, pada high grade sebesar 0,84 pg/ml. Namun perbedaan rata-rata tersebut tidak signifikan (asites, p=0,780; darah, p=0,861). Pada cairan asites dan darah, rata-rata pada asites sebesar 0,66 pg/ml, pada darah 0,81 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan (p=0,568).

Kesimpulan: Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) cairan asites dan darah pada karsinoma ovarium low grade dan high grade. Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) pada cairan asites dan darah karsinoma ovarium.

 

Kata Kunci: asites, darah, grade, interferon gamma (IFN-γ), karsinoma ovarium

Keywords


asites; darah; grade; interferon gamma (IFN-γ); karsinoma ovarium; kanker ovarium

Full Text:

PDF


References

  1. American Cancer Society. 2018. Ovarian Cancer. Atlanta: American Cancer Society, Inc. 2018. Didapat dari https://www.cancer.org/cancer/ovarian-cancer/about/key-statistics.html diakses 20 Mei 2018
  2. World Health Organization. 2014. Cancer Country Profile: Indonesia. Didapat dari https://www.who.int/cancer/country-profiles/idn_en.pdf diakses 28 Desember 2018
  3. World Health Organization. 2014. WHO Classification of Tumors of Female Reproductive Organs. 4th Edition. pp 15-40.
  4. Cancer Research UK. 2017. Cancer Grading. Didapat dari https://www.cancerresearchuk.org/about-cancer/what-is-cancer/cancer-grading diakses 20 Mei 2018.
  5. Chen, Y.L., Cheng, W.F., Chang, M.C., Lin, H.W., Huang, C.T., Chien, C.L. and Chen, C.A., 2013. Interferon-gamma in ascites could be a predictive biomarker of outcome in ovarian carcinoma. Gynecologic oncology, 131(1), pp.63-68.
  6. Mojic, M., Takeda, K. and Hayakawa, Y., 2017. The dark side of IFN-γ: its role in promoting cancer immunoevasion. International journal of molecular sciences, 19(1), p.89.
  7. Zaidi, M.R. dan Merlino, G., 2011. The two faces of interferon-γ in cancer. Clinical cancer research, 17(19), pp.6118-6124.
  8. Castro, F., Cardoso, A.P., Gonçalves, R.M., Serre, K. and Oliveira, M.J., 2018. Interferon-gamma at the crossroads of tumor immune surveillance or evasion. Frontiers in immunology, 9, p.847.
  9. Duncan, T.J., Rolland, P., Deen, S., Scott, I.V., Liu, D.T., Spendlove, I. and Durrant, L.G., 2007. Loss of IFNγ receptor is an independent prognostic factor in ovarian cancer. Clinical cancer research, 13(14), pp.4139-4145.
  10. 10. Cândido, E.B., Silva, L.M., Carvalho, A.T., Lamaita, R.M., Filho, R.M.P., Cota, B.D.C.V. and Silva-Filho, A.L.D., 2013. Immune response evaluation through determination of type 1, type 2, and type 17 patterns in patients with epithelial ovarian cancer. Reproductive Sciences, 20(7), pp.828-837.
  11. 11. Nowak, M., Glowacka, E., Szpakowski, M., Szyllo, K., Malinowski, A., Kulig, A., Tchorzewski, H. and Wilczynski, J., 2010. Proinflammatory and immunosuppressive serum, ascites and cyst fluid cytokines in patients with early and advanced ovarian cancer and benign ovarian tumors. Neuroendocrinology Letters, 31(3), pp.375-383.
  12. 12. Bamias, A., Koutsoukou, V., Terpos, E., Tsiatas, M.L., Liakos, C., Tsitsilonis, O., Rodolakis, A., Voulgaris, Z., Vlahos, G., Papageorgiou, T. and Papatheodoridis, G., 2008. Correlation of NK T-like CD3+ CD56+ cells and CD4+ CD25+ (hi) regulatory T cells with VEGF and TNFα in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy. Gynecologic oncology, 108(2), pp.421-427.



DOI: https://doi.org/10.22146/jkr.44181

Article Metrics

Abstract views : 3567 | views : 2796

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Kesehatan Reproduksi Indexed by:

 

 



SEKRETARIAT JURNAL KESEHATAN REPRODUKSI
Departemen Obstetri dan Ginekologi, FK-KMK, UGM/RS Dr. Sardjito
Jl. Kesehatan No. 1, Sekip Utara, Yogyakarta 55281
Tlp: (0274) 511329 / Faks: (0274) 544003
Email: jurnal.kesehatanreproduksi@ugm.ac.id
Cp: Dwi Astuti +6281802698043