Kadar 25(OH)D3 darah pada penderita obesitas


Dessy Hermawan(1*), Slamet Widodo(2)

(1) Program Studi Ilmu Keperawatan, Fakultas Kedokteran Universitas Malahayati Bandar Lampung
(2) Program Kedokteran, Fakultas Kedokteran Universitas Malahayati Bandar Lampung
(*) Corresponding Author


Blood level 25(OH)D3 in obese people

Background: Currently, obesity is a world problem, even the World Health Organization (WHO) declared obesity to be a global epidemic and contributes 5% of global deaths in 2015. Recently, many studies have reported an association between vitamin D levels and the incidence of obesity, although the exact mechanism raises many questions.  

Objective: This study is to examine the correlation between levels of 25(OH)D3 and body mass index (BMI).

Methods: The design of this research is an analytic survey with a case control approach. The population of this study was all students of the Faculty of Medicine, Malahayati University, Bandar Lampung. The number of samples in this study were 60 samples with details of 30 case samples (obesity) and 30 control samples (no obesity). The sampling technique used was purposive sampling. The data used are primary data from direct measurement results. The data were analyzed using the correlation test.

Results: The results showed that only one sample had normal 25(OH)D3 levels, while most (more than 98%) had low and very low levels of 25(OH)D3. The correlation test showed that there was a significant relationship between 25(OH)D3 levels with BMI (p=0.008; r= -0.0338), gender (p=0.001; r= -0.457), and total cholesterol levels (p=0.009); r= -0,391).

Conclusions: There is a relationship between levels of 25(OH)D3 with BMI, the lower the 25(OH)3 blood level, the higher the risk of increasing BMI. Further research is still needed to ensure that giving vitamin D to obese populations can reduce body weight or BMI.


body mass index (BMI); obesity; total cholesterol; vitamin D

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  1. Wardani DAK, Huriyati E, Mustikaningtyas, Hastuti J. Obesitas, body image, dan perasaan stres pada mahasiswa di Daerah Istimewa Yogyakarta. Jurnal Gizi Klinik Indonesia. 2015;11(4):161-9. doi: 10.22146/ijcn.22649
  2. Hermawan D, Muhani N, Sari N, Arisandi S, Widodo S, Firdaus AA, et al. Mengenal obesitas. Yogyakarta: Penerbit Buku Andi; 2020
  3. World Health Organization. Obesity. [series online] 2020 [cited 26 Jan 2021]. Available from: URL: https://www.who.int/news-room/facts-in-pictures/detail/6-facts-on-obesity
  4. Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia. Hasil utama Riskesdas tahun 2018. [series online] 2018 [cited 26 Jan 2021]. Available from: URL: https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf
  5. Kanter R, Caballero B. Global gender disparities in obesity: a review. Adv Nutr. 2012;3(4):491-8. doi: 10.3945/an.112.002063
  6. Teachman J. Body weight, marital status, and changes in marital status. J Fam Issues. 2016;37(1):74-96. doi: 10.1177/0192513X13508404
  7. Conklin AI, Ponce NA, Frank J, Nandi A, Heymann J. Minimum wage and overweight and obesity in adult women: a multilevel analysis of low and middle income countries. PLoS One. 2016;11(3):e0150736. doi: 10.1371/journal.pone.0150736
  8. Srivastava A, Srivastava N, Mittal. B. Genetics of obesity. Indian J Clin Biochem. 2016;31(4):361-71. doi: 10.1007/s12291-015-0541-x
  9. Silveira EAD, Vieira LL, Jardim TV, Souza JDD. Obesity and its association with food consumption, diabetes mellitus, and acute myocardial infarction in the elderly. Arq Bras Cardiol. 2016;107(6):509-17. doi: 10.5935/abc.20160182
  10. Pratiwi AA, Nindya TS. Hubungan konsumsi camilan dan durasi waktu tidur dengan obesitas di permukiman padat Kelurahan Simolawang, Surabaya. Amerta Nutrition. 2017;1(3):153-61. doi: 10.20473/amnt.v1i3.2017.153-161
  11. Kim BY, Choi DH, Jung CH, Kang SK, Mok JO, Kim CH. Obesity and physical activity. J Obes Metab Syndr. 2017;26(1):15-22. doi: 10.7570/jomes.2017.26.1.15
  12. Vanlint S. Vitamin D and obesity. Nutrients. 2013;5(3):949-56. doi: 10.3390/nu5030949
  13. Soskić S, Stokić E, Isenović ER. The relationship between vitamin D and obesity. Current Medical Research and Opinion. 2014;30(6):1197-9. doi: 10.1185/03007995.2014.900004
  14. Hermawan D. Sehat selalu dengan vitamin D. Yogyakarta: Penerbit Buku Andi; 2016.
  15. Soares MJ, Chan She Ping-Delfos W, Ghanbari MH. Calcium and vitamin D for obesity: a review of randomized controlled trials. Eur J Clin Nutr. 2011;65(9):994-1004. doi: 10.1038/ejcn.2011.106
  16. Hall JE. Guyton and hall review physiology 13th edition. Philadelphia: Sauders-Elsevier; 2015.
  17. Sherwood LZ. Human physiology form cell to systems 9th edition. USA: Cangage Learning; 2016.
  18. Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil PA. Harper’s illustrated biochemistry 28th edition. New York: Mc Graw Hill Lange; 2009.
  19. Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Yanovski JA, et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004;89(3):1196-9. doi: 10.1210/jc.2003-031398
  20. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6S. doi: 10.1093/ajcn/87.4.1080S
  21. Lhamo Y,Chugh PK,Gautam SR, Tripathi CD. Epidemic of vitamin D deficiency and its management: awareness among Indian medical undergraduates. J Environ Public Health. 2017;2017:2517207. doi: 10.1155/2017/2517207
  22. Hermawan D, Andoko. Hubungan antara kadar vitamin D dalam darah dengan tekanan darah usia lanjut di Natar Lampung Selatan. Jurnal Keperawatan Sriwijaya. 2019;6(1):1-8.
  23. Haimi M, Kremer R. Vitamin D deficiency/insufficiency from childhood to adulthood: insights from a sunny country. World J Clin Pediatr. 2017;6(1):1-9. doi: 10.5409/wjcp.v6.i1.1
  24. Santos MP, Costa PRF, Assis AMO, Santis CAST, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16(4):341-9. doi: 10.1111/obr.12239
  25. Salehpour A, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Gohani M, et al. A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women. Nutr J. 2012;11:78. doi: 10.1186/1475-2891-11-78
  26. Verdoia M, Schaffer A, Barbieri L, Giovine DG, Marino P, Luca GD, et al. Impact of gender difference on vitamin D status and its relationship with the extent of coronary artery disease. Nutr Metab Cardiovasc Dis. 2015;25(5):464-70. doi: 10.1016/j.numecd.2015.01.009
  27. Shahudin NN, Sameeha MJ, Ludin AFM, Manaf ZA, Chin KY, Jamil NA. Barriers towards sun exposure and strategies to overcome these barriers in female indoor workers with insufficient vitamin D: a qualitative approach. Nutrients. 2020;12(10):2994. doi: 10.3390/nu12102994
  28. Brot C, Vestergaard P, Kolthoff N, Gram J, Hermann AP, Sorensen H. Vitamin D status and its adequacy in healthy Denish perimenopausal women: relationship to diatary intake, sux exposure and serum parathyroid hormone. Br J Nutr. 2001; 86(Suppl 1):S97-103. doi: 10.1079/bjn2001345
  29. Johnson LK, Hofsø1 D, Aasheim ET, Tanbo T, Holven KB, Hjelmesæth J, et al. Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study. Eur J Clin Nutr. 2012;66(1):83-90. doi: 10.1038/ejcn.2011.140
  30. Dibaba DT. Effect of vitamin D supplementation on serum lipid profiles: a systematic review and mata-analysis. Nutr Rev. 2019;77(12):890-902. doi: 10.1093/nutrit/nuz037
  31. Ohlund I, Lind T, Hernell O, Silfverdal SA, Liv P, Akeson PK. Vitamin D status and cardiometabolic risk marker in young Swedish children: a double-blind randomized clinical trial comparing different doses of vitamin D supplements. Am J Clin Nutr. 2020;111(4):779-86. doi: 10.1093/ajcn/nqaa031
  32. Wortsman J, Matsuoka LY, Chen TC, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690-3. doi: 10.1093/ajcn/72.3.690

DOI: https://doi.org/10.22146/ijcn.59751

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