The effect of lesser yam based cookies on fasting glucagon-like peptide 1, appetite, and dietary intake in overweight/obese with ad libitum diet

https://doi.org/10.22146/ijcn.51762

Harry Freitag Luglio Muhammad(1*), Annisa Lailatul Fitria(2), Dewi Ayu Kusumawardhani(3), Rinta Amalia(4), Desy Dwi Hapsari(5), Rina Susilowati(6), Sunarti Sunarti(7)

(1) Department of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(2) Department of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(3) Department of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(4) Department of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(5) Department of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(6) Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(7) Department of Biochemistry, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Background: Appetite and dietary intake have been associated with obesity and successfulness of weight loss in obese individuals. Glucagon-like peptide 1 is a gut-derived neuropeptide that is produced as a response to dietary intake and associated with appetite. It has been investigated that prebiotic can induce GLP-1 production in animal models and humans. 

Objectives: This study aimed to investigate the effect of lesser yam based cookies on fasting GLP-1 plasma, appetite, and dietary intake.

Methods: An experimental study was conducted on 15 overweight/obese individuals using cookies made with lesser yam flour for 6 weeks. Fasting GLP-1 level, dietary intake, and appetite were measured before and after the intervention. Dietary intake was recorded using a semi-quantitative food frequency questionnaire and appetite was measured using a visual analog scale.

Results: After the intervention, the dietary intake includes total energy (p=0,013), protein (p=0,004) and carbohydrate (p=0,02) were significantly reduced. Based on paired t-test that was done in each time point, after the intervention subjects had lower hunger feeling and higher satiety especially at 4 (p=0,039) and 3 (p=0,039) hours after breakfast, respectively. Fasting GLP-1 plasma level was not changed after the intervention (p>0,05). There is no correlation between GLP-1 and dietary intake as well as appetite. 

Conclusions: We concluded that lesser yam based cookies were able to reduce dietary intake and hunger as well as increase fullness. The fasting GLP-1 concentration did not change after the intervention this was not associated with changes in satiety, fullness, desire to eat, or energy intake.


Keywords


appetite; GLP-1; intake; overweight; prebiotics

Full Text:

PDF


References

  1. GBD 2015 Obesity Collaborators, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13-27. doi: 10.1056/nejmoa1614362
  2. Weiss EC, Galuska DA, Kettel Khan L, Gillespie C, Serdula MK. Weight regain in U.S. adults who experienced substantial weight loss, 1999-2002. Am J Prev Med. 2007;33(1):34-40. doi: 10.1016/j.amepre.2007.02.040
  3. Turk MW, Yang K, Hravnak M, Sereika SM, Ewing LJ, Burke LE. Randomized clinical trials of weight-loss maintenance: a review. J Cardiovasc Nurs. 2009;24(1):58-80. doi: 10.1097/01.JCN.0000317471.58048.32
  4. Kraschnewski JL, Boan J, Esposito J, Sherwood NE, Lehman EB, Kephart DK, et al. Long-term weight loss maintenance in the United States. Int J Obes (Lond). 2010;34(11):1644-54. doi: 10.1038/ijo.2010.94
  5. Weigle DS, Sande KJ, Iverius PH, Monsen ER, Brunzell JD. Weight loss leads to a marked decrease in nonresting energy expenditure in ambulatory human subjects. Metabolism. 1988;37(10):930-6. doi: 10.1016/0026-0495(88)90149-7
  6. Doucet E, Imbeault P, St-Pierre S, Alméras N, Mauriège P, Després JP, et al. Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. Clin Sci (Lond). 2003;105(1):89-95. doi: 10.1042/CS20020252
  7. Mariman ECM. Human biology of weight maintenance after weight loss. J Nutrigenet Nutrigenomics. 2012;5(1):13-25. doi: 10.1159/000337081
  8. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, et al. Long-term persistence of hormonal adaptations to weight loss. N Eng J Med. 2011;365(17):1597-604. doi: 10.1056/NEJMoa1105816
  9. Van Bloemendaal L, ten Kulve JS, La Fleur SE, Ijzerman RG, Diamant M. Effects of glucagon-like peptide 1 on appetite and body weight: Focus on the CNS. J Endocrinol. 2014;221(1). doi: 10.1530/JOE-13-0414
  10. Näslund E, Gutniak M, Skogar S, Rössner S, Hellström PM. Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men. Am J Clin Nutr. 1998;68(3):525-30. doi: 10.1093/ajcn/68.3.525
  11. Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest. 1998;101(3):515-20. doi: 10.1172/JCI990
  12. Gutzwiller JP, Drewe J, Göke B, Schmidt H, Rohrer B, Lareida J, et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol. 1999;276(5):R1541-4. doi: 10.1152/ajpregu.1999.276.5.R1541
  13. Cani PD, Dewever C, Delzenne NM. Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr. 2004;92(3):521-6. doi: 10.1079/bjn20041225
  14. Cani PD, Lecourt E, Dewulf EM, Sohet FM, Pachikian BD, Naslain D, et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr. 2009; 90(5):1236-43. doi: 10.3945/ajcn.2009.28095
  15. Luglio HF, Fitria AL, Kusumawardhani DA, Amalia R, Hapsari DD, Susilowati R, et al. Lesser yam (Dioscorea esculenta) based cookies improves lipid profile in overweight/obese adults with an ad libitum diet via glucagon like peptide 1. Nutrition and Food Science. 2016;46(3):336-43. doi: 10.1108/NFS-10-2015-0131
  16. Wilujeng KG. Pembuatan inulin bubuk dari umbi gembili (Dioscorea esculenta) dengan metode foam mat drying [Thesis]. Surabaya: Universitas Pembangunan Nasional Veteran; 2010.
  17. Liber A, Szajewska H. Effects of inulin-type fructans on appetite, energy intake, and body weight in children and adults: systematic review of randomized controlled trials. Ann Nutr Metab. 2013;63(1-2):42-54. doi: 10.1159/000350312
  18. Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr. 2009;89(6):1751-9. doi: 10.3945/ajcn.2009.27465
  19. Harrold JA, Hughes GM, O’Shiel K, Quinn E, Boyland EJ, Williams NJ, et al. Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice. Appetite. 2013;62:84-90. doi: 10.1016/j.appet.2012.11.018
  20. Verhoef SPM, Meyer D, Westerterp KR. Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake. Br J Nutr. 2011;106(11):1757-62. doi: 10.1017/S0007114511002194
  21. Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, et al. Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals. Clin Nutr. 2004;23(3):331-40. doi: 10.1016/j.clnu.2003.07.010
  22. Hess JR, Birkett AM, Thomas W, Slavin JL. Effects of short-chain fructooligosaccharides on satiety responses in healthy men and women. Appetite. 2011;56(1):128-34. doi: 10.1016/j.appet.2010.12.005
  23. Karalus M, Clark M, Greaves KA, Thomas W, Vickers Z, Kuyama M, et al. Fermentable fibers do not affect satiety or food intake by women who do not practice restrained eating. J Acad Nutr Diet. 2012;112(9):1356-62. doi: 10.1016/j.jand.2012.05.022



DOI: https://doi.org/10.22146/ijcn.51762

Article Metrics

Abstract views : 1925 | views : 2062

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2019 Jurnal Gizi Klinik Indonesia

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Gizi Klinik Indonesia (JGKI) Indexed by:
 
  

  free web stats View My Stats