Faktor risiko dan asupan isoflavon pada pasien kanker payudara

I Wayan Dwija Karyasa; Johan Kurnianda; Herni Astuti

doi:10.22146/ijcn.18876

Faktor risiko dan asupan isoflavon pada pasien kanker payudara

https://doi.org/10.22146/ijcn.18876

I Wayan Dwija Karyasa^(1*), Johan Kurnianda⁽²⁾, Herni Astuti⁽³⁾

(1) Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya,
(2) Instalasi Kanker Terpadu Rumah Sakit Umum Pusat Dr.Sardjito, Yogyakarta
(3) Instalasi Gizi Rumah Sakit Umum Pusat Dr. Sardjito, Yogyakarta
(*) Corresponding Author

Abstract

Background: Breast cancer is noncommunicable chronic disease the prevalence of which is increasing all over the world, including in Indonesia and particularly East Java. Causes of breast cancer are unknown. Some studies show risk factors for breast cancer are hormonal, genetic, reproductive and endocrinologic factors. There is the isoflavon compound in soybeans that is known as anti-cancer with anti-estrogen activities.

Objective: The study was aimed at identifying risk factor and the difference of isoflavone intake between breast cancer patients and healthy people in hospitals.

Method: The study was analytic observational using matched case-control study design at comparison 1:2 with matching on a status of menopause. Cases were positive receptor estrogen breast cancer patients newly diagnosed during the first visit at hospital outpatient Oncologic Surgery Polyclinic. Controls were staff considered healthy based on the result of health examination at Dr. Ramelan Naval Hospital of Surabaya. Cases comprised 49 people and control 98 people taken through consecutive method. Data consisted of an identity of samples, weight, height, isoflavone intake, family history, use of hormone replacement therapy and parity. Intake of isoflavones was obtained from semiquantitative food frequency questionnaire (SQ-FFQ) and statistical test used Chi-Square and Odd Ratio (OR).

Results: There was the difference in isoflavone intake and family history between cases and controls (p<0.05) and there was an association between isoflavone intake (OR=2.58; p=0.007) and family history (OR=18; p=0.002) and the incidence of breast cancer. There was no association between the status of obesity, parity, and use of hormone replacement therapy.

Conclusion: There are differences in isoflavone intake of breast cancer patients compared with healthy people and there was no difference in the status of obese breast cancer patients compared to healthy individuals and isoflavone intake less 2.85 times the risk of breast cancer compared with adequate intake of isoflavones.

Keywords

risk factors; isoflavon intake; breast cancer

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References

Pamungkas Z. Deteksi dini kanker payudara. Yogyakarta: Buku Biru; 2011.

Dinas Kesehatan Provinsi Jawa Timur. Kegiatan pengendalian kanker di Jawa Timur. [series online] 2012 [cited 2012 Oktober 20]. Available from: URL: http://www.dinkesjatimprov.go.id/contendetail/11/3/156/kegiatan-pengendalian-kanker-di-jawa-timr.html

Yayasan Kanker Indonesia. YKI – Jakarta Race. [series online] 2012 [cited 2012 Oktober 20]. Available from: URL: http://www.yayasankankerindonesia.org/2012/yki-jakarta-race/

Rumkital Dr Ramelan. Laporan triwulan I rawat jalan Rumkital Dr. Ramelan 2012. Surabaya: Rumkital Dr Ramelan; 2012.

Rasjidi I. Deteksi dini dan pencegahan kanker pada wanita. Jakarta: CV Sagung Seto; 2009.

Corwin EJ. Patofisiologi. Nike Budhi Subekti (Alih bahasa). Jakarta: Penerbit Buku Kedokteran EGC; 2008.

Koswara S. Isoflavon, zat multi manfaat dalam kedelai. [series online] 2006 [cited 2012 Maret 5]. Available from: URL: http://www.ebook.pangan.com/artikel/Pdf

Sastroasmoro S, Ismael S. Dasar – dasar metodologi penelitian klinis edisi ke-4. Jakarta: Sagung Seto; 2011.

Lemeshow S, Hosmer Jr DW, Klar J, Stephen K. Besar sampel dalam penelitian kesehatan. Yogyakarta: Gadjah Mada University Press; 1997.

Gibson RS. Principles of nutritional assessment. New York: Oxford University Press; 1990.

Astawan M. Sehat dengan hidangan kacang dan biji – bijian. Jakarta: Penebar Swadaya; 2009.

Pusat Diabetes dan Lipid RSCM/FKUI. Pengkajian status gizi studi epidemiologi. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2003.

Budiarto E. Biostatistika untuk kedokteran dan kesehatan masyarakat. Jakarta: Penerbit Buku Kedokteran EGC; 2001.

Marchbanks PA, Curtis KM, Mandel MG, Wilson HG, Jeng G, Folger SG, McDonald JA, Daling JR, Bernstein L, Malone KE, Wingo PA, Simon MS, Norman SA, Strom BL, Ursin G, Weiss LK, Burkman RT, Spirtas R. Oral contraceptive formulation and risk of breast cancer. Contraception 2012;85(4):342-50. doi: 10.1016/j.contraception.2011.08.007.

Speroff L. The risk of breast cancer associated with oral contraception and hormone replacement therapy. Portland, Oregon: The Jacobs Institute of Womens Health; 1992.

La Vecchia C, Bosetti C. Diet and cancer risk in Mediterranean countries: open issues. Public Health Nutr 2006;9(8A):1077-82.

Indrati R, Setyawan H, Handojo D. Faktor faktor risiko yang berpengaruh terhadap kejadian kanker payudara wanita [Tesis]. Semarang: Universitas Diponegoro; 2005.

American Cancer Society. Breast cancer fact & figures 2011-2012. Atlanta: American Cancer Society, Inc; 2011.

Pischon T, Nothlings U, Boeing Heiner. Obesity and cancer. Coleraine: Proceedings of the Nutrition Society; 2008. doi: 10.1017/S0029665108006976.

Aro AR, De Koning HJ, Schreck M, Henriksson M, Anttila A, Pukkala E. Psychological risk factors of incidence of breast cancer: a prospective cohort study in Finland. Psychol Med 2005;35(10):1515-21.

Sauven P. Guidelines for the management of women at increased familial risk of breast cancer. Eur J Cancer 2004;40(5):653-65.

Wohlfahrt J, Rank F, Kroman N, Melbye M. A comparison of reproductive risk factors for CIS lesions and invasive breast cancer. Int J Cancer 2004;108(5):750-3.

DOI: https://doi.org/10.22146/ijcn.18876