Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid

Pramudji Hastuti; Nur Anisah; Johan Iswara Siagian; Kautsar Prastudia Eko Binuko; Aidil Adhla

doi:10.22146/ijcn.17772

Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid

https://doi.org/10.22146/ijcn.17772

Pramudji Hastuti^(1*), Nur Anisah⁽²⁾, Johan Iswara Siagian⁽³⁾, Kautsar Prastudia Eko Binuko⁽⁴⁾, Aidil Adhla⁽⁵⁾

(1) Bagian Biokimia Fakultas Kedokteran Universitas Gadjah Mada
(2) Bagian Histologi dan Biologi Sel Fakultas Kedokteran Universitas Gadjah Mada
(3) Fakultas Kedokteran Universitas Gadjah Mada
(4) Fakultas Kedokteran Universitas Gadjah Mada
(5) Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Background: Obesity among adults has risen significantly in the world-cutting across all ages, racial and ethnic groups and gender. The 5-HT _2A receptor is crucially involved in regulation of body weight and the appetite. Disturbances in the distribution and or gene regulation of the postsynaptic 5-HT_2A receptor are implicated in the pathophysiology of conditions such as obesity, coronary heart disease, high blood pressure, diabetes, stroke dan some cancers.

Objective: To test the association between obesity with polymorphism of promoter -1438G→A 5-HT_2A receptors gene, blood pressure, lipid profiles, levels of blood glucose and malondialdehyde (MDA).

Method: This cross-sectional study included thirty six unrelated obese young people (BMI ≥ 30) recruited from populations in Yogyakarta and 36 controls with age matched with BMI ≤ 25. Statistical differences between blood pressure, lipid profiles, glucose and MDA levels were assessed by t-test and genotypes by Chi square test.

Results: There were no significant difference in blood pressure lipid profile, level of glucose and MDA in obese group compared with control (p>0,05). Allele A and G frequency in obese group 25% and 75% respectively, and controls 22.2% and 77.8% respectively, and no significant difference in all two groups, but G allele had higher risk to obese than A allele.

Conclusion: These data indicated G allele was mild risk factor for obesity.

Keywords

obesitas; tekanan darah; profil lipid; reseptor 5-HT2A

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DOI: https://doi.org/10.22146/ijcn.17772