Pengaruh suplementasi zink (Zn) terhadap diare pada penderita umur 6-36 bulan yang dirawat di RSUD Dr. Soedarso Pontianak, Kalimantan Barat
Jurianto Gambir(1*), Madarina Julia(2), Muhammad Jufrrie(3)
(1) Jurusan Gizi Politeknik Kesehatan Pontianak
(2) Bagian Anak RSUP Dr. Sardjito Yogyakarta/Fakultas Kedokteran Universitas Gadjah Mada
(3) Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Background: Diarrhoea is one of the major causes of infants and childhood death in Indonesia. Malnutrition and zinc deficiency in diarrhoea may lead to impaired immunity.
Objective: To assess the influence of zinc supplementation on the duration of diarrhoea and the frequency of watery stools in under-three-year-old children
Method: This was a double-blind randomized controlled clinical trial, with 31 children in the supplemented group and 33 children in the placebo group. All children had acute watery diarrhea and were given supplementation within 24 hours of admission. Daily supplementation of 20 mg zinc was given to the experimental group.
Results: The supplemented group had a shorter hospitalization compared to the placebo. Beginning from the second day of supplementation, the frequency of watery stools in the supplemented group was significantly less than in the placebo group (p<0.001). While there was a significant decrease in the concentration of zinc in the serum of the placebo group, there was a slight increase in the supplemented group.
Conclusion: Zinc supplementation can shorten hospitalization and reduce the frequency of watery stools in children with diarrhoea.
Keywords
Full Text:
PDFReferences
Departemen Kesehatan. Profil Kesehatan Indonesia. Jakarta; 1997.
Lanata CF, and Black RE. Diarrheal Diseases. In: Richard Semba & Martin W Bloem, editors. Nutrition and Health in Developing Countries New Jersey: Human Press; 2000. p. 93–7.
Wapnir RA. Zinc Deficiency, Malnutrition and Gastrointestinal Tract. J Nutr 2000;130:1388–92.
Hidayat, Achadi, Sunoto, Soedarmo. Pengaruh Pemberian Seng terhadap Diare Memanjang pada Anak Balita. Majalah Ilmu Fak.kedokteran 1998;17:71–78.
Shrimpton R. Zinc Deficiency. In: Richard Semba and Martin W Bloem, editors. Nutrition and Health in Developing Countries. New Jersey: Humana Press; 2000. p. 307–26.
Linder CM. 1985. Biokimia Nutrisi dan Metabolisme. 1st ed (Terjemahan). Prakkasi A. Jakarta: Universitas Indonesia; 1992.
Sazawal S, Blak RE, Bhan MK, Bhandari N, Sinha A, Jalla S. Zinc Supplementation in Young Children with Acute Diarrhea in India. N Engl J Med 1995:13;839–44.
Roy SK, Tomkins MA, Akramuzzaman, Behrens RH, Mahalanabis D, Fuchs G. Randomized Controlled of Zinc Suplmentation in Malnourished Banglades Children with Acute Diarrhoea. Arch Dis Child 1997;77:196–200.
Partawihardja. Pengaruh Suplementasi Tempe terhadap Kecepatan Tumbuh pada Penderita Diare Anak Umur 6-24 Bulan [disertasi]. Semarang: Universitas Diponegoro; 1990.
Hidayat A. Pengaruh Pemberian Seng terhadap Diare Memanjang pada Anak Balita. Majalah Ilmu Fak. Kedokteran 1998:17;1–78.
Nelson. Ilmu Kesehatan Anak. 15th ed (Terjemahan). Siregar MR, dan Maulany RF. Jakarta: EGC; 1996.
Subowo. Imunolobiologi. Bandung: Angkasa; 1993.
Suryono A. Isu Penelitian pada Peningkatan Pola Pemberian Makanan Bayi untuk Penanggulangan Diare. Berita Kedokteran Masyarakat 1988:4(12); 327–33.
Lesmana S, Hidayat A. Kadar Hambatan Senyawa Seng Sulfat terhadap Beberapa Jenis Kuman Enteropatogen. Majalah Ilmu Kedokteran 1999;18: 53–60.
Butta ZA, Nizami SQ, Isani Z. Zinc Supplementation in Malnourished Children with Persisten. Pediatrics [series online] 1999 April;103(4):[25 screens]. Available FTP: Hostname: kfschrc.edu. sa/annals/215_216/01-017SR.pdf+&hl= en&ie= UTF-8. (1-16)
DOI: https://doi.org/10.22146/ijcn.17427
Article Metrics
Abstract views : 5582 | views : 3301Refbacks
- There are currently no refbacks.
Copyright (c) 2016 Jurnal Gizi Klinik Indonesia (The Indonesian Journal of Clinical Nutrition)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.