Perbandingan kadar nerve growth factor serum antara painful dan nonpainful diabetic neuropathy
https://doi.org/10.22146/bns.v18i1.55066 Dwi Ananda Puspitasari(1*), Ahmad Asmedi(2), Abdul Gofir(3)
(1)
(2) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(3) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
Kontroversi tentang peran nerve growth factor (NGF) terhadap patogenesis nyeri membatasi pengembangan terapi neuropati diabetika berbasis NGF. Beberapa penelitian menyebutkan bahwa NGF menimbulkan efek antinosiseptik, sementara yang lainnya menyebutkan NGF menimbulkan efek pronosiseptik. Diperlukan suatu penelitian yang dapat membantu memahami peran NGF terhadap patogenesis nyeri neuropati diabetika (painful diabetic neuropathy). Penelitian ini bertujuan untuk membandingan kadar NGF serum antara painful dan non painful diabetic neuropathy.
Penelitian ini menggunakan rancangan cross sectional, dengan subjek penelitian pasien DM tipe 2 yang telah tegak diagnosis neuropati diabetika berdasarkan klinis dan pemeriksaan elektroneuromiografi (ENMG) yang kontrol ke Poliklinik Saraf RSUP Dr. Sardjito. Painful diabetic neuropathy ditentukan berdasarkan skor ID pain. Kadar NGF serum diperiksa dengan kit reagen NGF manusia ELISA produk Abnova. Analisis statistik dengan uji t digunakan untuk menilai signifikansi dari perbandingan yang muncul. Nilai p <0,05 dianggap sebagai signifikan.
Tiga puluh enam pasien neuropati diabetika berperan dalam penelitian ini, terdiri dari 21 kasus painful diabetic neuropathy dan 15 kasus non painful diabetic neuropathy. Hasil uji statistik menunjukkan tidak terdapat perbedaan rerata kadar NGF serum antara painful dan non painful diabetic neuropathy. Meskipun demikian, terdapat korelasi negatif antara kadar NGF serum dengan skor ID pain yang berarti semakin rendah kadar NGF serum maka semakin tinggi skor ID pain (p <0,05 dan r = -0,414).
Tidak terdapat perbedaan kadar NGF serum yang signifikan antara painful dan nonpainful diabetic neuropathy.
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DOI: https://doi.org/10.22146/bns.v18i1.55066
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