Prediktor faktor kekambuhan tuberkulosis di kabupaten Bantul

Nooria Sukmaningtyas(1*), Ning Rintiswati(2), Riris Andono Ahmad(3)

(1) Departemen Biostatistik Epidemiologi dan Kesehatan Populasi Fakultas Kedokteran Universitas Gadjah Mada
(2) Pusat Kedokteran Tropis Fakultas Kedokteran Universitas Gadjah Mada
(3) Departemen Biostatistik Epidemiologi dan Kesehatan Populasi Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author


Predictors of tuberculosis recurrence in the district of Bantul


The purpose of this research was to identify associated factors of TB recurrence.


The study design was a retrospective cohort. We  used TB cases registered in Bantul regency data in 2003-2014 that consisted of 3418 patients. Sampling was conducted by non-random methods with purposive sampling based on inclusion criteria of 904 samples. The variables measured were: age, sex, drug swallowing supervisor, health service facility, socioeconomic and sputum conversion. We used the Cox proportional hazard model for data analysis to determine the rate of occurrence and timing of the occurrence of an event.


Male sex (HR = 0.91; p-value = 0.17) age> 40 years (HR = 1.03; p-value = 0.59), low income (HR = 0.89; p-value = 0.11) were not predictors of TB recurrence, while hospital treatment (HR = 0.81; p-value = 0.00), no sputum conversion (HR = 0.58; p-value = 0.00), treatment failure (HR = 0.49; 95% CI: 0.37-0.64), and treatment of less than 6 months (HR = 0.008; 95% CI: 0.00-0.07) were predictors of TB recurrence. There were 56 (6.18%) of 904 patients who experienced relapse after cured or failed treatment. The average patient relapsed after 17 months of completion of the first treatment.


Health facilities, sputum conversion, end-of-treatment status and duration of treatment are pulmonary TB recurrence factors, and as a result can be used to predict TB recurrence in the district of Bantul.


tuberculosis; recurrence; DOTS programs; retrospective cohorts


  1. Departemen Kesehatan. Pedoman Nasional Pengendalian Tuberkulosis. Jakarta : Kementerian Kesehatan RI, 2014.
  2. Lee PH, Lin HC, Huang AS, Wei SH, Lai MS, Lin HH. Diabetes and risk of tuberculosis relapse: nationwide nested case-control study. PloS one. 2014 Mar 24;9(3):e92623.
  3. Yatin D, Usha D, Chhaya D. Relapse following directly observed therapy short course (DOTS)-a follow up study. Indian journal of tuberculosis. 2000;47(4):233-6.
  4. Datiko DG, Lindtjørn B. Tuberculosis recurrence in smear-positive patients cured under DOTS in southern Ethiopia: retrospective cohort study. BMC Public Health. 2009 Dec;9(1):348.
  5. Kemenkes. Pedoman Nasional Pelayanan Kedokteran Tata Laksanan Tuberkulosis. Jakarta : Kementrian Kesehatan R1. 2013.
  6. Dooley KE, Lahlou O, Knudsen J, Elmessaoudi MD, Cherkaoui I, El Aouad R. Risk factors for tuberculosis treatment failure, default, or relapse and outcomes of retreatment in Morocco. BMC public health. 2011 Dec;11(1):140.
  7. Kleinbaum, DG, Klein, M. Survival Analysis. Atlanta : Springer. 2005.
  8. Vree M, Huong NT, Duong BD, Sy DN, Van LN, Hung NV, Co NV, Borgdorff MW, Cobelens FG. Survival and relapse rate of tuberculosis patients who successfully completed treatment in Vietnam. The International Journal of Tuberculosis and Lung Disease. 2007 Apr 1;11(4):392-7.
  9. van Rie A, Warren R, Richardson M, Victor TC, Gie RP, Enarson DA, Beyers N, van Helden PD. Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. New England Journal of Medicine. 1999 Oct 14;341(16):1174-9.
  10. Chaisson, RE, Churchyard, GJ. Recurrent Tuberculo- sis: Relapse, Reinfection, and HIV. The Journal of Infectious Disease. 2010. pp. 201: 653-655.
  11. Verver S, Warren RM, Beyers N, Richardson M, van der Spuy GD, Borgdorff MW, Enarson DA, Behr MA, van Helden PD. Rate of Infection Tuberculosis after Successful Treatment is Higher than Rate of New Tuberculosis. American Journal of Respiratory and Critical Care Medicine. 2005 pp. 171: 1430-1435.
  12. Azhar GS. DOTS for TB relapse in India: A systematic review. Lung India: official organ of Indian Chest Society. 2012 Apr;29(2):147.


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