Hubungan Rasio Netrofil Limfosit dengan Ketebalan Dinding Diafragma pada Pasien Kritis

  • Agustina Br Haloho Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Indonesia, RSUP Dr. Mohammad Hoesin - Palembang
  • Rudyanto Sedono Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo - Jakarta
  • Adhrie Sugiarto Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo - Jakarta
  • Zulkifli Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo - Jakarta
DOI: https://doi.org/10.22146/jka.v7i2.7449
Keywords: diaphragm thickness, neutrophil to lymphocyte ratio, mechanical ventilation

Abstract

Background: The cause of weaning failure is multifactorial. One of the causes was Ventilator Induced Diaphragm Dysfunction (VIDD) due to thinning process of the diaphragm thickness. Decreased diaphragm muscle mass might occur due to inflammatory process. This study was aimed to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.

Methods: This was an observational analytic study from September 2018 to January 2019 in Mohammad Hoesin Hospital, Palembang – Indonesia. Ethical appoval for the study was obtained from Ethics Committee and subjects were recruited after signing the informed consents. Only 30 subjects were involved in the end of the study. About 6 mL of blood sample from cubital vein was withdrawn from each subject to measure neutrophils and lymphocytes. Patients’ diaphragm thickness was measured by using ultrasonography on 0th, 3rd, 5th day. Collected data were then analyzed with Stata 15.

Results: The chi-square test showed that the relationship of NLR (neutophil to lymphocyte ratio) of the 0th day to the decrease in diaphragm thickness on the 3rd day was not significant (p = 0.254), while the decrease in diaphragm thickness on the 5th day was significant (p = 0.015). Subjects with initial NLR values >7 had a significant higher risk of having decreased diaphragm thickness compared to subjects with initial NLR values ≤7 (RR = 1.62 (0.99-2.64); p-value = 0.003).

Conclusion: Neutrophil to lymphocyte ratio affected the decrease of diaphragm thickness in patients using mechanical ventilation.

Published
2020-03-01
How to Cite
Haloho, A. B., Sedono, R., Sugiarto, A., & Zulkifli. (2020). Hubungan Rasio Netrofil Limfosit dengan Ketebalan Dinding Diafragma pada Pasien Kritis. Jurnal Komplikasi Anestesi, 7(2), 31-36. https://doi.org/10.22146/jka.v7i2.7449
Issue
Vol 7 No 2 (2020): Volume 7 Number 2 (2020)
Section
Articles

Copyright (c) 2020 Agustina Br Haloho, Rudyanto Sedono, Adhrie Sugiarto, Zulkifli

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