Prevalence and Risk Factors of Peripheral Arterial Disease in type 2 Diabetes Mellitus in Yogyakarta, Indonesia Prevalensi dan Faktor Risiko Penyakit Arteri pada Penderita Diabetes Mellitus Tipe 2 di Yogyakarta, Indonesia

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Muhamad Taufik Ismail
Hariadi Hariawan
Firman Fauzan Arief Lutfie
Dhite Bayu Nugroho
Vina Yanti Susanti
Vita Yanti Anggraeni
Syahdi Nugraha Kadafi
Rara Ayuningtyas
Tinanda Tarigan
Rizkan Triatmaja
I Putu Aditio Artayasa
Galih Ramadhan
Saiful Hidayat



Diabetes mellitus increases the risk of peripheral artery disease (PAD) 2 times. PAD is diagnosed by ABI (Ankle Brachial Index). PAD increases mortality and morbidity of patient with Diabetes Mellitus (DM) Type 2. This study aims to determine the prevalence and risk factors of PAD in the population of type 2 diabetes mellitus (DM) in Yogyakarta, Indonesia.



This study was a community-based descriptive and analytic observational study that examines the prevalence and risk factors of PAD in type 2 diabetes mellitus. Diagnosis of PAD was detected by ABI examination using VaSera VS-1500N. All patients with type 2 diabetes mellitus in Yogyakarta who meet the inclusion criteria will be enrolled in this study. The research subjects were taken in multi-stage, cluster-random sampling in Yogyakarta. The patient will undergo an interview of demographic data which were assessed by one assessor.  Data from interviews and ABI examinations were analysed statistically.



Two hundred and fifty-six (256) patients with type 2 DM consisted of 188 patients (73.4%) women and 68 patients (26.6%) men. Prevalence of PAD diagnosed by abnormal ABI was found in 41 (16%) of 256 patients. Subjects with age more than 67 years old was significantly associated with PAD occurrence (P=0,001) in type 2 DM population.



The prevalence of PAD was 16% of 256 type 2 DM patients. Age more than 67 years old was the strong risk factor of PAD in type 2 DM.


Key words: Ankle Brachial Index, Peripheral Arterial Disease, Diabetes mellitus, Prevalence, Risk Factor

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Research Articles


1.Agboghoroma, O. F., Akemokwe, F. M. and Puepet, F. H. (2020) ‘Peripheral arterial disease and its correlates in patients with type 2 diabetes mellitus in a teaching hospital in northern Nigeria: A cross-sectional study’, BMC Cardiovascular Disorders, 20(1), pp. 3–8. doi: 10.1186/s12872-020-01395-3.
2.Ali, Z. et al. (2012) ‘Peripheral artery disease in type II diabetes.’, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 22(11), pp. 686–689.
3.Barrera-Guarderas, F., Carrasco-Tenezaca, F. and De la Torre-Cisneros, K. (2020) ‘Peripheral Artery Disease in Type 2 Diabetes Mellitus: Survival Analysis of an Ecuadorian Population in Primary Care’, Journal of primary care & community health, 11. doi: 10.1177/2150132720957449.
4.Burger, H., & Marinček, Č. (2007). Return to work after lower limb amputation. Disability and rehabilitation, 29(17), 1323-1329.
5.Danaei, G., Finucane, M. M., Lu, Y., Singh, G. M., Cowan, M. J., Paciorek, C. J., ... & Rao, M. (2011). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2• 7 million participants. The Lancet, 378(9785), 31-40.
6.Eason, S. L. et al. (2005) ‘Diabetes mellitus, smoking, and the risk for asymptomatic peripheral arterial disease: whom should we screen?’, The Journal of the American Board of Family Practice, 18(5), pp. 355–361. doi: 10.3122/jabfm.18.5.355.
7.Kim, J. et al. (2019) ‘Trends in Lower Limb Amputation in Patients with Diabetic Foot Based on Vascular Intervention of Peripheral Arterial Disease in Korea: a Population-based Nationwide Study’, J Korean Med Sci, 34(26). Available at:
8.Li, X. et al. (2012) ‘Prevalence of and risk factors for abnormal ankle-brachial index in patients with type 2 diabetes’, Journal of Diabetes, 4(2), pp. 140–146. doi: 10.1111/j.1753-0407.2011.00171.x.
9.Makdisse, M. et al. (2007) ‘A risk score for predicting peripheral arterial disease in individuals 75 years or older’, Arquivos brasileiros de cardiologia, 88(6). doi: 10.1590/S0066-782X2007000600002.
10.Purnamasari, D. (2014). Buku ajar ilmu penyakit dalam. Edisi Ke-6. Jakarta: Papdi.
11.Fowler, M. J. (2008). Microvascular and macrovascular complications of diabetes. Clinical diabetes, 26(2), 77-82.
12.Rabia, K. and Khoo, E. M. (2007) ‘Prevalence of peripheral arterial disease in patients with diabetes mellitus in a primary care setting.’, The Medical journal of Malaysia, 62(2), pp. 130–133.
13.Rhee, S. Y. et al. (2007) ‘Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis.’, Diabetes research and clinical practice, 76(1), pp. 82–92. doi: 10.1016/j.diabres.2006.07.029.
14.Suwannasrisuk, P. et al. (2020) ‘Prevalence and predictors of peripheral arterial disease determined by ankle brachial index in diabetes population treated within primary care services in a non-urban area of lower northern Thailand’, Diabetes and Vascular Disease Research, 17(6). doi: 10.1177/1479164120966997.
15.Thiruvoipati, T. (2015) ‘Peripheral artery disease in patients with diabetes: Epidemiology, mechanisms, and outcomes’, World Journal of Diabetes, 6(7), p. 961. doi: 10.4239/wjd.v6.i7.961.
16.Tseng, C.-H. (2003) ‘Prevalence and risk factors of peripheral arterial obstructive disease in Taiwanese type 2 diabetic patients.’, Angiology, 54(3), pp. 331–338. doi: 10.1177/000331970305400309.
17.Varu, V. N., Hogg, M. E., & Kibbe, M. R. (2010). Critical limb ischemia. Journal of vascular surgery, 51(1), 230-241.
18.Vrsalovic, M. et al. (2017) ‘Impact of diabetes on mortality in peripheral artery disease: a meta-analysis’, Clinical Cardiology, 40(5), pp. 287–291. doi: 10.1002/clc.22657.
19.Wang, L. et al. (2011) ‘Prevalence and related risk factors of peripheral arterial disease in elderly patients with type 2 diabetes in Wuhan, Central China’, Chinese Medical Journal, 124(24), pp. 4264–4268. doi: 10.3760/cma.j.issn.0366-6999.2011.24.025.
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001). Global and societal implications of the diabetes epidemic. Nature, 414(6865), 782.