Knowledge, attitude, and practice on antibiotic use in DKI Jakarta during COVID-19 pandemic
Abstract
Insufficient knowledge of antibiotic use among the general public could lead to antibiotic resistance. As the COVID-19 pandemic might encourage antibiotic self-medication, a study about recent knowledge, attitude, and practice (KAP) levels on antibiotic use during the COVID-19 pandemic needs to be carried out, including its possible associated factors. It is a cross-sectional study with 420 subjects living in DKI Jakarta and aged 18 or above. A validated KAPAQ questionnaire was used. Chi-square analysis was used to analyze the correlation between KAP levels and its possible associated factors. Most subjects’ score of KAP in antibiotic use were considered high. A statistically significant correlation between knowledge and attitude (p<0.001), knowledge and practice (p<0.001), and between attitude and practice (p<0.001) was found. A statistically significant correlation between gender and occupation fields with KAP (p<0.05), education level with knowledge (p<0.05), and history of self-medication with attitude and practice (p<0.05) were found. Age, marital status, and history of COVID-19 do not show any statistically significant correlation with KAP levels. In conclusion, most subjects have a high score of KAP in antibiotic use. All three variables also show significant correlations between each other while the sociodemographic factors that correlate significantly with KAP levels are gender, occupation field, education level, and history of self-medication with antibiotics.
References
Patel P, Wermuth HR, Calhoun C, Hall GA. Antibiotics. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
http://www.ncbi.nlm.nih.gov/books/NBK535443/
Interagency Coordination Group on Antimicrobial Resistance. No time to Wait: Securing the future from drug-resistant infections. Interagency Coordination Group on Antimicrobial Resistance; 2019 Apr. (Report to the Secretary-General of the United Nations).
Andrajati R, Tilaqza A, Supardi S. Factors related to rational antibiotic prescriptions in community health centers in Depok City, Indonesia. J Infect Public Health 2017; 10(1):41-8.
https://doi.org/10.1016/j.jiph.2016.01.012
Awad AI, Aboud EA. Knowledge, attitude and practice towards antibiotic use among the public in Kuwait. PloS One 2015; 10(2):e0117910.
https://doi.org/10.1371/journal.pone.0117910
Choo SJ, Chang CT, Lee JCY, Munisamy V, Tan CK, Raj JD, et al. A cross-sectional study on public belief, knowledge and practice towards antibiotic use in the state of Perak, Malaysia. J Infect Dev Ctries 2018; 12(11):960-9.
https://doi.org/10.3855/jidc.10723
Karuniawati H, Hassali MAA, Suryawati S, Ismail WI, Taufik T, Hossain MS. Assessment of Knowledge, Attitude, and Practice of Antibiotic Use among the Population of Boyolali, Indonesia: A Cross-Sectional Study. Int J Environ Res Public Health 2021; 18(16):8258.
https://doi.org/10.3390/ijerph18168258
Nepal A, Hendrie D, Robinson S, Selvey LA. Knowledge, attitudes and practices relating to antibiotic use among community members of the Rupandehi District in Nepal. BMC Public Health 2019; 19(1):1558.
https://doi.org/10.1186/s12889-019-7924-5
Widayati A, Suryawati S, de Crespigny C, Hiller JE. Knowledge and beliefs about antibiotics among people in Yogyakarta City Indonesia: a cross sectional population-based survey. Antimicrob Resist Infect Control 2012; 1(1):38.
https://doi.org/10.1186/2047-2994-1-38
Kosiyaporn H, Chanvatik S, Issaramalai T, Kaewkhankhaeng W, Kulthanmanusorn A, Saengruang N, et al. Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review. PloS One 2020; 15(1):e0227973.
https://doi.org/10.1371/journal.pone.0227973
Badran IG. Knowledge, attitude and practice the three pillars of excellence and wisdom: a place in the medical profession. EMHJ - East Mediterr Health J 1995: 1:8-16.
https://iris.who.int/handle/10665/116905
Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed 2020; 91(1):157-60.
https://doi.org/10.23750/abm.v91i1.9397
WHO. COVID-19 Weekly Epidemiological Update. World Health Organization; 2022. (COVID-19 Weekly Epidemiological Update). Report No.: 123.
Nieuwlaat R, Mbuagbaw L, Mertz D, Burrows LL, Bowdish DME, Moja L, et al. Coronavirus Disease 2019 and Antimicrobial Resistance: Parallel and Interacting Health Emergencies. Clin Infect Dis 2021; 72(9):1657-9.
https://doi.org/10.1093/cid/ciaa773
Dahal D, Sundar S, Kullar R, Milevska-Kostova N, Dindial K. Antimicrobial resistance during the COVID-19 pandemic: the missing patient perspective. JAC Antimicrob Resist 2021; 3(1):dlab030.
https://doi.org/10.1093/jacamr/dlab030
Malik M, Tahir MJ, Jabbar R, Ahmed A, Hussain R. Self-medication during Covid-19 pandemic: challenges and opportunities. Drugs Ther Perspect Ration Drug Sel Use 2020; 36(12):565-7.
https://doi.org/10.1007/s40267-020-00785-z
Monnet DL, Harbarth S. Will coronavirus disease (COVID-19) have an impact on antimicrobial resistance? Euro Surveill 2020; 25(45):2001886.
https://doi.org/10.2807/1560-7917.ES.2020.25.45.2001886
Rawson TM, Ming D, Ahmad R, Moore LSP, Holmes AH. Antimicrobial use, drug-resistant infections and COVID-19. Nat Rev Microbiol 2020; 18(8):409-10.
https://doi.org/10.1038/s41579-020-0395-y
Rawson TM, Moore LSP, Castro-Sanchez E, Charani E, Davies F, Satta G, et al. COVID-19 and the potential long-term impact on antimicrobial resistance. J Antimicrob Chemother 2020; 75(7):1681-4.
https://doi.org/10.1093/jac/dkaa194
Pogurschi EN, Petcu CD, Mizeranschi AE, Zugravu CA, Cirnatu D, Pet I, et al. Knowledge, Attitudes and Practices Regarding Antibiotic Use and Antibiotic Resistance: A Latent Class Analysis of a Romanian Population. Int J Environ Res Public Health 2022; 19(12):7263.
https://doi.org/10.3390/ijerph19127263
Khoshgoftar M, Zamani-Alavijeh F, Kasaian N, Shahzamani K, Rostami S, Nakhodian Z, et al. The effect of public health educational campaign regarding antibiotic use and microbial resistance on knowledge, attitude, and practice in the Iran. J Educ Health Promot 2021; 10:3.
https://doi.org/10.4103/jehp.jehp_629_20
Parathon H, Kuntaman K, Widiastoety TH, Muliawan BT, Karuniawati A, Qibtiyah M, et al. Progress towards antimicrobial resistance containment and control in Indonesia. BMJ 2017; 358:j3808.
https://doi.org/10.1136/bmj.j3808
Ferdiana A, Liverani M, Khan M, Wulandari LPL, Mashuri YA, Batura N, et al. Community pharmacies, drug stores, and antibiotic dispensing in Indonesia: a qualitative study. BMC Public Health 2021; 21(1):1800.
https://doi.org/10.1186/s12889-021-11885-4
Kondoj IV, Lolo WA, Jayanto I. Pengaruh tingkat pengetahuan dan sikap terhadap penggunaan antibiotik di apotek kimia farma 396 tuminting kota manado. PHARMACON. 2020; 9(2):294-301.
https://doi.org/10.35799/pha.9.2020.29284
Gillani AH, Chang J, Aslam F, Saeed A, Shukar S, Khanum F, et al. Public knowledge, attitude, and practice regarding antibiotics use in Punjab, Pakistan: a cross-sectional study. Expert Rev Anti Infect Ther 2021; 19(3):399-411.
https://doi.org/ 10.1080/14787210.2021.1823216
Kementrian Kesehatan. Profil Kesehatan Indonesia 2021. Jakarta: Kementrian Kesehatan Republik Indonesia; 2021. (Profil Kesehatan Indonesia).