EFFECTIVENESS TEST OF SCGE-SNEDDS USED VCO AS CARRIER OIL ON CYTOKINE EXPRESSION IN VITRO
Keywords:
SNEDDS, Single clove Garlic Extract (SCGE), VCO, Cytokine
Abstract
Single clove Garlic Extract (SCGE) is a potential agent for anti-inflammation, several bioactive are lipophilic, volatile. A novel drug delivery system is required to preserve the bioactive and enhance the solubility. Self Nanoemulsfying Drug Delivery System (SNEDDS) can load extract that formed from carrier oil (VCO), surfactant (Tween-80), and co-surfactant (Glycerol), SCGE-SNEDDS prepared by mixing the surfactant and co-surfactant and adding the carrier oil with SCGE (20 mg/ml). The characteristics response emulsification time in 73.82 ± 0.91 second, % transmittance value of 78.86 ± 0.23%, and pH of 6.83 ± 0.72. The average particle size was 0.46 ± 0.01, Z-Average 23.10 ± 0.69, and zeta potential -33.07 ± 0.45 mV. The toxicity assay was determined in the 3T3-L1 cell line using MTT. The dose SCGE-SNEDDS in rank 62.5, 125, 250, 500, 1000, 2000 and 4000 µg/mL. SCGE-SNEDDS have a good response, characteristics, proved to be non-cytotoxic, and high cell viability (83.3 %). SCGE-SNEDDS had potential effect on the expression of TNF-α, not potential decreases IL-1β and increases IL-10 cytokines in 3T3-L1 cells.
References
Abdulredha, M. M., Hussain, S. A., & Abdullah, L. C. (2019). Separation emulsion via non-ionic surfactant: An optimization. Processes, 7(6). https://doi.org/10.3390/PR7060382
Alghananim, A., Özalp, Y., Mesut, B., Serakinci, N., Özsoy, Y., & Güngör, S. (n.d.). A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies. https://doi.org/10.3390/ph13080162
Ali, H. H., & Hussein, A. A. (2017). Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies. AAPS Open, 3(4), 1–16. https://doi.org/10.1186/s41120-017-0016-7
Baloch, J., Sohail, M. F., Sarwar, H. S., Kiani, M. H., Khan, G. M., Jahan, S., Rafay, M., Chaudhry, M. T., Yasinzai, M., & Shahnaz, G. (2019). Self-nanoemulsifying drug delivery system (Snedds) for improved oral bioavailability of chlorpromazine: In vitro and in vivo evaluation. Medicina (Lithuania), 55(5), 1–13. https://doi.org/10.3390/medicina55050210
Binsi, P. K., Ravishankar, C. N., & Srinivasa Gopal, T. K. (2013). Development and Characterization of an Edible Composite Film Based on Chitosan and Virgin Coconut Oil with Improved Moisture Sorption Properties. Journal of Food Science, 78(4). https://doi.org/10.1111/1750-3841.12084
Buya, A. B., Beloqui, A., Memvanga, P. B., & Préat, V. (2020). Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery. Pharmaceutics, 12(12), 1–52. https://doi.org/10.3390/pharmaceutics12121194
Chen, Y. S., Chiu, Y. H., Li, Y. S., Lin, E. Y., Hsieh, D. K., Lee, C. H., Huang, M. H., Chuang, H. M., Lin, S. Z., Harn, H. J., & Chiou, T. W. (2019). Integration of PEG 400 into a self-nanoemulsifying drug delivery system improves drug loading capacity and nasal mucosa permeability and prolongs the survival of rats with malignant brain tumors. International Journal of Nanomedicine, 14, 3601–3613. https://doi.org/10.2147/IJN.S193617
Cheng, A.-W., Tan, X., Sun, J.-Y., Gu, C.-M., Liu, C., & Guo, X. (2019). Catechin attenuates TNF-α induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes. PLOS ONE, 14(5), e0217090. https://doi.org/10.1371/journal.pone.0217090
Danaei, M., Dehghankhold, M., Ataei, S., Davarani, F. H., Javanmard, R., Dokhani, A., Khorasani, S., & Id, M. R. M. (2018). Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. 1–17. https://doi.org/10.3390/pharmaceutics10020057
Del Valle, D. M., Kim-Schulze, S., Huang, H. H., Beckmann, N. D., Nirenberg, S., Wang, B., Lavin, Y., Swartz, T. H., Madduri, D., Stock, A., Marron, T. U., Xie, H., Patel, M., Tuballes, K., Van Oekelen, O., Rahman, A., Kovatch, P., Aberg, J. A., Schadt, E., … Gnjatic, S. (2020). An inflammatory cytokine signature predicts COVID-19 severity and survival. Nature Medicine, 26(10), 1636–1643. https://doi.org/10.1038/s41591-020-1051-9
Dhingra, S., Sharma, A. K., Arora, R. C., Slezak, J., & Singal, P. K. (2009). IL-10 attenuates TNF- a -induced NF k B pathway activation and cardiomyocyte apoptosis. 59–66. https://doi.org/10.1093/cvr/cvp040
Dou, Y., Wang, T., Huang, Y., Ping, V., Xie, Y., Lin, X., Gao, J., Su, Z., & Zeng, H. (2018). Self-nanoemulsifying drug delivery system of bruceine D : a new approach for anti-ulcerative colitis. International Journal of Nanomedicine, 13, 5887–5907.
Eid, A. M., El-Enshasy, H. A., Aziz, R., & Elmarzugi, N. A. (2014). The preparation and evaluation of self-nanoemulsifying systems containing swietenia oil and an examination of its anti-inflammatory effects. International Journal of Nanomedicine, 9(1), 4685–4695. https://doi.org/10.2147/IJN.S66180
Feng, Y., Zhu, X., Wang, Q., Jiang, Y., Shang, H., Cui, L., & Cao, Y. (2012). Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malaria Journal, 11. https://doi.org/10.1186/1475-2875-11-268
Ferioli, F., Giambanelli, E., D’Alessandro, V., & D’Antuono, L. F. (2020). Comparison of two extraction methods (high pressure extraction vs. maceration) for the total and relative amount of hydrophilic and lipophilic organosulfur compounds in garlic cloves and stems. An application to the Italian ecotype “Aglio Rosso di Sulmona. Food Chemistry, 312(December 2019), 126086. https://doi.org/10.1016/j.foodchem.2019.126086
Galvão, K. C. S., Vicente, A. A., & Sobral, P. J. A. (2018). Development, Characterization, and Stability of O/W Pepper Nanoemulsions Produced by High-Pressure Homogenization. Food and Bioprocess Technology, 11(2), 355–367. https://doi.org/10.1007/s11947-017-2016-y
Gao, Y., Tu, D., Yang, R., Chu, C., & Hong, J. (2020). Through Reducing ROS Production , IL-10 Suppresses Caspase-1-Dependent IL-1 β Maturation , thereby Preventing Chronic Neuroinflammation and Neurodegeneration. 10, 1–15.
Gruhlke, M. C. H., Nicco, C., Batteux, F., & Slusarenko, A. J. (2017). The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants, 6(1), 1–16. https://doi.org/10.3390/antiox6010001
Hall, A., Troupin, A., Londono-Renteria, B., & Colpitts, T. M. (2017). Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection. Viruses, 12(9), 1–10. https://doi.org/10.3390/v9070159
Hidajat, M. J., Jo, W., Kim, H., & Noh, J. (2020). Effective Droplet Size Reduction and Excellent Stability of Limonene Nanoemulsion Formed by High-Pressure Homogenizer. Colloids and Interfaces, 4(1), 5. https://doi.org/10.3390/colloids4010005
Izham, N. M. M., Hussin, Y., Nazirul, M., Aziz, M., Yeap, S. K., Rahman, H. S., & Ja, M. (2019). Preparation and characterization of self nano-emulsifying drug delivery system loaded with citraland its antiproliferative effect on colorectal cells in vitro. Nanomaterials, 9(1028), 1–18.
Juge-Aubry, C. E., Somm, E., Pernin, A., Alizadeh, N., Giusti, V., Dayer, J. M., & Meier, C. A. (2005). Adipose tissue is a regulated source of interleukin-10. Cytokine, 29(6), 270–274. https://doi.org/10.1016/j.cyto.2004.10.017
Kaneko, N., Kurata, M., Yamamoto, T., Morikawa, S., & Masumoto, J. (2019). The role of interleukin-1 in general pathology. Inflammation and Regeneration, 39(1), 1–16. https://doi.org/10.1186/s41232-019-0101-5
Kazi, M., Al-Swairi, M., Ahmad, A., Raish, M., Alanazi, F. K., Badran, M. M., Khan, A. A., Alanazi, A. M., & Hussain, M. D. (2019). Evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for poorly water-soluble talinolol: Preparation, in vitroand in vivoAssessment. Frontiers in Pharmacology, 10(MAY), 1–13. https://doi.org/10.3389/fphar.2019.00459
Kazi, M., Shahba, A. A., Alrashoud, S., Alwadei, M., Sherif, A. Y., & Alanazi, F. K. (2020). Bioactive self-nanoemulsifying drug delivery systems (Bio-SNEDDS) for combined oral delivery of curcumin and piperine. Molecules, 25(7), 1–24. https://doi.org/10.3390/molecules25071703
Khan, A. W., Kotta, S., Ansari, S. H., Sharma, R. K., & Ali, J. (2015). Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: Design, characterization, in vitro and in vivo evaluation. Drug Delivery, 22(4), 552–561. https://doi.org/10.3109/10717544.2013.878003
Kim, D., Cheon, J., Yoon, H., & Jun, H. (2021). Cudrania tricuspidata Root Extract Prevents Methylglyoxal- Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells. 2021.
Kim, J. H., Lee, S., & Cho, E. J. (2020). Flavonoids from Acer okamotoanum Inhibit Adipocyte Differentiation and Promote Lipolysis in the 3T3-L1 Cells. Molecules, 25, 1–13.
Kothari, D., Lee, W., & Kim, S. (2020). Allium Flavonols : Health Benefits , Molecular Targets , and Bioavailability.
Lagathu, C., Yvan-Charvet, L., Bastard, J.-P., Maachi, M., Quignard-Boulangé, A., Capeau, J., Caron, M., & Maachi, : M. (n.d.). Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes acetyl-CoA carboxylase FABP4 adipocyte-specific fatty acid binding protein 4 C/EBP CCAAT/enhancer-binding protein ERK extracellular regulated kinase FASN fatty acid synthase HF high fat HOMA-IR homeostasis model assessment-insulin resistance IR insulin receptor IRS insulin receptor substrate. https://doi.org/10.1007/s00125-006-0335-z
Lestari, S. R., & Rifa’i, M. (2018). Regulatory T cells and anti-inflammatory cytokine profile of mice fed a high-fat diet after single-bulb garlic (Allium sativum L.) oil treatment. Tropical Journal of Pharmaceutical Research, 17(11), 2157–2162. https://doi.org/10.4314/tjpr.v17i11.7
Li, D.-Q., Luo, L., Chen, Z., Kim, H.-S., Song, X. J., & Pflugfelder, S. C. (2006). JNK and ERK MAP kinases mediate induction of IL-1β, TNF-α and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res, 4(82), 588–596.
Liu, J., Zheng, X., Tong, Q., Li, W., Wang, B., Sutter, K., Trilling, M., Lu, M., Dittmer, U., & Yang, D. (2020). Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. Journal of Medical Virology, 92(5), 491–494. https://doi.org/10.1002/jmv.25709
Metwally, M. A. A. (2009). Effects of Garlic (Allium sativum) on Some Antioxidant Activities in Tilapia Nilotica (Oreochromis niloticus). World Journal of Fish and Marine Sciences, 1(1), 56–64.
Milhomem-Paixão, S. S. R., Fascineli, M. L., Muehlmann, L. A., Melo, K. M., Salgado, H. L. C., Joanitti, G. A., Pieczarka, J. C., Azevedo, R. B., Santos, A. S., & Grisolia, C. K. (2017). Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity. Journal of Nanomaterials, 2017. https://doi.org/10.1155/2017/4362046
Nasr, A., Gardouh, A., & Ghorab, M. (2016). Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: Design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics, 8(3). https://doi.org/10.3390/pharmaceutics8030020
Occhiutto, M. L., Maranhão, R. C., Costa, V. P., & Konstas, A. G. (2020). Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review. Advances in Therapy, 37(1), 155–199. https://doi.org/10.1007/s12325-019-01163-6
Ogawa, A., Fujimoto, K., Hayashi, A., Chida, S., & Sato, K. (2014). Peptides Physiological fluctuations of human plasma total salusin-  , an endogenous parasympathomimetic / proatherosclerotic peptide. Peptides, 59, 83–88. https://doi.org/10.1016/j.peptides.2014.07.009
Petrovska, B., & Cekovska, S. (2010). Extracts from the history and medical properties of garlic. In Pharmacognosy Reviews (Vol. 4, Issue 7, pp. 106–110). Wolters Kluwer -- Medknow Publications. https://doi.org/10.4103/0973-7847.65321
Polychniatou, V., & Tzia, C. (2014). Study of formulation and stability of co-surfactant free water-in-olive oil nano- and submicron emulsions with food grade non-ionic surfactants. JAOCS, Journal of the American Oil Chemists’ Society, 91(1), 79–88. https://doi.org/10.1007/s11746-013-2356-3
Pratiwi, L., Fudholi, A., Martien, R., & Pramono, S. (2017). Self-nanoemulsifying drug delivery system (Snedds) for topical delivery of mangosteen peels (Garcinia Mangostana l.,): Formulation design and in vitro studies. Journal of Young Pharmacists, 9(3), 341–346. https://doi.org/10.5530/jyp.2017.9.68
Senapati, P. C., Sahoo, S. K., & Sahu, A. N. (2016). Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomedicine and Pharmacotherapy, 80, 42–51. https://doi.org/10.1016/j.biopha.2016.02.039
Shang, A., Cao, S. Y., Xu, X. Y., Gan, R. Y., Tang, G. Y., Corke, H., Mavumengwana, V., & Li, H. Bin. (2019). Bioactive compounds and biological functions of garlic (allium sativum L.). In Foods (Vol. 8, Issue 7). MDPI Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/foods8070246
Tabari, K., Hosseinpour, S., Pareshet, P., Khozestani, P. K., & Rahimi, H. M. (2017). Cytotoxicity of selected nanoparticles on human dental pulp stem cells. Iranian Endodontic Journal, 12(2), 137–142. https://doi.org/10.7508/iej.2017.02.003
Torres-Palazzolo, C., Ramirez, D., Locatelli, D., Manucha, W., Castro, C., & Camargo, A. (2018). Bioaccessibility and permeability of bioactive compounds in raw and cooked garlic. Journal of Food Composition and Analysis, 70, 49–53. https://doi.org/10.1016/j.jfca.2018.03.008
Ujilestari, T., Danar Dono, N., Ariyadi, B., Martien, R., & Zuprizal, Z. (2018). Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil. Malaysian Journal of Fundamental and Applied Sciences, 14(3), 360–363. https://doi.org/10.11113/mjfas.v14n3.1070
Ujilestari, T., Martien, R., Ariyadi, B., Dono, N. D., & Zuprizal. (2018). Self-nanoemulsifying drug delivery system (SNEDDS) of Amomum compactum essential oil: Design, formulation, and characterization. Journal of Applied Pharmaceutical Science, 8(6), 14–21. https://doi.org/10.7324/JAPS.2018.8603
Untari, I. (2010). Bawang Putih Sebagai Obat Paling Mujarab Bagi Kesehatan. Gaster | Jurnal Ilmu Kesehatan, 7(1), 547–554.
Vemuri, S. K., Banala, R. R., GPV, S., AV, G. R., & Thekkumalai, M. (2018). Apoptotic efficiency of aqueous extracts of turmeric, garlic and their active compounds in combination with Tamoxifen in lung and oral cancers: A comparative study. Beni-Suef University Journal of Basic and Applied Sciences, 7(2), 184–197. https://doi.org/10.1016/j.bjbas.2017.10.006
Vulesevic, B., McNeill, B., Giacco, F., Maeda, K., Blackburn, N. J. R., Brownlee, M., Milne, R. W., & Suuronen, E. J. (2016). Methylglyoxal-induced endothelial cell loss and inflammation contribute to the development of diabetic cardiomyopathy. Diabetes, 65(6), 1699–1713. https://doi.org/10.2337/db15-0568
Wang, Y., Hall, L. M., Kujawa, M., Li, H., Zhang, X., Meara, M. O., Ichinose, X. T., Wang, J., Wang, Y., Lm, H., Kujawa, M., Li, H., Zhang, X., Meara, O. M., Ichinose, T., & Jm, W. (2021). Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K ATP / MAPK pathway. 68–81. https://doi.org/10.1152/ajpcell.00117.2018
Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014). The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators of Inflammation, 2014. https://doi.org/10.1155/2014/561459
Yin, H. F., Yin, C. M., Ouyang, T., Sun, S. D., Chen, W. G., Yang, X. L., He, X., & Zhang, C. F. (2021). Self-nanoemulsifying drug delivery system of genkwanin: A novel approach for anti-colitis-associated colorectal cancer. Drug Design, Development and Therapy, 15, 557–576. https://doi.org/10.2147/DDDT.S292417
Zhang, L., Zhang, L., Zhang, M., Pang, Y., Li, Z., Zhao, A., & Feng, J. (2015). Self-emulsifying drug delivery system and the applications in herbal drugs. Drug Delivery, 22(4), 475–486. https://doi.org/10.3109/10717544.2013.861659
Zhang, M., Pan, H., Xu, Y., Wang, X., Qiu, Z., & Jiang, L. (2017). Allicin decreases lipopolysaccharide-induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2. Cellular Physiology and Biochemistry, 41(6), 2255–2267. https://doi.org/10.1159/000475640
Zhou, Y., Liu, B. L., Liu, K., Tang, N., Huang, J., An, Y., & Li, L. (2008). Establishment of the insulin resistance induced by inflammatory response in 3T3-L1 preadipocytes cell line. Inflammation, 31(5), 355–364. https://doi.org/10.1007/s10753-008-9086-y
Zorzi, G. K., Carvalho, E. L. S., Von Poser, G. L., & Teixeira, H. F. (2015). On the us
Alghananim, A., Özalp, Y., Mesut, B., Serakinci, N., Özsoy, Y., & Güngör, S. (n.d.). A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies. https://doi.org/10.3390/ph13080162
Ali, H. H., & Hussein, A. A. (2017). Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies. AAPS Open, 3(4), 1–16. https://doi.org/10.1186/s41120-017-0016-7
Baloch, J., Sohail, M. F., Sarwar, H. S., Kiani, M. H., Khan, G. M., Jahan, S., Rafay, M., Chaudhry, M. T., Yasinzai, M., & Shahnaz, G. (2019). Self-nanoemulsifying drug delivery system (Snedds) for improved oral bioavailability of chlorpromazine: In vitro and in vivo evaluation. Medicina (Lithuania), 55(5), 1–13. https://doi.org/10.3390/medicina55050210
Binsi, P. K., Ravishankar, C. N., & Srinivasa Gopal, T. K. (2013). Development and Characterization of an Edible Composite Film Based on Chitosan and Virgin Coconut Oil with Improved Moisture Sorption Properties. Journal of Food Science, 78(4). https://doi.org/10.1111/1750-3841.12084
Buya, A. B., Beloqui, A., Memvanga, P. B., & Préat, V. (2020). Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery. Pharmaceutics, 12(12), 1–52. https://doi.org/10.3390/pharmaceutics12121194
Chen, Y. S., Chiu, Y. H., Li, Y. S., Lin, E. Y., Hsieh, D. K., Lee, C. H., Huang, M. H., Chuang, H. M., Lin, S. Z., Harn, H. J., & Chiou, T. W. (2019). Integration of PEG 400 into a self-nanoemulsifying drug delivery system improves drug loading capacity and nasal mucosa permeability and prolongs the survival of rats with malignant brain tumors. International Journal of Nanomedicine, 14, 3601–3613. https://doi.org/10.2147/IJN.S193617
Cheng, A.-W., Tan, X., Sun, J.-Y., Gu, C.-M., Liu, C., & Guo, X. (2019). Catechin attenuates TNF-α induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes. PLOS ONE, 14(5), e0217090. https://doi.org/10.1371/journal.pone.0217090
Danaei, M., Dehghankhold, M., Ataei, S., Davarani, F. H., Javanmard, R., Dokhani, A., Khorasani, S., & Id, M. R. M. (2018). Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. 1–17. https://doi.org/10.3390/pharmaceutics10020057
Del Valle, D. M., Kim-Schulze, S., Huang, H. H., Beckmann, N. D., Nirenberg, S., Wang, B., Lavin, Y., Swartz, T. H., Madduri, D., Stock, A., Marron, T. U., Xie, H., Patel, M., Tuballes, K., Van Oekelen, O., Rahman, A., Kovatch, P., Aberg, J. A., Schadt, E., … Gnjatic, S. (2020). An inflammatory cytokine signature predicts COVID-19 severity and survival. Nature Medicine, 26(10), 1636–1643. https://doi.org/10.1038/s41591-020-1051-9
Dhingra, S., Sharma, A. K., Arora, R. C., Slezak, J., & Singal, P. K. (2009). IL-10 attenuates TNF- a -induced NF k B pathway activation and cardiomyocyte apoptosis. 59–66. https://doi.org/10.1093/cvr/cvp040
Dou, Y., Wang, T., Huang, Y., Ping, V., Xie, Y., Lin, X., Gao, J., Su, Z., & Zeng, H. (2018). Self-nanoemulsifying drug delivery system of bruceine D : a new approach for anti-ulcerative colitis. International Journal of Nanomedicine, 13, 5887–5907.
Eid, A. M., El-Enshasy, H. A., Aziz, R., & Elmarzugi, N. A. (2014). The preparation and evaluation of self-nanoemulsifying systems containing swietenia oil and an examination of its anti-inflammatory effects. International Journal of Nanomedicine, 9(1), 4685–4695. https://doi.org/10.2147/IJN.S66180
Feng, Y., Zhu, X., Wang, Q., Jiang, Y., Shang, H., Cui, L., & Cao, Y. (2012). Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malaria Journal, 11. https://doi.org/10.1186/1475-2875-11-268
Ferioli, F., Giambanelli, E., D’Alessandro, V., & D’Antuono, L. F. (2020). Comparison of two extraction methods (high pressure extraction vs. maceration) for the total and relative amount of hydrophilic and lipophilic organosulfur compounds in garlic cloves and stems. An application to the Italian ecotype “Aglio Rosso di Sulmona. Food Chemistry, 312(December 2019), 126086. https://doi.org/10.1016/j.foodchem.2019.126086
Galvão, K. C. S., Vicente, A. A., & Sobral, P. J. A. (2018). Development, Characterization, and Stability of O/W Pepper Nanoemulsions Produced by High-Pressure Homogenization. Food and Bioprocess Technology, 11(2), 355–367. https://doi.org/10.1007/s11947-017-2016-y
Gao, Y., Tu, D., Yang, R., Chu, C., & Hong, J. (2020). Through Reducing ROS Production , IL-10 Suppresses Caspase-1-Dependent IL-1 β Maturation , thereby Preventing Chronic Neuroinflammation and Neurodegeneration. 10, 1–15.
Gruhlke, M. C. H., Nicco, C., Batteux, F., & Slusarenko, A. J. (2017). The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants, 6(1), 1–16. https://doi.org/10.3390/antiox6010001
Hall, A., Troupin, A., Londono-Renteria, B., & Colpitts, T. M. (2017). Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection. Viruses, 12(9), 1–10. https://doi.org/10.3390/v9070159
Hidajat, M. J., Jo, W., Kim, H., & Noh, J. (2020). Effective Droplet Size Reduction and Excellent Stability of Limonene Nanoemulsion Formed by High-Pressure Homogenizer. Colloids and Interfaces, 4(1), 5. https://doi.org/10.3390/colloids4010005
Izham, N. M. M., Hussin, Y., Nazirul, M., Aziz, M., Yeap, S. K., Rahman, H. S., & Ja, M. (2019). Preparation and characterization of self nano-emulsifying drug delivery system loaded with citraland its antiproliferative effect on colorectal cells in vitro. Nanomaterials, 9(1028), 1–18.
Juge-Aubry, C. E., Somm, E., Pernin, A., Alizadeh, N., Giusti, V., Dayer, J. M., & Meier, C. A. (2005). Adipose tissue is a regulated source of interleukin-10. Cytokine, 29(6), 270–274. https://doi.org/10.1016/j.cyto.2004.10.017
Kaneko, N., Kurata, M., Yamamoto, T., Morikawa, S., & Masumoto, J. (2019). The role of interleukin-1 in general pathology. Inflammation and Regeneration, 39(1), 1–16. https://doi.org/10.1186/s41232-019-0101-5
Kazi, M., Al-Swairi, M., Ahmad, A., Raish, M., Alanazi, F. K., Badran, M. M., Khan, A. A., Alanazi, A. M., & Hussain, M. D. (2019). Evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for poorly water-soluble talinolol: Preparation, in vitroand in vivoAssessment. Frontiers in Pharmacology, 10(MAY), 1–13. https://doi.org/10.3389/fphar.2019.00459
Kazi, M., Shahba, A. A., Alrashoud, S., Alwadei, M., Sherif, A. Y., & Alanazi, F. K. (2020). Bioactive self-nanoemulsifying drug delivery systems (Bio-SNEDDS) for combined oral delivery of curcumin and piperine. Molecules, 25(7), 1–24. https://doi.org/10.3390/molecules25071703
Khan, A. W., Kotta, S., Ansari, S. H., Sharma, R. K., & Ali, J. (2015). Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: Design, characterization, in vitro and in vivo evaluation. Drug Delivery, 22(4), 552–561. https://doi.org/10.3109/10717544.2013.878003
Kim, D., Cheon, J., Yoon, H., & Jun, H. (2021). Cudrania tricuspidata Root Extract Prevents Methylglyoxal- Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells. 2021.
Kim, J. H., Lee, S., & Cho, E. J. (2020). Flavonoids from Acer okamotoanum Inhibit Adipocyte Differentiation and Promote Lipolysis in the 3T3-L1 Cells. Molecules, 25, 1–13.
Kothari, D., Lee, W., & Kim, S. (2020). Allium Flavonols : Health Benefits , Molecular Targets , and Bioavailability.
Lagathu, C., Yvan-Charvet, L., Bastard, J.-P., Maachi, M., Quignard-Boulangé, A., Capeau, J., Caron, M., & Maachi, : M. (n.d.). Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes acetyl-CoA carboxylase FABP4 adipocyte-specific fatty acid binding protein 4 C/EBP CCAAT/enhancer-binding protein ERK extracellular regulated kinase FASN fatty acid synthase HF high fat HOMA-IR homeostasis model assessment-insulin resistance IR insulin receptor IRS insulin receptor substrate. https://doi.org/10.1007/s00125-006-0335-z
Lestari, S. R., & Rifa’i, M. (2018). Regulatory T cells and anti-inflammatory cytokine profile of mice fed a high-fat diet after single-bulb garlic (Allium sativum L.) oil treatment. Tropical Journal of Pharmaceutical Research, 17(11), 2157–2162. https://doi.org/10.4314/tjpr.v17i11.7
Li, D.-Q., Luo, L., Chen, Z., Kim, H.-S., Song, X. J., & Pflugfelder, S. C. (2006). JNK and ERK MAP kinases mediate induction of IL-1β, TNF-α and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res, 4(82), 588–596.
Liu, J., Zheng, X., Tong, Q., Li, W., Wang, B., Sutter, K., Trilling, M., Lu, M., Dittmer, U., & Yang, D. (2020). Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. Journal of Medical Virology, 92(5), 491–494. https://doi.org/10.1002/jmv.25709
Metwally, M. A. A. (2009). Effects of Garlic (Allium sativum) on Some Antioxidant Activities in Tilapia Nilotica (Oreochromis niloticus). World Journal of Fish and Marine Sciences, 1(1), 56–64.
Milhomem-Paixão, S. S. R., Fascineli, M. L., Muehlmann, L. A., Melo, K. M., Salgado, H. L. C., Joanitti, G. A., Pieczarka, J. C., Azevedo, R. B., Santos, A. S., & Grisolia, C. K. (2017). Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity. Journal of Nanomaterials, 2017. https://doi.org/10.1155/2017/4362046
Nasr, A., Gardouh, A., & Ghorab, M. (2016). Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: Design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics, 8(3). https://doi.org/10.3390/pharmaceutics8030020
Occhiutto, M. L., Maranhão, R. C., Costa, V. P., & Konstas, A. G. (2020). Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review. Advances in Therapy, 37(1), 155–199. https://doi.org/10.1007/s12325-019-01163-6
Ogawa, A., Fujimoto, K., Hayashi, A., Chida, S., & Sato, K. (2014). Peptides Physiological fluctuations of human plasma total salusin-  , an endogenous parasympathomimetic / proatherosclerotic peptide. Peptides, 59, 83–88. https://doi.org/10.1016/j.peptides.2014.07.009
Petrovska, B., & Cekovska, S. (2010). Extracts from the history and medical properties of garlic. In Pharmacognosy Reviews (Vol. 4, Issue 7, pp. 106–110). Wolters Kluwer -- Medknow Publications. https://doi.org/10.4103/0973-7847.65321
Polychniatou, V., & Tzia, C. (2014). Study of formulation and stability of co-surfactant free water-in-olive oil nano- and submicron emulsions with food grade non-ionic surfactants. JAOCS, Journal of the American Oil Chemists’ Society, 91(1), 79–88. https://doi.org/10.1007/s11746-013-2356-3
Pratiwi, L., Fudholi, A., Martien, R., & Pramono, S. (2017). Self-nanoemulsifying drug delivery system (Snedds) for topical delivery of mangosteen peels (Garcinia Mangostana l.,): Formulation design and in vitro studies. Journal of Young Pharmacists, 9(3), 341–346. https://doi.org/10.5530/jyp.2017.9.68
Senapati, P. C., Sahoo, S. K., & Sahu, A. N. (2016). Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomedicine and Pharmacotherapy, 80, 42–51. https://doi.org/10.1016/j.biopha.2016.02.039
Shang, A., Cao, S. Y., Xu, X. Y., Gan, R. Y., Tang, G. Y., Corke, H., Mavumengwana, V., & Li, H. Bin. (2019). Bioactive compounds and biological functions of garlic (allium sativum L.). In Foods (Vol. 8, Issue 7). MDPI Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/foods8070246
Tabari, K., Hosseinpour, S., Pareshet, P., Khozestani, P. K., & Rahimi, H. M. (2017). Cytotoxicity of selected nanoparticles on human dental pulp stem cells. Iranian Endodontic Journal, 12(2), 137–142. https://doi.org/10.7508/iej.2017.02.003
Torres-Palazzolo, C., Ramirez, D., Locatelli, D., Manucha, W., Castro, C., & Camargo, A. (2018). Bioaccessibility and permeability of bioactive compounds in raw and cooked garlic. Journal of Food Composition and Analysis, 70, 49–53. https://doi.org/10.1016/j.jfca.2018.03.008
Ujilestari, T., Danar Dono, N., Ariyadi, B., Martien, R., & Zuprizal, Z. (2018). Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil. Malaysian Journal of Fundamental and Applied Sciences, 14(3), 360–363. https://doi.org/10.11113/mjfas.v14n3.1070
Ujilestari, T., Martien, R., Ariyadi, B., Dono, N. D., & Zuprizal. (2018). Self-nanoemulsifying drug delivery system (SNEDDS) of Amomum compactum essential oil: Design, formulation, and characterization. Journal of Applied Pharmaceutical Science, 8(6), 14–21. https://doi.org/10.7324/JAPS.2018.8603
Untari, I. (2010). Bawang Putih Sebagai Obat Paling Mujarab Bagi Kesehatan. Gaster | Jurnal Ilmu Kesehatan, 7(1), 547–554.
Vemuri, S. K., Banala, R. R., GPV, S., AV, G. R., & Thekkumalai, M. (2018). Apoptotic efficiency of aqueous extracts of turmeric, garlic and their active compounds in combination with Tamoxifen in lung and oral cancers: A comparative study. Beni-Suef University Journal of Basic and Applied Sciences, 7(2), 184–197. https://doi.org/10.1016/j.bjbas.2017.10.006
Vulesevic, B., McNeill, B., Giacco, F., Maeda, K., Blackburn, N. J. R., Brownlee, M., Milne, R. W., & Suuronen, E. J. (2016). Methylglyoxal-induced endothelial cell loss and inflammation contribute to the development of diabetic cardiomyopathy. Diabetes, 65(6), 1699–1713. https://doi.org/10.2337/db15-0568
Wang, Y., Hall, L. M., Kujawa, M., Li, H., Zhang, X., Meara, M. O., Ichinose, X. T., Wang, J., Wang, Y., Lm, H., Kujawa, M., Li, H., Zhang, X., Meara, O. M., Ichinose, T., & Jm, W. (2021). Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K ATP / MAPK pathway. 68–81. https://doi.org/10.1152/ajpcell.00117.2018
Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014). The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators of Inflammation, 2014. https://doi.org/10.1155/2014/561459
Yin, H. F., Yin, C. M., Ouyang, T., Sun, S. D., Chen, W. G., Yang, X. L., He, X., & Zhang, C. F. (2021). Self-nanoemulsifying drug delivery system of genkwanin: A novel approach for anti-colitis-associated colorectal cancer. Drug Design, Development and Therapy, 15, 557–576. https://doi.org/10.2147/DDDT.S292417
Zhang, L., Zhang, L., Zhang, M., Pang, Y., Li, Z., Zhao, A., & Feng, J. (2015). Self-emulsifying drug delivery system and the applications in herbal drugs. Drug Delivery, 22(4), 475–486. https://doi.org/10.3109/10717544.2013.861659
Zhang, M., Pan, H., Xu, Y., Wang, X., Qiu, Z., & Jiang, L. (2017). Allicin decreases lipopolysaccharide-induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2. Cellular Physiology and Biochemistry, 41(6), 2255–2267. https://doi.org/10.1159/000475640
Zhou, Y., Liu, B. L., Liu, K., Tang, N., Huang, J., An, Y., & Li, L. (2008). Establishment of the insulin resistance induced by inflammatory response in 3T3-L1 preadipocytes cell line. Inflammation, 31(5), 355–364. https://doi.org/10.1007/s10753-008-9086-y
Zorzi, G. K., Carvalho, E. L. S., Von Poser, G. L., & Teixeira, H. F. (2015). On the us
Published
2024-05-17
How to Cite
Baroroh, A. R. E., Annisa, Y., Susanto, H., & Lestari, S. R. (2024). EFFECTIVENESS TEST OF SCGE-SNEDDS USED VCO AS CARRIER OIL ON CYTOKINE EXPRESSION IN VITRO. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.4615
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