PENGARUH EKSTRAK KOPI ROBUSTA TERHADAP EKSPRESI OSTEOKALSIN PADA OSTEOBLAS SELAMA PERGERAKAN GIGI ORTODONTI

https://doi.org/10.22146/teknosains.23158

Herniyati Herniyati(1*)

(1) Fakultas Kedokteran Gigi Universitas Jember
(*) Corresponding Author

Abstract


The objective of  research is  to determine the expression of osteocalcin on osteoblasts during orthodontic tooth movement after administration robusta coffee extract. Materials and Methods: 16 rats  were divided into 2 groups: group K: rats applied with orthodontic mechanical force (OMF) and  group P: OMF +  coffee robusta extract of 20mg /100 g of BW. OMF was conducted by applying  ligature wire on permanent maxillary right first molar and both permanent maxillary incisivus. Subsequently, the permanent maxillary right first molar  moved to mesial with Ni-Ti orthodontic closed coil spring. Observations were made on day 15 by immunohistochemical examination to determine the expression of osteocalcin. Results: Robusta coffee extract  improved the expression of osteocalcin in the compression and tension areas (p <0.05). Expression of osteocalcin in  tension area  larger than that in compression area (p <0.05). Conclusion: The administration of Robusta coffee extract  increases the expression of osteocalcin, which can increase alveolar bone remodeling.


Keywords


Alveolar bone remodeling; Orthodontic tooth movement; Osteocalcin; Robusta coffee

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DOI: https://doi.org/10.22146/teknosains.23158

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