Beta defensin polipeptida antimikroba dalam hubungannya dengan periodontitis kronis dan agresif

https://doi.org/10.22146/mkgk.32006

Sugiharto Wijaya(1*), Sri Lelyati C Masulili(2)

(1) Program Pendidikan Dokter Gigi Spesialis Periodonsia, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(2) Departemen Periodonsia, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(*) Corresponding Author

Abstract


Periodontitis merupakan penyakit inflamasi yang menyerang periodonsium dan faktor utama penyebab kehilangan gigi di dunia. Di Indonesia, penyakit periodontal menduduki urutan kedua setelah karies dan masih merupakan masalah di masyarakat. Defensin merupakan elemen kunci dari sistem kekebalan bawaan dan sebagai pertahanan pertama untuk jaringan mulut serta organ lainnya. HBDs telah terdeteksi dalam epitel gingiva, kelenjar ludah, air liur, dan gingival crevicular fluid (GCF). Tujuan telaah pustaka adalah untuk mengetahui tentang adanya peptida antimikroba Human Beta Defensin khususnya Human Beta Defensin-1 dan pengaruhnya terhadap perkembangan terjadinya periodontitis baik kronis maupun agresif. Terdapat peptida antimikroba yang dikenal dengan nama Human Beta Defensin yang merupakan mekanisme pertahanan tubuh awal terhadap infeksi, dimana fungsi dan pengaruhnya masih banyak diperdebatkan oleh para peneliti.

ABSTRACT: Antimicrobial polypeptides beta defensin in conjunction with chronic and aggressive periodontitis. Periodontitis is an inflammatory disease that attacks the periodontium and the main factors causing the loss of teeth in the world. In Indonesia, periodontal disease ranks second after caries and still is a problem in the community. Defensins are key elements of the innate immune system and as a first defense for oral tissues and other organs. HBDs has been detected in the gingival epithelium, salivary glands and saliva and gingival crevicular fluid (GCF). Objective to know about the existence of the Human beta defensin antimicrobial peptides, especially Human beta defensin-1 and its influence on the development of chronic and aggressive periodontitis either. There is an antimicrobial peptide, known as Human beta defensin which is the body's defense mechanism against infection early, in which the function and influence is still much debated by researchers


Keywords


human beta defensin, periodontitis kronis, periodontitis agresif, gingival crevicular fluid, Human beta defensin, chronic periodontitis, aggressive periodontitis, gingival crevicular fluid

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References

1. Berezow AB, Darveau RP. Microbial Shift and Periodontitis. Periodontol. 2000. 2011; 55(1): 36–47.

2. Wahyukundari MA. Perbedaan kadar matriks metalloproteinase-8 setelah skeling dan pemberian tetrasiklin pada penderita periodontitis kronis. PDGI. 2009;

3. Newman M, Takei H, Carranza F. Carranza’s Clinical Periodontology. Novak M, Novak K, editors. St louis, Missouri: Elsevier Mosby; 2012: 160.

4. Fermin A Carranza , Jane L Forrest , E Barrie Kenney et al. Carranza’s Clinical Periodontology. 11th ed. Riverport Lane St. Louis, editor. Missouri: Elsevier Saunders; 2012; 257-70.

5. Phillstrom B, Michakowiz B, Johnson N. Periodontal Diseases. Lancet. 2005; 366: 1809–20.

6. Mahanonda R, N.Sa-Ard-Lam ME. Cigarette smoke extract modulates human B defensin-2 and interleukin-8 expression in human gingival epithelial cells. J Periodont Res. 2009; 44: 557–64.

7. Gaffen SL, Hajishengallis G. A New Inflammatory Cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. J Dent Res. 2008; 87: 817–28.

8. Chung W, Dommisch H, Yin L, Dale B. Expression of Defensins in gingiva and their role in periodontal health and disease. Curr Pharm Des. 2007; 13: 3073–83.

9. Diamond D, Kimbal J, Krisanaprakornkit S, Gantz T, Dale B. Detection of beta-defensins secreted by human oral epithelial cells. J Immunol Methods. 2001; 256: 65–76.

10. Bontanci N, Ilgenli T, Emingil G, Dkk. Gingival Crevicular Fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. J Clin Periodontol. 2007; 34: 370–6.

11. Jochen W, Wenghoefer M. Human Defensins: potential tools for clinical application. Polymers (Basel). 2012; 4: 691–709.

12. Kurland A, Schreiner H, Diamond G. In vivo BD gene expression in rat gingival epithelium in respon to Aggrigattibacter actinomycetemcomitan infection. J Periodont Res. 2006; 41: 567–72.

13. Wohlfuhrt J, Wu T, Hodges J, Hinrich J, Michalowicz B. No association between selected candidate gene polymorphisms and severe chronic periodontitis. J Periodont Res. 2006; 77: 426–36.

14. Aaron W, Ge J, Sieg S. The Yin and Yang of Human Beta Defensins in health and disease. Front Immunol. 2012; 3: 294.

15. Qian L, Lilian J, Richard. Expression of human beta defensin-1 and-2 peptides in unresolved chronic periodontitis. J Periodont Res. 2004; 39: 221–7.

16. Dijk A Van, Veldhuizen, A EJ, Hagsman H. Avian defensins. Elsevier B V. Elsevier B. V; 2008; 124: 1–18.

17. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol. 2008; 79(suppl 8): 1569–76.

18. Kao DWK, Fiorellini JP. Regenerative periodontal therapy. Front Oral Biol. 2012; 15(3): 149–59.

19. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998; 25: 134–44.

20. Vardar S, Demirci T, Sen B. Expression of human beta defensin-1 and -2 expression in the gingiva of patient with spesific periodontal disease. J Periodont Res. 2007; 42: 429–37.

21. Qian L, Samaranayake, Richard P, Darveau RP. Expression of human beta defensin-3 in gingival epithelial. J Periodont Res. 2005; 40: 474–81.

22. Ganz T, Lehrer R. Defensins. pharmacol ther. 1995; 66: 191–205.

23. Matthew M, Jia H, Guthmiller J, Losh G, Graham S, Johnson G. Production of beta defensin anti microbial peptides by the oral mucosa and salivary glands. Infect Immun. 1999; 67: 2740–5.

24. Henrik D. Human beta-defensin(hBD-1, -2) expression in dental pulp. Oral microbiol immunol. 2005; 20(3): 163–6.

25. Ramasundara M, Leach S, Lemberg D. Defensins and Inflamation: The Role of Defensins in Inflamatory Bowel Disease. J gastroenterol hepatol. 2009; 24: 202–8.

26. Garcia J, Krause A, Schulz S. Human beta defensin 4 : a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J. 2001; 15: 1819–21.

27. Jenke A, Zilbauer M, Postberg J, Wirth S. Human beta defensin 2 expression in elbow infant with severe necrotizing enterocolitis. Pediat Res. 2012; 72: 513–20.

28. JA Aas, BJ Paster, LN Stokes, I Olsen FD. Defining the normalbacterial flora of the oral cavity. J Clin Microbiol. 2005; 43: 5721–32.

29. Zhao C, Wang I, Lehrer R. Wide spread expression of beta defensin-1 in human secretory glands and epithelial cells. FEBS Lett. 1996; 396: 319–22.

30. Fiorini T, Vianna P, Weidlich P, Dkk. Relationship between cytokine levels in serum and gingival crevicular fluid (GCF) in pregnant women. Cytokine. 2012; 58(1): 34–9.

31. Pingel L, Kohlgraf K, Hansen C. Human beta defensin-3 bind to hemaglutinin B, a non fimbrial adhesin from Porphyromonas gingivalis and attenuates a proinflamatory cytokine response. Immunol Cell Biol. 2008; 86: 643–9.

32. Marta G, Nora S, Leyla G, Ruben L, Beatric P, Adolfo C, et al. Prevalence of periodontopathic bacteria in Wijaya dan Masulili: Beta defensin polipeptida….. 113 aggressive periodontitis patient in a children population. j periodontol. 2005; 76: 289–94.

33. Puklo M, Guentsch A, Hiemstra P., Eick S, Potempa J. Analysis of neutrophil derived antimicrobial peptides in gingival crevicular fluid suggest importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral microbiol immunol. 2008; 23(4): 328–35.

34. Ganowicz E. Salivary DiagnosticsDiseases of the Oral Cavity. Dent Med Probl. 2011; 48(3): 421–30.

35. Miller CS, Foley JD, Bailey AL, Dkk. Current developments in salivary diagnostics. Biomark Med. 2010; 4: 171–89.

36. ELISA. http://www.bio.davidson.edu/courses/ genomics/method/elisa.html.



DOI: https://doi.org/10.22146/mkgk.32006

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