Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal

Cindy Cahaya; Sri Lelyati C Masulili

doi:10.22146/majkedgiind.8810

Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal

https://doi.org/10.22146/majkedgiind.8810

Cindy Cahaya^(1*), Sri Lelyati C Masulili⁽²⁾

(1) Program Pendidikan Dokter Gigi Spesialis Periodonsia, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(2) Departemen Periodonsia, Fakultas Kedokteran Gigi, Universitas Indonesia, Jakarta, Indonesia
(*) Corresponding Author

Abstract

Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal system that could lead to the destruction of the periodontal tissue and end up with tooth loss. Currently, there are so many researches and efforts to regenerate periodontal tissue, not only to stop the process of the disease but also to reconstruct the periodontal tissue. Periodontal regenerative therapy aims at directing the growth of new bone, cementum and periodontal ligament on the affected teeth. Regenerative procedures consist of soft tissue graft, bone graft, roots biomodification, guided tissue regeneration and combination of the procedures, including restorative surgical procedure that is connected with oral rehabilitation with implant placement. At cellular phase, periodontal regeneration is a complex process with well-organized proliferation, distinction, and development of various type of cell to form attachment of periodontal tissue. Rationalization of the use of guided tissue regeneration as barrier membrane is to prohibit the penetration of epithelial and connective tissue migration into the defect, to maintain space, and to stabilize the clot. This research discusses: 1. Healing process on periodontal therapy including regeneration, repair or formation of new attachment. 2. Periodontal specific tissue engineering. 3. Various commercially available membrane/guided tissue regeneration in the market with its advantages and disadvantages and their characteristics. 4. Recent advancement of membrane as regenerative therapy on periodontal disease. In addition, this review is presented to give an outlook for promising regenerative therapy as a part of developing knowledge and skills to treat periodontal disease.

Keywords

membrane; regeneration; repair and new attachment

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References

Philstrom B, Michalowicz B, Johnson N. Periodontal Diseases. Lancet 2005; 366; 1809.

Nakashima M, Reddi A. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol. 2003; 21: 1025.

Haney J, Nilveus R, McMillan P, Wikesjo U. Periodontal repair in dogs: expanded polytetrafluroethulene barrier support wound stabilization and enhance bone regeneration. J Periodontol. 1993; 64(9): 883–90.

Jung R, Clauser R, Scharer P, Hammerle C, Saeler H, Weber F. Effect or rhBMT-2 0n guided bone regeneration in humans-a randomized, controlled clinical and histomorphometric study. Clin Oral Implants Res. 2003; 14: 556.

Trombelli L. which reconstructive procedures are effective for treating the periodontal intraosseous defect. Periodontol 2000. 2005; 37: 88.

Langer R, Vacanti J. Tissue engineering. Science (8).1993; 260: 920.

Agarwal S, Greiner A, Wendorff J. electrospinning of manmade and biopolymer nanofibers -progress in techniques, materials, and applications. Adv Funct Mater. 2009; 19: 2863.

Yang F, Both S, Yang X, Walboomers X, Jansen J. development of an electrospun nano-apatite/PCL composite membrane for GTR/GBR aplications. Acta Biomater. 2009; 5: 3295.

Bottino MC, Thomas V, Schmidt G, Vohra YK, Chu TG, Kowolik MJ, Janowski GM, Recent advances in the development of GTR/GBR

membranes for periodontal regeneration - A materials perspective. Dent Mater [Internet]. The Academy of Dental Materials; 2012; 28(7): 703-21. Available from:http://dx.doi.org/10.1016/j.dental.2012.04.022

Bottino M, Jose M, Thomas V, Dean D, Janowski G. freeze-dried acellular dermal matrix graft: effects of rehydration on physical, chemical, and mechanical properties. Dent Mater. 2009; 25: 1109.

Kikuchi M, Koyama Y, Yamada T, Imamura Y, Okada T, Shirahama N. development of guided bone regeneration membrane composed of beta-tricalcium phosphate and poly (L-lactide-co-glycolide-epsilon-caprolactone) composites. Biomaterials. 2004; 25: 5979.

Liao S, Wang W, Uo M, Ohkawa S, Akasaka T, Tamura K. A Three layered nano-carbonated hydroxyapatite/collaen/PLGA composite membrane for guided tissue regeneration. Biomaterial. 2005; 23: 7564.

Carranza F, Takei H. Rationale for Periodontal Treatment. Caranza’s Clinical Periodontology, 11th Ed. 2012.p. 387–90.

Taba Jr M, Jin Q, Sugai J GW. Current Concept in Periodontan Bioengineering. Orthod Craniofacial Res. 2005; 8: 292-302.

Newman, Takei, Klokkevold C. Carranza’s Clinical Periodontology. 11’ed ed. St. Louis, Missouri: Elsevier; 2006. 387-390.

Kao R. Periodontal Regeneration and Reconstructive Surgery. In: Rose LF, Mealay BL, Genco RJ, Cohen DW editor. Periodontics:

Medicine,Surgery, and Implants. China: Elsevier Mosby; 2004; 1050.

Sculean A, Nikolidakis D, Schwarz F. regeneration of periodontal tissues: combinations of barrier membranes and grafting materials-biological foundation and preclinical evidence: a systematic review. J Clin Periodontol. 2008; 35: 106.

Zhang Y, Zhang X, Shi B, Miron RJ. Membranes for guided tissue and bone regeneration. 2013; (Table 1): 1–10.

Bathla S. Regenerative Osseous Surgery. Periodontics Revisited. 2011. p. 371–4.

Needleman I, Worthington H, E G-L, Tucker R. Guided tissue regeneration for periodonta infra-bony defects. Cochrane Database Syst Rev. 2006; 29.

Shin S, Park H, Kim K, Lee M, Choi Y, Park Y. biological evaluation of chitosan nanofiber membrane for guided bone regeneration. J Periodontol. 2005; 76: 1778.

Rakhmatia Y, Ayukawa Y, Furuhashi A, Koyano K. Current barrier membranes: Titanium mesh and other membranes for guided bone regeneration in dental application. J Prosthodont Res. 2013; Jan: 57 (1): 3–14.

Jovanovic S, Nevins M. bone formation utilizing titanium-reinforced barrier membranes. Int J Periodontics Restorative Dent. 1995; 15: 56.

Behring J, Junker R, Walboomers X, Chessnut B, Jansen J. Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. a Syst Rev Odontol. 2008; 96: 1.

Millela D, Ramires P, Brescia E, La Sala G. Physiocochemical, mechanical and biologaical properties of commercial membranes for GTR. J Biomed Mater Reseaarch. 2001; 58: 427.

Li J, Zuo Y, Cheng X, Yang W, Wang H, Li Y. preparation and characterization of nanohydroxyapatite/polyamide 66 composite GBR membrane with asymmetric porous structure. J Mater Sci Mater Med. 2009; 20: 1031.

Thoma D, Halg G, Dard M, Seibl R, Hammerle C, Jung R. Evaluation of a new biodegradable membran to prpevent gingival ingrowth into mandibular bone defect in minipigs. Clin oral Implantol Res. 2009; Jan (20)(1): 7–16.

Felipe M, Andrade P, Grisi M, Souza S, Taba M, Palioto D. Comparison of two surgical procedur for use of the acellular dermal matrix graft in the treatment of gingival recession: a randomized controlled clinical study. J Periodontol. 2007; 78: 1209.

Bottino M, Jose M, Thomas V, Dean D, Janowski G. Acellular dermal matrix graft: synergistic effect of rehydration and natural

crosslinking on mechanical properties. J Biomed Mater Res Part B Appl Biomater. 2010; 95: 276.

Gouk S, Lim T, Teoh S, Sun W. Alteration of hman acellular tissue matirx by gamma irradiation: histology biomechanical property, stability, in vitro cell repopulation and remodeling. J Biomed Mater Res Part B Appl Biomater. 2008; 84: 205.

Livesey S, Herndon D, Hollyoak M, Atkinson Y, Nag. A Transplanted acellular allograft dermal matrix-potential as a template for the reconstruction of viable dermis. Transplantation. 1995; 601.

Chen F, LA W, Zhang R, Sun H. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, stategies and translational prerspectives. Biomaterial. 2011; 32: 3189.

Srouji S, Ben-David D, Lotan R, Livne E, Avrahami R. Slow-release human recombinant bone morphogenic protein-2 embedded

withing electrospun scaffolds for regeneratiion of bone defect: in vitro and in vivo evaluation. Tissue Eng Part A. 2011; 17: 269.

Bottino M, Thomas V, Janowski G. A novel spatially designed and functionally graded elecstropun membrane for periodontal

regeneraion. Acta Biomater. 2011; 7: 216.

Li W, Laurencin C, Caterson E, Tuan R, Ko F. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 2002; 60: 613.

Li, Cooper J, Mauck R, Tuan R. Fabrication and characterization of six electrospun poly(alphahydroxy ester)-based fibrous scaffolds for tissue engineering application. Acta Biomater. 2006; 2: 377.

Thomas V, Zhang X, Cetledge S, Vohra Y. Functionally graded electrospun scaffolds with tunable mechanical properties for vascular tissue regeneration. Biomed Mater. 2007; 2: 224.

Al-Mubarak S, Karring TAH. Clinical evaluation of subgingival applicationn of metronidazole 25% and adjuctive therapy. J Int Acad Periondotology. 2000; 2: 64.

Karsenty G. The genetic transformation of bone biology. Gene Dev. 1999; 13: 3037.

El-Ghannam. A bone reconstruction from bioceramics to tissue engineering. Expert Rev Med Devices. 2005; 57: 87.

Chou A, LeGeros R, Chen Z, Li Y. Antibacterial effect of zinc phosphate mineralized guided bone regeneration membranes. Implant Dent. 2007; 16: 89.

Chen F, Zhang J, Zhang M, An Y, Chen F, Wu Z. A review of endogenous regenerative technology in perodontal regenerative

medicine. Biomaterials. 2010; 31: 7892.

Rathe F, Junker R, Chesnutt B, Jansen J. The effect of enamel matrix derivative (Emdogain) on bone formation: a systematic review. Tissue engineering Part B:Reviews. 2009; 15: 215.

Thoma D, Villar C, Carnes D, Dard M, Chun Y, Cochran D. Angiogenic activity of an enamel matrix derivative (EMD) and EMD-derived protein: an experiment study in mice. J Clin Periodontol. 2011; 38: 253.

Granding H, Gemperli A, Dard M. Enamel matrid derivative: a review of cellular effect in vitro and a model of molecular arrangement and functioning. Tissue engineering Part B: 2011; December.

Fisher O, Khademhosseini A, Langer R, Peppas N. Bioinspired material for controlling stem cell fate. Acc Chem Res. 2010; 43: 419.

Lin C, Anseth K. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res. 2009; 26: 631.

DOI: https://doi.org/10.22146/majkedgiind.8810