CHA-collagen implantation to increase alveolar bone density

https://doi.org/10.22146/majkedgiind.41142

Dody Setiawan(1*), Poerwati Soetji Rahajoe(2), Cahya Yustisia Hasan(3)

(1) Rokan Hulu Hospital, Riau Oral and Maxillofacial Surgery Specialty Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta,
(2) Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(3) Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Tooth extraction is the common procedure in dentistry. This procedure causes a wound in teeth socket. Thus, the socket had to be secured to prevent over resorption of alveolar bone. This study used the third molar as a model to examine the third molar mandibular odontectomy routine procedure in oral and maxillofacial surgery. The new bone formation could be evaluated by radiographic examination. The aim of this study was to evaluate the effect of CHA-collagen implantation on the third molar mandibular bone density using 3D-CBCT to determine bone quality. The research was conducted by comparing extraction socket after the third molar mandible odontectomy, before and after graft material implantation. The subjects were divided into two groups. Group A consisted of six non-implanted subjects and group B consisted of six subjects with CHA-collagen implanted socket. Three dimensional CBCT evaluated alveolar bone density using pixel intensity at the socket area after odontectomy procedure and 10 weeks after. The result of t-test showed that CHAcollagen implanted socket had significantly higher pixel intensity than non-implanted group (p=0,046) until 10 weeks. Spearman test showed that the implanted CHA-collagen had a positive correlation with the increase of alveolar bone density (p=0.028; r=0.860) until 10 weeks. In brief, implantation of CHA-collagen increased bone density until 10 weeks.

Keywords


alveolar bone density; carbonate hydroxyapatite-collagen; 3D-CBCT

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References

1. Fragiskos FD. Oral Surgery 2nd ed. Springer-Verlag.Berlin. 2012;121-140.

2. Kubilius M, Kubilius R, Gleiznys A. The preservation of alveolar bone ridge during tooth extraction. Stomatologija. 2012; 14(1): 3-11.

3. Bartee B. Extraction site reconstruction for alveolar ridge preservation. Part 2: membraneassisted surgical technique. J Oral Implantol. 2001; 27(4): 194-197.
doi: 10.1563/1548-1336(2001)027<0194:ESRFAR>2.3.CO;2

4. American Association of Oral and Maxilofacial Surgeons. Bone Grafting After Removal of Impacted Third Molars 1sted, New York. 2013; 1-2.

5. Ana ID, Erwanto Y. Evaluation of osteoconductive capacity of bio-inspired
carbonate apatite bone subtitute in goat model. Proceeding Book: International Symposium on Apatite and Correlative Biomaterials IV. Nantes. 2013; 1-8.

6. Ana ID. Modul pengenalan singkat Gama-CHA your bone regeneration scalffold. Yogyakarta: UGM Press. 2014; 1-21.

7. Alamri HM, Sadrameli M, Alshalhoob MA, Sadrameli M, Alshehri MA. Applications of CBCT in dental practice: a review of the literature. Gen Dent. 2012; 60(5): 390-400.

8. Scarf WC, Farman AG. What is cone-beam CT and how does it work? Dent Clin N Am. 2008; 52(4): 707-730. doi: 10.1016/j.cden.2008.05.005

9. Bankhead P. Analyzing fluorescence microscopy images with ImageJ. Queens
University Belfast, http://image.nih.gov/ij/images/. 2014; 12-28.

10. Labno C. Basic Intensity Quantification with ImageJ. University of Chicago; 2015. 1-5.

11. Burr DB, Allen MR. Basic and Applied Bone Biology, 1sted. New York: Elsevier; 2014; 1-48.

12. Lutfianto B, Rahardjo, Rahajoe PS. Ekspresi mRNA osteokalsin pada soket pasca pencabutan gigi dengan pemberian bahan cangkok tulang carbonate-hydroxyapatite (Studi Eksperimental pada Manusia). J Ked Gi. 2017; 8(3): 280-286.

13. Nandi SK, Roy S, Mukherjee P, Kundu B, De DK, Basu D. Orthopaedic applications of bone graft and graft substitutes: a review. Indian J Med Res. 2010; 132: 15-30.

14. Ana ID, Matsuya S, Ishikawa K. Engineering of carbonate apatite bone substitute based on composition-transformation of gypsum and calcium hydroxide. Engineering. 2010; 2(5): 344-352. doi: 10.4236/eng.2010.25045

15. Panday V, Upadhyaya V, Berwal V, Jain K, Sah N, Sarathi P, Swami PC. Comparative evaluation of G-Bone (Hydroxyapatite) dan G-Graft (Hydroxyapatite with Collagen) as bone graft material in mandibular III Molar Extraction Socket. J Clin Diagn Res. 2015; 9(3): 48-52. doi: 10.7860/JCDR/2015/12140.5713

16. Madan R, Gupta V, Bains VK, Patil SS, Singh GP, Madan M. Socket preservation vis-a-vis natural healing: literatur review. Asian Journal of Health & Allied Sciences. 2011; 1(3): 195-201.

17. Oscandar F. Radiologi Kedokteran Gigi Aplikasi 3D-CBCT 1sted. Jakarta: EGC. 2013; 43-54.

18. Vohra A. Radiological measurement of bone density to assess the efficiency of bone graft. IAIM. 2016; 3(2): 88-91.

19. Haghighat A, Hekmatian E, Abdinian M, Sadeghkhani E. Radiographic evaluation of bone formation and density changes after after mandibular third molar extraction: a 6 month follow up. Dent Res J (Isfahan). 2011; 8(1): 1-5.

20. Ferreira T, Rasband W. ImageJ User Guide: ImageJ/Fiji; 2012. 1-46, 149-154, http://imagej.nih.gov/ij/features.html.

21. Baecker V. Workshop: Image Processing and Analysis with ImageJ and MRI Cell Image Analyzer. Montpellier RIO Imaging; 2008. 7-8.



DOI: https://doi.org/10.22146/majkedgiind.41142

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