The effect of platelet-rich fibrin on the acceleration of osteoblast proliferation after endosseous dental implant insertion
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Evan Chandra(1), Suparyono Saleh(2), Murti Indrastuti(3*)
(1) Dr. Moewardi Hospital Surakarta, Central Java Prosthodontics Specialty Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(2) Department of Prosthodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(3) Department of Prostodonsia, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
(*) Corresponding Author
Abstract
control groups, dental implants were immediately inserted after implant bed preparation without PRF administration. Observation of the Wistar rats was carried out on days 14 and 28 for each group. The rats were terminated according
to the timeline of group design. The epicondylus lateralis femoris dextra bone of the rats was taken and fixed with 10% buffered formalin solution. Then, histological samples were made with hematoxylin-eosin staining. Sample observation was done under a light microscope to calculate the number of osteoblasts. The data were analyzed using the two-way ANOVA test, followed by LSD post hoc test. Based on the two-way ANOVA test, there was a significant difference between control groups and treatment groups (p<0.05), and there were significant differences between the observation result of days 14 and 28 (p<0.05). The application of PRF increased osteoblast proliferation for the first 14 days, but the rate decreased after that. Based on the LSD post hoc test, there were differences in osteoblast proliferation between the treatment and control group (p<0.05). Thus, it is concluded that platelet-rich fibrin increased the acceleration of
osteoblast proliferation after endosseous dental implant insertion.
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