The effect of bitter gourd (Momordica charantia) ethanolic extract on inflammatory infiltrates and NF-κB activation in periodontitis
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Aryudhi Armis(1*), Tetiana Haniastuti(2), Heni Susilowati(3)
(1) Dental Nursing Study Program, Health Polytechnic of the Ministry of Health of Tanjung Karang, Lampung Master of Dental Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(2) Department of Oral Biology, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(3) Department of Oral Biology, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
analysis was performed to observe cells that were positive for NF-κB activation. The results showed a decrease in the density of inflammatory infiltrates in all groups, except for those given aquades. The number of inflammatory cells of
neutrophils, macrophages, and lymphocytes that experienced NF-κB activation showed the most effective decrease in the group of Momordica charantia 500 mg/kg BW, on the 7th day. The conclusion of this study is that ethanolic extract
of Momordica charantia has an anti-inflammatory effect and prevents the activation of NF-kB in rat gingival induced by periodontitis. The highest effect was found at a dose of 500 mg/kg BW on day 7 after giving of extracts.
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