Pola Peresepan Obat Antihipertensi Pada Pasien Geriatri

Yuli Edy Saputra(1), Purwantiningsih Purwantiningsih(2*), Agung Endro Nugroho(3)
(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada Yogyakarta
(2) Depertemen Farmakologi & Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(3) Depertemen Farmakologi & Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Salah satu penyakit degeneratif yang paling sering diderita pada pasien geriatri yaitu hipertensi. Hipertensi dikenal dengan meningkatnya tekanan darah yang melebihi batas normal yaitu 140 mmHg untuk tekanan darah sistolik dan 90 mmHg untuk tekanan darah diastolik. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana gambaran pola peresepan obat antihipertensi pada pasien geriatri. Penelitian ini bersifat observasi/deskriptif dengan pengambilan data retrospektif. Data diambil dari catatan rekam medik pada pasien geriatri. Kriteria inklusi yang digunakan yaitu pasien geriatri dengan diagnosis hipertensi primer (I10 Esseential [Primary] Hypertension) yang dirawat inap di RSUP Dr. Sardjito. Hasil penelitian dari 98 pasien, 45,9% diberi resep monoterapi, 35,7%menggunakan dua kombinasi obat antihipertensi, 11,2% diberi tiga kombinasi obat antihipertensi, dan 7,1% diberi empat kombinasi obat. Pada penelitian ini yang paling banyak diresepkan pada pasien geriatri rawat inap RSUP Dr. Sardjito yaitu amlodipin sebesar 27,55%. Calcium channel blocker khususnya amlodipin merupakan obat antihipertensi yang paling sering digunakan, dan ditemukan pada pasien geriatric dianggap efektif dan dapat ditoleransi dengan baik.
Keywords
Full Text:
PDFReferences
Abel, N., Contino, K., Jain, N., Grewal, N., Grand, E., Hagans, I., Hunter, K., & Roy, S. (2015). Eighth Joint National Committee (JNC-8) Guidelines and the Outpatient Management of Hypertension in the African-American Population. North American Journal of Medical Sciences, 7(10), 438–445. https://doi.org/10.4103/1947-2714.168669
Aronow, W. S., Fleg, J. L., Pepine, C. J., Artinian, N. T., Bakris, G., Brown, A. S., Ferdinand, K. C., Ann Forciea, M., Frishman, W. H., Jaigobin, C., Kostis, J. B., Mancia, G., Oparil, S., Ortiz, E., Reisin, E., Rich, M. W., Schocken, D. D., Weber, M. A., & Wesley, D. J. (2011). ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly. Journal of the American College of Cardiology, 57(20), 2037–2114. https://doi.org/10.1016/j.jacc.2011.01.008
Bai, X., Han, B., Zhang, M., Liu, J., Cui, Y., & Jiang, H. (2023). The association between diuretics and falls in older adults: A systematic review and meta-analysis. Geriatric Nursing, 52, 106–114. https://doi.org/10.1016/j.gerinurse.2023.05.009
Borghi, C., & Tartagni, E. (2012). The older patient with hypertension: Care and cure. Therapeutic Advances in Chronic Disease, 3(5), 231–236. https://doi.org/10.1177/2040622312452189
Healey, J. S., Baranchuk, A., Crystal, E., Morillo, C. A., Garfinkle, M., Yusuf, S., & Connolly, S. J. (2005). Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: A meta-analysis. Journal of the American College of Cardiology, 45(11), 1832–1839. https://doi.org/10.1016/j.jacc.2004.11.070
Israili, Z. H., & Hall, W. D. (1995). ACE inhibitors. Differential use in elderly patients with hypertension. Drugs & Aging, 7(5), 355–371. https://doi.org/10.2165/00002512-199507050-00004
Kementrian Kesehatan RI. (2018). Laporan Nasional RISKESDAS 2018.
Li, E. C., Heran, B. S., & Wright, J. M. (2014). Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. Cochrane Database of Systematic Reviews, 2014(8). https://doi.org/10.1002/14651858.CD009096.pub2
Lim, K., Sivasampu, S., & Khoo, E. (2015). Antihypertensive drugs for elderly patients: A cross‑sectional study. Singapore Medical Journal, 56(05), 291–297. https://doi.org/10.11622/smedj.2015019
Lukito, A. A., & Harmeiwaty, E. (2019). Perhimpunan Dokter Hipertensi Indonesia.
Ma, C., Cao, J., Lu, X.-C., Guo, X.-H., Gao, Y., Liu, X.-F., & Fan, L. (2012). Cardiovascular and cerebrovascular outcomes in elderly hypertensive patients treated with either ARB or ACEI. Journal of Geriatric Cardiology : JGC, 9(3), 252–257. https://doi.org/10.3724/SP.J.1263.2011.12031
Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., Galderisi, M., Grobbee, D. E., Jaarsma, T., Kirchhof, P., Kjeldsen, S. E., Laurent, S., Manolis, A. J., Nilsson, P. M., Ruilope, L. M., … Wood, D. A. (2013). 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal, 34(28), 2159–2219. https://doi.org/10.1093/eurheartj/eht151
Mazza, A., Ramazzina, E., Cuppini, S., Armigliato, M., Schiavon, L., Rossetti, C., Marzolo, M., Santoro, G., Ravenni, R., Zuin, M., Zorzan, S., Rubello, D., & Casiglia, E. (2012). Antihypertensive Treatment in the Elderly and Very Elderly: Always “the Lower, the Better?” International Journal of Hypertension, 2012, 590683. https://doi.org/10.1155/2012/590683
Myers, M. G. (1986). Diuretic therapy for hypertension in the elderly. Drugs, 31 Suppl 4, 184–191. https://doi.org/10.2165/00003495-198600314-00022
Okoye, C., Mazzarone, T., Cargiolli, C., & Guarino, D. (2023). Discontinuation of Loop Diuretics in Older Patients with Chronic Stable Heart Failure: A Narrative Review. Drugs & Aging, 40(11), 981–990. https://doi.org/10.1007/s40266-023-01061-1
Peterson, S., & Bredow, T. S. (2020). Middle Range Theories: Application to Nursing Research and Practice (5th edition). LWW.
Spiering, W., Burnier, M., Clement, D. L., Coca, A., de Simone, Dominiczak, A., Kahan, T., Mahfoud, F., Redon, J., Ruilope, L., Zanchetti, A., Kerins, M., Kjeldsen, E., Kreutz, R., Laurent, S., Lip, G. Y. H., McManus, R., Narkiewicz, K., Ruschitzka, F., … Desormais, I. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension. Journal of Hypertension, 36(10).
Suzuki, T., Isselbacher, E. M., Nienaber, C. A., Pyeritz, R. E., Eagle, K. A., Tsai, T. T., Cooper, J. V., Januzzi, J. L., Braverman, A. C., Montgomery, D. G., Fattori, R., Pape, L., Harris, K. M., Booher, A., Oh, J. K., Peterson, M., Ramanath, V. S., Froehlich, J. B., & IRAD Investigators. (2012). Type-selective benefits of medications in treatment of acute aortic dissection (from the International Registry of Acute Aortic Dissection [IRAD]). The American Journal of Cardiology, 109(1), 122–127. https://doi.org/10.1016/j.amjcard.2011.08.012
Thomas, G. N., Chan, P., & Tomlinson, B. (2006). The role of angiotensin II type 1 receptor antagonists in elderly patients with hypertension. Drugs & Aging, 23(2), 131–155. https://doi.org/10.2165/00002512-200623020-00004
Wehling, M. (2013). Morbus Diureticus in the Elderly: Epidemic Overuse of a Widely Applied Group of Drugs. Journal of the American Medical Directors Association, 14(6), 437–442. https://doi.org/10.1016/j.jamda.2013.02.002
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., MacLaughlin, E. J., Muntner, P., Ovbiagele, B., Smith, S. C., Spencer, C. C., Stafford, R. S., Taler, S. J., Thomas, R. J., Williams, K. A., … Wright, J. T. (2018). 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension (Dallas, Tex.: 1979), 71(6), 1269–1324. https://doi.org/10.1161/HYP.0000000000000066

Article Metrics


Refbacks
- There are currently no refbacks.