Modifikasi Metode Pemberian Infus Vankomisin dan Amiodaron Melalui Vena Perifer : Kajian Literatur

Ilmi Nur Hafizah; Ika Puspitasari; Tri Murti Andayani

doi:10.22146/farmaseutik.v21i1.94376

Modifikasi Metode Pemberian Infus Vankomisin dan Amiodaron Melalui Vena Perifer : Kajian Literatur

https://doi.org/10.22146/farmaseutik.v21i1.94376

Ilmi Nur Hafizah⁽¹⁾, Ika Puspitasari^(2*), Tri Murti Andayani⁽³⁾

(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(2) Fakultas Farmasi, Universitas Gadjah Mada
(3) Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Amiodaron dan vankomisin merupakan obat yang sering digunakan pada populasi bedah jantung dengan saran pemberiannya melaui vena sentral. Akan tetapi, pemasangan vena sentral menimbulkan berbagai komplikasi yang dapat memperburuk kondisi pasien, serta penggunaannya secara teknis susah untuk diterapkan pada kondisi darurat. Sehingga diperlukan cara/metode pemberian infus melalui vena perifer dengan memperhatikan reaksi yang ditimbulkan seperti infiltrasi, ekstravasasi, plebitis bahkan infeksi. Kajian ini bertujuan untuk mengetahui apakah modifikasi metode atau pedoman praktek klinik pemberian infus amiodaron atau vankomisin melalui perifer aman dan dapat menurunkan komplikasi. Pencarian literatur dilakukan menggunakan database Pubmed dan Cochrane yang diterbitkan 10 tahun terakhir yang berupa penelitian observasional maupun experimental dengan desain penelitian cohort, crossectional, deskriptif, randomized control trial dan quasi experimental. Dari 26 artikel yang ditemukan terdapat 4 artikel yang memenuhi kriteria peneliti. Kesimpulan dari hasil penelusuran yang didapat yaitu pemberian infus vankomisin dalam jangka waktu pendek aman diberikan melalui vena perifer khususnya menggunakan kateter midline dan penggunaan konsentrasi vankomisin yang rendah mampu menurunkan kejadian plebitis. Sedangkan Pemberian amiodaron konsentrasi tinggi disarankan menggunakan vena sentral disertai penggunaan in-line filter.

Keywords

Vankomisin; Amiodaron; Infus; Vena Perifer

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DOI: https://doi.org/10.22146/farmaseutik.v21i1.94376