Identifikasi Faktor yang Mempengaruhi, Mikroorganisme, dan Sensitivitas Antibiotik Pada Pasien Ulkus Kaki Diabetik : Kajian Literatur

https://doi.org/10.22146/farmaseutik.v21i2.94342

Rizka Maulidiah(1), Nanang Munif Yasin(2*), Titik Nuryastuti(3)

(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta
(2) Faculty of Pharmacy UGM
(3) Departemen Mikrobiologi, Fakultas Kedokteran, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Komplikasi yang dapat terjadi pada pasien diabetes yaitu adanya ulkus yang berisiko terjadi infeksi yang dapat berkibat gangguan neurologis dan pembuluh darah perifer pada bagian ekstremitas bawah. Ulkus ditandai dengan terjadinya kerusakan kulit yang disertai dengan menghilangnya epitel yang bisa meluas hingga dermis dan lapisan yang lebih dalam. Penulisan artikel ini bertujuan melihat faktor yang mempengaruhi, mikroorganisme, dan sensitivitas antibiotik pasien ulkus diabetikum.  Penelitian ini dilakukan dengan metode PRISMA dengan mencari data pada database seperti Scopus. Hasil yang didapatkan dari review yaitu faktor yang dapat mempengaruhi komplikasi ulkus diabetik diantaranya yaitu usia, jenis ulkus, kedalaman dan derajat ulkus, kekambuhan, tingkat obesitas, BMI, penggunaan antibiotik yang tidak tepat, dan osteomielitis mempunyai hubungan dengan infeksi MDR pada pasien infeksi kaki diabetik bakteri gram negatif yang sering ditemukan yaitu Pseudomonas aeruginosa, Klebsiella penumonia, Proteus mirabillis, dan Escherichia coli. Sedangkan bakteri gram positif yang sering ditemukan yaitu Staphylococcus aureus dan Enterococcus faecalis. Bakteri gram negatif mempunyai sensitivitas yang baik terhadap amikasin, sedangkan vancomysin, teicoplanin, dan tigecycline mempunyai sensitivitas yang baik pada bakteri gram positif.

Keywords


antibiotik, ulkus diabetikum, sensitivitas, faktor yang mempengaruhi

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References

Alsabek, M. B., & Abdul Aziz, A. R. (2022). Diabetic foot ulcer, the effect of resource‐poor environments on healing time and direct cost: A cohort study during Syrian crisis. International Wound Journal, 19(3), 531–537. https://doi.org/10.1111/iwj.13651

Anggraini, D., Yovi, I., Yefri, R., Christianto, E., & Syahputri, E. Z. (2020). Pola Bakteri Dan Antibiogram Penyebab Ulkus Diabetikum Di RS X Riau Periode 2015—2018. Biomedika, 12(1), 27–35. https://doi.org/10.23917/biomedika.v12i1.9316

Anita, H., Manoj, A., Arunagirinathan, N., Rameshkumar, M. R., Revathi, K., Selvam, R., Kannan, T., Darwish, N. M., Al Farraj, D. A., & AbdelGawwad, M. R. (2023). Bacterial etiology, antibiotic resistance profile and foot ulcer associated amputations in individuals with Type II diabetes mellitus. Journal of King Saud University - Science, 35(8), 102891. https://doi.org/10.1016/j.jksus.2023.102891

Carro, G. V., Saurral, R., Salvador Sagüez, F., & Witman, E. L. (2022). Diabetic Foot Infections: Bacterial Isolates From the Centers and Hospitals of Latin American Countries. The International Journal of Lower Extremity Wounds, 21(4), 562–573. https://doi.org/10.1177/1534734620976305

Chu, Y., Wang, C., Zhang, J., Wang, P., Xu, J., Ding, M., Li, X., Hou, X., Feng, S., & Li, X. (2015). Can We Stop Antibiotic Therapy When Signs and Symptoms Have Resolved in Diabetic Foot Infection Patients? The International Journal of Lower Extremity Wounds, 14(3), 277–283. https://doi.org/10.1177/1534734615596891

Dawaiwala, I., Awaghade, S., Kolhatkar, P., Pawar, S., & Barsode, S. (2023). Microbiological Pattern, Antimicrobial Resistance and Prevalence of MDR/XDR Organisms in Patients With Diabetic Foot Infection in an Indian Tertiary Care Hospital. The International Journal of Lower Extremity Wounds, 22(4), 695–703. https://doi.org/10.1177/15347346211038090

Dubský, M., Jirkovská, A., Bem, R., Fejfarová, V., Skibová, J., Schaper, N. C., & Lipsky, B. A. (2013). Risk factors for recurrence of diabetic foot ulcers: Prospective follow-up analysis in the Eurodiale subgroup. International Wound Journal, 10(5), 555–561. https://doi.org/10.1111/j.1742-481X.2012.01022.x

Ghobadi, A., Ahmadi Sarbarzeh, P., Jalilian, M., Abdi, A., & Manouchehri, S. (2020). Evaluation of Factors Affecting the Severity of Diabetic Foot Ulcer in Patients with Diabetes Referred to a Diabetes Centre in Kermanshah. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 13, 693–703. https://doi.org/10.2147/DMSO.S242431

Goh, T. C., Bajuri, M. Y., C. Nadarajah, S., Abdul Rashid, A. H., Baharuddin, S., & Zamri, K. S. (2020). Clinical and bacteriological profile of diabetic foot infections in a tertiary care. Journal of Foot and Ankle Research, 13(1), 36. https://doi.org/10.1186/s13047-020-00406-y

Jain, S., & Barman, R. (2017). Bacteriological profile of diabetic foot ulcer with special reference to drug-resistant strains in a tertiary care center in North-East India. Indian Journal of Endocrinology and Metabolism, 21(5), 688. https://doi.org/10.4103/ijem.IJEM_546_16

Khan, M. S., Azam, M., Khan, M. N., Syed, F., Ali, S. H. B., Malik, T. A., Alnasser, S. M. A., Ahmad, A., Karimulla, S., & Qamar, R. (2023). Identification of contributing factors, microorganisms and antimicrobial resistance involved in the complication of diabetic foot ulcer treatment. Microbial Pathogenesis, 184, 106363. https://doi.org/10.1016/j.micpath.2023.106363

Li, X., Du, Z., Tang, Z., Wen, Q., Cheng, Q., & Cui, Y. (2022). Distribution and drug sensitivity of pathogenic bacteria in diabetic foot ulcer patients with necrotizing fasciitis at a diabetic foot center in China. BMC Infectious Diseases, 22(1), 396. https://doi.org/10.1186/s12879-022-07382-7

Lim, J. Z. M., Ng, N. S. L., & Thomas, C. (2017). Prevention and treatment of diabetic foot ulcers. Journal of the Royal Society of Medicine, 110(3), 104–109. https://doi.org/10.1177/0141076816688346

Lipsky, B. A. (2016). Diabetic foot infections: Current treatment and delaying the ‘post-antibiotic era.’ Diabetes/Metabolism Research and Reviews, 32(S1), 246–253. https://doi.org/10.1002/dmrr.2739

Lipsky, B. A., Berendt, A. R., Cornia, P. B., Pile, J. C., Peters, E. J. G., Armstrong, D. G., Deery, H. G., Embil, J. M., Joseph, W. S., Karchmer, A. W., Pinzur, M. S., & Senneville, E. (2012). 2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infectionsa. Clinical Infectious Diseases, 54(12), e132–e173. https://doi.org/10.1093/cid/cis346

Ma, L.-L., Li, B.-X., Meng, X., & Li, M.-C. (2022). Clinical and microbiological profile of bacterial pathogens from patients with diabetic foot infections at a teaching hospital in the northeast China. European Journal of Inflammation, 20, 1721727X2211278. https://doi.org/10.1177/1721727X221127874

McGregor, J. C., Rich, S. E., Harris, A. D., Perencevich, E. N., Osih, R., Lodise, T. P., Miller, R. R., & Furuno, J. P. (2007). A Systematic Review of the Methods Used to Assess the Association between Appropriate Antibiotic Therapy and Mortality in Bacteremic Patients. Clinical Infectious Diseases, 45(3), 329–337. https://doi.org/10.1086/519283

Murali, T. S., Kavitha, S., Spoorthi, J., Bhat, D. V., Prasad, A. S. B., Upton, Z., Ramachandra, L., Acharya, R. V., & Satyamoorthy, K. (2014). Characteristics of microbial drug resistance and its correlates in chronic diabetic foot ulcer infections. Journal of Medical Microbiology, 63(10), 1377–1385. https://doi.org/10.1099/jmm.0.076034-0

Neves, J. M., Duarte, B., Pinto, M., Formiga, A., & Neves, J. (2019). Diabetic Foot Infection: Causative Pathogens and Empiric Antibiotherapy Considerations—The Experience of a Tertiary Center. The International Journal of Lower Extremity Wounds, 18(2), 122–128. https://doi.org/10.1177/1534734619839815

Perim, M. C., Borges, J. D. C., Celeste, S. R. C., Orsolin, E. D. F., Mendes, R. R., Mendes, G. O., Ferreira, R. L., Carreiro, S. C., & Pranchevicius, M. C. D. S. (2015). Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections. Revista Da Sociedade Brasileira de Medicina Tropical, 48(5), 546–554. https://doi.org/10.1590/0037-8682-0146-2015

Permana, H., Saboe, A., Soetedjo, N. N., Kartika, D., & Alisjahbana, B. (2022). Empirical Antibiotic for Diabetic Foot Infection in Indonesian Tertiary Hospital, Is It Time to Rethink the Options? Acta Med Indones, 54(2).

Rizqiyah, H., Soleha, T. U., Hanriko, R., & Apriliana, E. (2020). Pola Bakteri Ulkus Diabetikum Pada Penderita Diabetes Melitus di RSUD Dr. H. Abdul Moeloek. Majority, 9(2), 128–135.

Schaper, N. C., Netten, J. J. V., Apelqvist, J., Bus, S. A., Hinchliffe, & Lipsky, B. A. (2019). IWGDF Practical Guidelines on The Prevention and Management of Diabetic Foot Disease. The International Working Group on the Diabetic Foot.

Wasnik, R. N., Marupuru, S., Mohammed, Z. A., Rodrigues, G. S., & Miraj, S. S. (2019). Evaluation of antimicrobial therapy and patient adherence in diabetic foot infections. Clinical Epidemiology and Global Health, 7(3), 283–287. https://doi.org/10.1016/j.cegh.2018.10.005

Wu, W., Liu, D., Wang, Y., Wang, C., Yang, C., Liu, X., Mai, L., Ren, M., & Yan, L. (2017). Empirical Antibiotic Treatment in Diabetic Foot Infection: A Study Focusing on the Culture and Antibiotic Sensitivity in a Population From Southern China. The International Journal of Lower Extremity Wounds, 16(3), 173–182. https://doi.org/10.1177/1534734617725410

Zhang, P., Lu, J., Jing, Y., Tang, S., Zhu, D., & Bi, Y. (2017). Global epidemiology of diabetic foot ulceration: A systematic review and meta-analysis. Annals of Medicine, 49(2), 106–116. https://doi.org/10.1080/07853890.2016.1231932



DOI: https://doi.org/10.22146/farmaseutik.v21i2.94342

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