Narrative Review: Keberhasilan Terapi Proton Pump Inhibitor (PPI) Pada Gastroesophageal Reflux Disease (GERD)

Retno Amalia; Agung Endro Nugroho; Probosuseno Probosuseno

doi:10.22146/farmaseutik.v20i4.93163

Narrative Review: Keberhasilan Terapi Proton Pump Inhibitor (PPI) Pada Gastroesophageal Reflux Disease (GERD)

https://doi.org/10.22146/farmaseutik.v20i4.93163

Retno Amalia⁽¹⁾, Agung Endro Nugroho^(2*), Probosuseno Probosuseno⁽³⁾

(1) Mahasiswa Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(2) Fakultas Farmasi, Universitas Gadjah Mada
(3) Departemen Ilmu Penyakit Dalam, Divisi Geriatri, Fakultas Kedokteran Kesehatan
(*) Corresponding Author

Abstract

Gastroesophageal Reflux Disease (GERD) pada lazimnya disangka seperti penyakit yang ringan, namun mampu menimbulkan kekambuhan dan kematian bila tidak diatasi dengan benar. Tingkat kekambuhan terapi pada pasien GERD diperkirakan bahwa 10% sampai 40% dari pasien GERD. Studi berikut berupa narrative review dengan mengunakan pustaka acuan yang mengacu pada pangkalan data Cochrane, PubMed, dan Science Direct. Penggalian pustaka acuan memakai kata kunci GERD, PPI, keberhasilan terapi GERD. Proton Pump Inhibitor (PPI) merupakan terapi yang sangat besar pengaruhnya akan memulihkan GERD, jika dipadankan terhadap antasida, prokinetik, dan H2 bloker receptor. Proton Pump Inhibitor (PPI) telah merevolusi penatalaksanaan pasien GERD karena efek penekanan asam yang mendalam dan berkepanjangan sehingga menjadi terapi andalan, bila dibandingkan dengan obat penekan asam lainnya, PPI menunjukkan penyembuhan mukosa dan pengendalian gejala yang lebih baik. serta mencegah mukosa dan gejala kambuh.

Keywords

GERD; PPI; keberhasilan terapi GERD

Full Text:

PDF

References

Abdallah, J., George, N., Yamasaki, T., Ganocy, S., dan Fass, R., 2019. Most Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Also Have Functional Esophageal Disorders. Clinical Gastroenterology and Hepatology, 17: 1073-1080.e1.

Aisiyah, N., Yuswar, M.A., dan Purwanti, N.U., 2022. Rasionalitas Penggunaan Obat Pada Pasien GERD di Instalasi Rawat Jalan Rumah Sakit. Journal Syifa Sciences and Clinical Research (JSSCR), 4 Nomor 3: .

Cho, J.H., Shin, C.M., Yoon, H., Park, Y.S., Kim, N., dan Lee, D.H., 2020. Efficacy of a high-dose proton pump inhibitor in patients with gastroesophageal reflux disease: a single center, randomized, open-label trial. BMC Gastroenterology, 20: 275.

Domingues, G. dan Moraes-Filho, J.P.P., 2014. Noncompliance is an impact factor in the treatment of gastroesophageal reflux disease. Expert Review of Gastroenterology & Hepatology, 8: 761–765.

Erridge, S., Moussa, O.M., Ziprin, P., Darzi, A., dan Purkayastha, S., 2018. Risk of GERD-Related Disorders in Obese Patients on PPI Therapy: a Population Analysis. Obesity Surgery, 28: 2796–2803.

Fugit, Randolph V dan Berardi, Rosemary R, 2013. Applied Therapeutics: The Clinical Use of Drugs, 10th ed. ed. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia.

Goh, K.L., Choi, K.D., Choi, M.-G., Hsieh, T.-Y., Jung, H.-Y., Lien, H.-C., dkk., 2014. Factors influencing treatment outcome in patients with gastroesophageal reflux disease: outcome of a prospective pragmatic trial in Asian patients. BMC Gastroenterology, 14: 156.

Hillman, L., Yadlapati, R., Thuluvath, A.J., Berendsen, M.A., dan Pandolfino, J.E., 2017. A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease. Diseases of the Esophagus, 30: 1–15.

Hunt, R., Armstrong, D., Katelaris, P., Afihene, M., Bane, A., Bhatia, S., dkk., 2017. World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophageal Reflux Disease. Journal of Clinical Gastroenterology, 51: 467–478.

Kao, S., Wu, D., Chuah, S., Kuo, C., Lu, C., Tai, W., dkk., 2015. Risk factors of incomplete response to proton pump inhibitor therapy in patients with mild erosive esophagitis. Advances in Digestive Medicine, 2: 18–24.

Kim, S.E., Kim, N., Oh, S., Kim, H.M., Park, M.I., Lee, D.H., dkk., 2015. Predictive Factors of Response to Proton Pump Inhibitors in Korean Patients With Gastroesophageal Reflux Disease. Journal of Neurogastroenterology and Motility, 21: 069–077.

Kuswono, A.D., Yurizali, B., dan Akbar, R.R., 2021. Kejadian Gastroesophageal Reflux Disease (GERD) Dengan GERD-Q Pada Mahasiswa Kedokteran. BRMJ, Vol I No 1, .

Lei, W.-Y., Chang, W.-C., Wen, S.-H., Yi, C.-H., Liu, T.-T., Hung, J.-S., dkk., 2019. Predicting factors of recurrence in patients with gastroesophageal reflux disease: a prospective follow-up analysis. Therapeutic Advances in Gastroenterology, 12: 175628481986454.

López-Colombo, A., Pacio-Quiterio, M.S., Jesús-Mejenes, L.Y., Rodríguez-Aguilar, J.E.G., López-Guevara, M., Montiel-Jarquín, A.J., dkk., 2017. Risk factors associated with gastroesophageal reflux disease relapse in primary care patients successfully treated with a proton pump inhibitor. Revista de Gastroenterología de México (English Edition), 82: 106–114.

May, Dianne, Thiman, Michael L, dan Rao, Satish S.C, 2020. Pharmacotherapy: A Pathophysiologic Approach, Eleventh edition. ed. McGraw Hill Medical, New York.

Ndraha, S., Oktavius, D., dan Sumampouw, J.L., 2016. Faktor-Faktor yang Berhubungan dengan Keberhasilan Terapi GERD. J. KedoktMeditek Volume 22, No. 60, 22: .

Patala, R., Tandi, J., Ulzmi, N., dan Fahruddin, F., 2021. Rasionalitas Penggunanaan Obat Pada.Pasien GERD Di Instalasi Rawat Inap Rumah Sakit Umum Anutapura Palu. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 6: 62.

Ren, L.-H., 2014. Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: A meta-analysis. World Journal of Gastroenterology, 20: 2412.

Sandhu, D.S. dan Fass, R., 2018. Current Trends in the Management of Gastroesophageal Reflux Disease. Gut and Liver, 12: 7–16.

Suherman, L., Ramdani, R., Septiani, V., Indrayani, W., Islamiyah, A.N., dan Hasyim, P., 2021. Pola Penggunaan Obat Pada Pasien Gastroesophageal Reflux Disease (Gerd) di Salah Satu Rumah Sakit di Bandung. Pharmacoscript, 4: 222–233.

Syam, A.F., Aulia, C., Renaldi, K., Simadibrata, M., Abdullah, M., dan Tedjasaputra, T.R. (Editor), 2013. Penatalaksanaan Penyakit Refluks Gastroesofageal (Gastroesophageal Reflux Disease/GERD) Di Indonesia. Pengurus Besar Perkumpulan Gastroenterologi Indonesia, Jakarta.

Zhang, H., Yang, Z., Ni, Z., dan Shi, Y., 2017. A Meta-Analysis and Systematic Review of the Efficacy of Twice Daily PPIs versus Once Daily for Treatment of Gastroesophageal Reflux Disease. Gastroenterology Research and Practice, 2017: 1–8.

DOI: https://doi.org/10.22146/farmaseutik.v20i4.93163