Systematic Review: Nanopartikel dari Bahan Obat Tradisional Indonesia

Theophani Bagas Pradana; Agung Endro Nugroho; Ronny Martien

doi:10.22146/farmaseutik.v19i4.91236

Systematic Review: Nanopartikel dari Bahan Obat Tradisional Indonesia

https://doi.org/10.22146/farmaseutik.v19i4.91236

Theophani Bagas Pradana⁽¹⁾, Agung Endro Nugroho^(2*), Ronny Martien⁽³⁾

(1) Mahasiswa Fakultas Farmasi Universitas Gadjah Mada
(2) Departemen Farmakologi dan Farmasi Klinik, Fakultas Farmasi Universitas Gadjah Mada
(3) Departemen Farmasetika, Fakultas Farmasi Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Tanaman obat di Indonesia memberikan berbagai manfaat, namun menghadapi kendala dalam aktivitas farmakologi, kelarutan dalam tubuh, dan disolusi obat yang rendah. Salah satu pendekatan untuk mengatasi masalah ini adalah melalui penggunaan sediaan nanopartikel. Penelitian ini bertujuan untuk meninjau penelitian sebelumnya tentang pembuatan sediaan nanopartikel dari tanaman obat di Indonesia dan manfaatnya dalam meningkatkan aktivitas farmakologi. Metode penelitian yang digunakan adalah systematic review dengan melakukan pencarian literatur melalui berbagai portal jurnal seperti Google Scholar, Science Direct, dan Scopus, dengan mempertimbangkan kriteria inklusi dan eksklusi. Jenis sediaan nanopartikel yang umum digunakan melibatkan Self-Nanoemulsifying Drug Delivery Systems (SNEDDS), nanoemulsi, dan nanosuspensi. Sediaan nanopartikel dari tanaman obat di Indonesia umumnya memiliki ukuran partikel yang memenuhi standar, berkisar antara 1-1000 nm, dan termasuk dalam golongan monodispersi dengan nilai polidispersitas <0,3. Hasil penelitian menunjukkan bahwa sediaan nanopartikel ini secara signifikan meningkatkan disolusi obat dibandingkan dengan sediaan non-nanopartikel. Peningkatan disolusi obat tersebut berdampak positif pada aktivitas farmakologi dari tanaman obat di Indonesia. Dari tinjauan literatur, dapat disimpulkan bahwa tanaman obat di Indonesia dapat dikembangkan menjadi sediaan nanopartikel, dan penerapan sediaan nanopartikel ini dapat meningkatkan aktivitas farmakologi tanaman obat tersebut.

Keywords

nanopartikel; tanaman obat; Aktivitas Farmakologi

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DOI: https://doi.org/10.22146/farmaseutik.v19i4.91236