Comparison Among Proton Pump Inhibitor Inducing Pneumonia in Hospital: Narrative Review

https://doi.org/10.22146/farmaseutik.v20i3.88612

Juwita Permata Sari(1*), Agung Endro Nugroho(2), Widyati Widyati(3)

(1) Master of Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada
(2) Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Pertahanan
(*) Corresponding Author

Abstract


Critically ill patients requiring intensive care unit (ICU) are highly vulnerable to the emergence of stress-related gastrointestinal bleeding, a condition closely associated with unfavorable clinical outcomes. Despite advancements in preventive measures, antimicrobial therapies, and supportive medical care, ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia (HAP) continue to effect morbidity and mortality rates significantly. Hospital-acquired pneumonia (HAP) is characterized as a form of pneumonia that does not manifest during the period of hospital admission but rather emerges 48 hours or later after the patient has been admitted. In contrast, VAP occurs after 48 hours of having an endotracheal tube in place. Proton pump inhibitors (PPIs) are used prophylactically to manage stress ulcers in critically ill patients. However, recent scholarly literature has drawn attention to a potential link between using acid-suppressing medications and an increased susceptibility to pneumonia. The precise mechanism through which these acid suppressors might elevate the risk of pneumonia remains unclear. The primary objective of this study was to assess the prevalence of pneumonia associated with different types of proton pump inhibitors. We conducted an extensive literature search using keywords such as "(omeprazole or pantoprazole or lansoprazole or esomeprazole or rabeprazole), ICU, Pneumonia" on two prominent electronic databases: Scopus and PubMed. We identified fourteen articles meeting our inclusion criteria, which were categorized into four groups based on the type of proton pump inhibitor: omeprazole, esomeprazole, lansoprazole, and pantoprazole. The results of this narrative review revealed varying risk levels associated with using different proton pump inhibitors for pneumonia. Esomeprazole had the highest risk level, at 48.84%, followed by lansoprazole at 27.85%, omeprazole at 22.5%, and pantoprazole at 19.94%.


Keywords


Pneumonia; Omeprazole; Pantoprazole; Lansoprazole; Esomeprazole

Full Text:

PDF


References

Kumar S, Ramos C, Garcia-Carrasquillo RJ, Green PH, Lebwohl B. Incidence and risk factors for gastrointestinal bleeding among patients admitted to medical intensive care units. Frontline Gastroenterol. 2017;8(3):167-173. doi:10.1136/flgastro-2016-100722

Kalil AC, Metersky ML, Klompas M, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):e61-e111. doi:10.1093/cid/ciw353

Varon J. Handbook of Critical and Intensive Care Medicine. Springer International Publishing; 2021. doi:10.1007/978-3-030-68270-5

Alhazzani W, Alshamsi F, Belley-Cote E, et al. Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials. Intensive Care Med. 2018;44(1):1-11. doi:10.1007/s00134-017-5005-8

Lambert AA, Lam JO, Paik JJ, Ugarte-Gil C, Drummond MB, Crowell TA. Risk of Community-Acquired Pneumonia with Outpatient Proton-Pump Inhibitor Therapy: A Systematic Review and Meta-Analysis. Deshpande A, ed. PLOS ONE. 2015;10(6):e0128004. doi:10.1371/journal.pone.0128004

Nguyen PA, Islam M, Galvin CJ, et al. Meta-analysis of proton pump inhibitors induced risk of community-acquired pneumonia. Int J Qual Health Care J Int Soc Qual Health Care. 2020;32(5):292-299. doi:10.1093/intqhc/mzaa041

Al Sulaiman K, Al Aamer K, Al Harthi A, et al. Comparison between esomeprazole 20 mg Vs 40 mg as stress ulcer prophylaxis (SUP) in critically ill patients: A retrospective cohort study. Pharmacol Res Perspect. 2020;8(4). doi:10.1002/prp2.624

Bashar FR, Manuchehrian N, Mahmoudabadi M, Hajiesmaeili MR, Torabian S. Effects of Ranitidine and Pantoprazole on Ventilator-Associated Pneumonia: A Randomized Double-Blind Clinical Trial. Tanaffos. 2013;12(2):16-21. Accessed August 25, 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153243/

Krag M, Marker S, Perner A, et al. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. N Engl J Med. 2018;379(23):2199-2208. doi:10.1056/NEJMoa1714919

Khorvash F, Abbasi S, Meidani M, Dehdashti F, Ataei B. The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients. Adv Biomed Res. 2014;3:52. doi:10.4103/2277-9175.125789

Lin CC, Hsu YL, Chung CS, Lee TH. Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial. J Formos Med Assoc. 2016;115(1):19-24. doi:10.1016/j.jfma.2014.10.006

Liu B lin, Li B, Zhang X, et al. A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage: Clinical article. J Neurosurg. 2013;118(1):115-120. doi:10.3171/2012.9.JNS12170

Miano TA, Reichert MG, Houle TT, MacGregor DA, Kincaid EH, Bowton DL. Nosocomial Pneumonia Risk and Stress Ulcer Prophylaxis. Chest. 2009;136(2):440-447. doi:10.1378/chest.08-1634

Moayyedi P, Eikelboom JW, Bosch J, et al. Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin. Gastroenterology. 2019;157(3):682-691.e2. doi:10.1053/j.gastro.2019.05.056

Nikpour S, Mokhber A, Hajiesmaeili M, et al. Prediction of ventilator-associated pneumonia in patients undergoing stress ulcer prophylaxis: A longitudinal descriptive study in Iran. J Kerman Univ Med Sci. 2020;27(6):501-509. doi:10.22062/JKMU.2020.91525

Salarian S, Mirrahimi B, Hadavand F, Gharehdaghi M, Bagheri B. Impact of Intravenous Pantoprazole versus Oral Pantoprazole on Gastric pH in Pediatric Intensive Care Unit: A Randomized Trial. J Chem Health Risks. 2021;11(Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases). doi:10.22034/jchr.2021.1915527.1223

Selvanderan SP, Summers MJ, Finnis ME, et al. Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study*. Crit Care Med. 2016;44(10):1842-1850. doi:10.1097/CCM.0000000000001819

Somberg L, Morris J, Fantus R, et al. Intermittent Intravenous Pantoprazole and Continuous Cimetidine Infusion: Effect on Gastric pH Control in Critically Ill Patients at Risk of Developing Stress-Related Mucosal Disease. J Trauma Inj Infect Crit Care. 2008;64(5):1202-1210. doi:10.1097/TA.0b013e31815e40b5

Takatori K, Yoshida R, Horai A, et al. Therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding. J Gastroenterol. 2013;48(10):1105-1110. doi:10.1007/s00535-012-0725-6

Wu H, Jing Q, Wang J, Guo X. Pantoprazole for the prevention of gastrointestinal bleeding in high-risk patients with acute coronary syndromes. J Crit Care. 2011;26(4):434.e1-434.e6. doi:10.1016/j.jcrc.2010.12.007

MacLaren R, Reynolds PM, Allen RR. Histamine-2 Receptor Antagonists vs Proton Pump Inhibitors on Gastrointestinal Tract Hemorrhage and Infectious Complications in the Intensive Care Unit. JAMA Intern Med. 2014;174(4):564-574. doi:10.1001/jamainternmed.2013.14673

Chen C, Liu H, Duan R, Wang F, Duan L. The efficacy and safety of acid suppressants for gastrointestinal bleeding prophylaxis in cardiac care unit patients. J Gastroenterol Hepatol. 2021;36(8):2131-2140. doi:10.1111/jgh.15432

Li F, Liu H, Zhang L, et al. Effects of Gastric Acid Secretion Inhibitors for Ventilator-Associated Pneumonia. Front Pharmacol. 2022;13. Accessed January 6, 2023. https://www.frontiersin.org/articles/10.3389/fphar.2022.898422

Huang M, Han M, Han W, Kuang L. Proton pump inhibitors versus histamine-2 receptor blockers for stress ulcer prophylaxis in patients with sepsis: a retrospective cohort study. J Int Med Res. 2021;49(6):03000605211025130. doi:10.1177/03000605211025130

Song MJ, Kim S, Boo D, et al. Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit. Sci Rep. 2021;11:18467. doi:10.1038/s41598-021-98069-7

Mekhail A, Young P, Mekhail AM, et al. Stress Ulcer Prophylaxis in Cardiac Surgery: A Retrospective Cohort Study to Analyze the Effects of SUP Cessation. J Intensive Care Med. Published online April 24, 2023:8850666231171327. doi:10.1177/08850666231171327

Kondo Y, Ohbe H, Matsui H, Fushimi K, Tanaka H, Yasunaga H. Proton pump inhibitors versus histamine-2 receptor antagonists for stress ulcer prophylaxis during extracorporeal membrane oxygenation: a propensity score-matched analysis. BMJ Open. 2020;10(9):e037534. doi:10.1136/bmjopen-2020-037534

Cunningham R, Jones L, Enki DG, Tischhauser R. Proton pump inhibitor use as a risk factor for Enterobacteriaceal infection: a case-control study. J Hosp Infect. 2018;100(1):60-64. doi:10.1016/j.jhin.2018.05.023

Alagha H, Mohammed Al Mabhouh N. EVALUATION OF CURRENT PRACTICE OF STRESS ULCER PROPHYLAXIS IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS IN THE GAZA STRIP- PALESTINE. Bull Pharm Sci Assiut. 2022;45(2):845-857. doi:10.21608/bfsa.2022.271660

Wang YH, Svanström H, Wintzell V, Ludvigsson JF, Pasternak B. Association between proton pump inhibitor use and risk of pneumonia in children: nationwide self-controlled case series study in Sweden. BMJ Open. 2022;12(4):e060771. doi:10.1136/bmjopen-2022-060771



DOI: https://doi.org/10.22146/farmaseutik.v20i3.88612

Article Metrics

Abstract views : 306 | views : 76

Refbacks

  • There are currently no refbacks.


Majalah Farmaseutik Indexed by:

   
 
Creative Commons Licence
 
 
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.