Narrative Review: Efektivitas Sitikolin vs Asam Folat dalam Menurunkan Disabilitas Neurologis Pasien Stroke Iskemik Akut

https://doi.org/10.22146/farmaseutik.v20i1.83668

Ayuningtyas Galuh Purwandityo(1*), Zullies Ikawati(2), Rizaldy Taslim Pinzon(3)

(1) Fakultas Farmasi Universitas Gadjah Mada Yogyakarta
(2) Fakultas Farmasi Universitas Gadjah Mada Yogyakarta
(3) Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Stroke adalah penyebab kedua kematian di seluruh dunia serta menyebabkan disabilitas fisik dan neurologis jangka panjang. Keparahan defisit neurologis dini adalah penentu yang paling penting dari hasil fungsional akhir pada stroke iskemik akut. Tujuan dari penelitian ini adalah membandingkan efektivitas penggunaan sitikolin dan asam folat dalam memperbaiki disabilitas neurologis pasien stroke iskemik akut. Penelitian ini dilakukan dengan cara narrative review dan dilakukan dalam empat tahap yaitu penentuan kata kunci, kriteria inklusi dan eksklusi, seleksi literatur, dan analisis hasil. Pencarian literatur dilakukan melalui database elektronik seperti PubMed, Scopus, Science Direct, Wiley Online Library dan Springer Link. Berdasarkan review yang dilakukan diperoleh data bahwa sitikolin terbukti neuroprotektor yang aman dan efektif diberikan pra, pasca serta pengobatan stroke jangka panjang sebab mampu menurunkan disabilitias neurologis. Pada penggunaan asam folat juga cenderung terbukti efektif untuk mencegah stroke, namun biasanya dikombinasi dengan vitamin B12 atau vitamin B6. Selain itu, data terkait fungsi asam folat dalam menurunkan disabilitas neurologis pasca stroke atau sebagai pengobatan jangka panjang masih sangat terbatas.


Keywords


Sitikolin; asam folat; stroke iskemik akut; skor disabilitas neurologis

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References

1. Coupland AP, Thapar A, Qureshi MI, Jenkins H, Davies AH. The definition of stroke. J R Soc Med. 2017;110(1):9-12.

2. Saver JL, Altman H. Relationship Between Neurologic Deficit Severity and Final Functional Outcome Shifts and Strengthens During First Hours After Onset. Stroke. 2012;43(6):1537-1541.

3. Álvarez-Sabín J, Román G. The Role of Citicoline in Neuroprotection and Neurorepair in Ischemic Stroke. Brain Sciences. 2013;3(4):1395-1414.

4. Abdelghany H, Elsayed M, Elmeligy A, Hatem G. Prediction of acute cerebrovascular stroke disability using mSOAR score (Stroke subtype, Oxfordshire Community Stroke Project, age, mRS and NIHSS). Egypt J Neurol Psychiatry Neurosurg. 2023;59(1):21.

5. Teresa D, Pinzon RT, Adisaputro S. Baseline Stroke Severity as a Predictor of 30-Day Post-Ischemic Stroke Disability Outcome. JKB. Published online April 9, 2022.

6. Atiş ŞE, Bozan Ö, Ferhatlar ME, Kalkan A. Effectiveness of the Full Outline of UnResponsiveness Score in Patients with Acute Ischemic Stroke. Cureus. Published online March 5, 2022.

7. Wiśniewski A, Filipska K, Puchowska M, Piec K, Jaskólski F, Ślusarz R. Validation of a Polish version of the National Institutes of Health Stroke Scale: Do moderate psychometric properties affect its clinical utility? Barboza MA, ed. PLoS ONE. 2021;16(4):e0249211.

8. Quinn TJ, Langhorne P, Stott DJ. Barthel Index for Stroke Trials: Development, Properties, and Application. Stroke. 2011;42(4):1146-1151.

9. Uyttenboogaart M, Luijckx GJ, Vroomen PCAJ, Stewart RE, Keyser J. Measuring disability in stroke: relationship between the modified Rankin scale and the Barthel index. J Neurol. 2007;254(8):1113-1117.

10. Lee SY, Kim DY, Sohn MK, et al. Determining the cut-off score for the Modified Barthel Index and the Modified Rankin Scale for assessment of functional independence and residual disability after stroke. Wu O, ed. PLoS ONE. 2020;15(1):e0226324.

11. Martinov M, Gusev E. Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. JEP. Published online October 2015:17.

12. Wahyudi R, Hasmono D, Fitrina R, Armal K. Injected Citicoline Improves Impairment and Disability during Acute Phase Treatment in ischemic Stroke Patients. FMI. 2016;51(4):245.

13. Yang Y hui, Lei L, Bao Y ping, Zhang L. An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid. Front Mol Biosci. 2022;9:783793.

14. Overgaard K. The Effects of Citicoline on Acute Ischemic Stroke: A Review. Journal of Stroke and Cerebrovascular Diseases. 2014;23(7):1764-1769.

15. Pinzon R, Sanyasi R. Is There Any Benefit of Citicoline For Acute Ischemic Stroke? Systematicreview Of Current Evidences. JCR. Published online 2018:11-14.

16. Agarwal A, Vishnu VY, Sharma J, et al. Citicoline in acute ischemic stroke: A randomized controlled trial. De Rosa S, ed. PLoS ONE. 2022;17(5):e0269224.

17. Martí-Carvajal AJ, Valli C, Martí-Amarista CE, Solà I, Martí-Fàbregas J, Bonfill Cosp X. Citicoline for treating people with acute ischemic stroke. Cochrane Stroke Group, ed. Cochrane Database of Systematic Reviews. 2020;2020(12).

18. Dávalos A, Alvarez-Sabín J, Castillo J, et al. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet. 2012;380(9839):349-357.

19. Secades JJ, Alvarez-Sabín J, Castillo J, et al. Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Trials. Journal of Stroke and Cerebrovascular Diseases. 2016;25(8):1984-1996.

20. Mazaheri S, Associate Professor, Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, Darvish M, et al. A Comparative Study on the Effect of Citicoline on Acute Ischemic and Hemorrhagic Stroke. Avicenna J Clin Med. 2018;25(1):20-27.

21. Premi E, Cantoni V, Benussi A, et al. Citicoline Treatment in Acute Ischemic Stroke: A Randomized, Single-Blind TMS Study. Front Neurol. 2022;13:915362.

22. Jasielski P, Piędel F, Piwek M, Rocka A, Petit V, Rejdak K. Application of Citicoline in Neurological Disorders: A Systematic Review. Nutrients. 2020;12(10):3113.

23. Kong X, Huang X, Zhao M, et al. Platelet Count Affects Efficacy of Folic Acid in Preventing First Stroke. Journal of the American College of Cardiology. 2018;71(19):2136-2146.

24. Li L, Ma X, Zeng L, et al. Impact of homocysteine levels on clinical outcome in patients with acute ischemic stroke receiving intravenous thrombolysis therapy. PeerJ. 2020;8:e9474.

25. Kirmit A, Ege A, Basarili A, Karadag M. Correlation between homocysteine levels and stroke in patients with acute ischemic stroke. Med-Science. 2018;(0):1.

26. Yuan S, Mason AM, Carter P, Burgess S, Larsson SC. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021;19(1):97.

27. Poddar R. Hyperhomocysteinemia is an emerging comorbidity in ischemic stroke. Experimental Neurology. 2021;336:113541.

28. Yılmaz E, Sarıönder Gencer E, Arsava EM, Topcuoğlu MA. The Effect of Homocysteine Levels on Thrombolytic Treatment in Acute Ischemic Stroke. tnd. 2023;28(4):242-247.

29. Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, Bilotta F. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. JCM. 2022;11(2):394.

30. Wang L, Cui W, Nan G, Yu Y. Meta-analysis revealsprotective effects ofvitamin B on stroke patients. Translational Neuroscience. 2015;6(1):150-156.

31. Huo Y, Qin X, Wang J, et al. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis: Folic acid supplementation in stroke prevention. International Journal of Clinical Practice. 2012;66(6):544-551.

32. Hankey GJ. B vitamins for stroke prevention. Stroke Vasc Neurol. 2018;3(2):51-58.

33. Xia XS, Li X, Wang L, Wang JZ, Ma JP, Wu CJ. Supplementation of folic acid and vitamin B12 reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke. Journal of Clinical Neuroscience. 2014;21(9):1586-1590.

34. Song J, Xu C, Zhang J, Gao L. From clinical appearance to accurate management in acute ischemic stroke patients: With the guidance of innovative traditional Chinese medicine diagnosis. Brain Behav. 2019;9(10).

35. Rakasiwi R, Ikawati Z, Setyopranoto I. Efektivitas Penggunaan Asam Folat Dalam Memperbaiki Luaran Fungsional Pasien Stroke Iskemik Akut. Published online 2021.



DOI: https://doi.org/10.22146/farmaseutik.v20i1.83668

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