Gambaran Hubungan Regimen Dosis Danefek Samping Kemoterapi pada Pasien Kanker di RSUD Prof Dr. Margono Soekarjo Purwokerto Periode Bulan Januari-Februari Tahun 2019

https://doi.org/10.22146/farmaseutik.v15i2.47664

Endang Darmawan(1), Reina Melani(2*), Budi Raharjo(3)

(1) Magister Farmasi Klinis, Universitas Ahmad Dahlan
(2) Magister Farmasi Klinis, Universitas Ahmad Dahlan
(3) RSUD Prof. Dr. Margono Soekarjo Purwokerto
(*) Corresponding Author

Abstract


Pengobatan kanker dikenal beberapa cara, salah satunya adalah kemoterapi, yaitu pengobatan dengan menggunakan obat-obatan yang dapat menghambat atau membunuh sel-sel kanker. Pengobatan dengan kemoterapi banyak menimbulkan efek samping. Tujuan penelitian yaitu untuk mengetahui gambaran efek samping kemoterapi pasien kanker di RSUD Prof Dr Margono Soekarjo Purwokerto dan mengetahui hubungan antara regimen dosis terhadap efek samping kemoterapi. Penelitian ini menggunakan rancangan secara prospektif dengan pendekatan study metode cross sectional. Gambaran efek samping kemoterapi yang banyak terjadi di RSUD Prof. Dr Margono Soekarjo Purwokerto pada pasien 10 besar kanker periode bulan Januari – Februari 2019 adalah alergi sebanyak 15 pasien (10%), disusul dengan mual sebanyak 11 pasien (7.3%) sedangkan leukopenia dan neutropenia masing-masing sebanyak  5 pasien (4.7 %). Kesimpulan pada peneltian ini yaitu bahwa ada hubungan yang signifikan antara pemberian obat kemoterapi terhadap terjadinya efek samping setelah menjalani kemoterapi (p< 0,05)


Keywords


kanker; regimen dosis; efek samping obat; kemoterapi

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References

Anders Jocobsen, 2002, Dose effect Relationship of Bolus 5- Fluoro Uracil in the Treatment of Advance Colorectal Cancer, Ake Berglund, Bengt Glimelius, Jan-Erik Frodin, Flemming Hansen, Mogens Kjer, Ebbe Lindegaard, Departement of Oncology, Vejle Hospital, DK-7100 Vejle, Denmark

Apdani, R., 2011, Karakteristik Penderita Kanker Paru yang di Rawat Inap di Bangsal Paru RSUD Dr Soedarsono Pontianak Periode 1 Januari – 31 Desember 2010, Skripsi, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Tanjungpura, Pontianak.

Arkerstedt, T, Knutsson A, Narusyte J, Svedberg P, Kecklund G, Alexanderson, K ,2015, BMJ Open Night Work and Breast Cancer in Woman : A Swedish Cohort Study.

Belkahla, H.,Herlem, G., Picaud, F., Gharbi, T., Hemadi, M., Ammar, S., Micheu, O., 2017, TRAIL-NP hybrid for cancer therapy : review, Nanoscale doi : 10.1039/c7nr01469d

Bulsink. Arjan, Alex LT, 2013, Characteristic of potential drug-related problem among oncology patients, International journal of Clinical Pharmacy, University of Groningen

Damayanti, Ika Putri 2013, Faktor-faktor yang Berhubungan Dengan Kejadian Kanker Serviks di RSUD Arifin Achmad Pekanbaru Tahun 2008-2010, Jurnal Kesehatan Komunitas Volume 2 No 3.

Fenga C, 2016, Occupational Exposure and Risk of Breast Cancer, Biomedical Report, Spandidos Publication.

Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S,. Mathers, C., Rebelo, M.,Parkin, D.M,.Forman, D., Bray, F., 2014, Cancer incidence and mortality worldwide : soueces , method and major patterns in GLOBOCAN 2012, Int J Cancer 1 : 136(5):E359-86, DOI:10.1002/ijc.29210

Grothey, A, Sobrero A.F, Shields A.F,Yoshino, Paul, J, 2018, Duration of Adjuvant Chemotherapy for Stage III Colon Cancer, The New England Journal of Medicine Vol 378 no 13

Hashiguchi,Y,Kasai Mari, Fukuda Takeshi, Ichimura T, Yasui T, Sumi, T ,2015, Chemotherapy Induced Neutropenia & Febrile Neutropenia in patient with Gynecologic Malignancy

Howley, K Elaine, 2017, Which Chemotherapy Treatments Are Most Commonly Used for Breast Cancer ?, US News Health, 16 Nov 2017

Medicinus, 2016. Mengenal Lebih Dalam tentang Kanker, Vol 29, No 1.http : // cme.medicinus.co/file.php/i/IN_DEPTH_REPORTING_Mengenal_Lebih_Dalam_tentang_Kanker.pdf.Diakses 5 februari 2018

Morrison, Vicki A, Wong Mitchell, Hershman Dawn, Campos Luis, Ding Beiying, Malin Jennifer, 2007, Observational study of Prevalence of Febril Neutropenia in Patients Who received Filgrastim or Pegfilgrastim Associated With 3-4 week Chemotherapy Regimen in Community Oncology Practices, Journal Of Managed Care Pharmacy Vol 13 No 4

Musolino,C, Allegra A, Minciullo,PL, Gangemi.S, 2014, Allergy and Risk of Hematologic Malignancies Association and Mechanism, Leukimia Research, Elsevier.

Patel, D, Jyoti,2018 Managing Side Effect of Chemotherapy Cancer , diakses pada 25/5/2019

Pecorino, L., 2012, Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics, Third Edition, Oxford University Press, New York

Remesh,A., 2012, Toxicities of anticancer drugs and its management, International Journal of Basic & Clinical Pharmacology

Sukardja, Gede dewa , 2000, Onkologi Klinik, Airlangga University Press, Surabaya

Ukraintseva, V,Svetlana, Yashin I Anatoli 2003 Individual Aging and Cancer Risk : How Are They Related?, Demographic Research, Vol 9, Article 8 Page 163-196.

White, C Mary, Holman M Dawn, Henly S.Jane 2015, Age and Cancer Risk, American Journal Of Preventive Medicine.

World Health Organization , 2017, Cancer , http : //www.who.int/cancer/en/, diakses pada 14 februari 2018



DOI: https://doi.org/10.22146/farmaseutik.v15i2.47664

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