PIPER BETLE EXTRACT PATCH (Piper betle L): THE INFLUENCE IN ADDING REALESE ENHANCER SUBSTANCES TOWARDS PHYSIOCHEMICAL AND ANTIBACTERIAL ACTIVITY

https://doi.org/10.22146/farmaseutik.v12i2.26452

Mufrod Mufrod(1*), Suwaldi Suwaldi(2), Subagus Wahyuono(3)

(1) Fakultas Farmasi, Universitas Gadjah Mada
(2) Fakultas Farmasi, Universitas Gadjah Mada
(3) Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Piper betle extract has an antibactery activity with eugenol as a major active substance its sparingly soluble in water. Piper betle extract mucoadhesive patch was a suitable form used in oral cavity for inhibiting Streptococcus mutans a bactery that caused plaque. Physicochemical properties and the release of active substance affect the acceptability of patch as well as antibacterial activity. Glycerin, propilen glycol and tween 80 are the substances(release enhancer substances/RES) that affect the flexibilty and release the active substance from patc. The aim of the research was to investigate the influance of the concentration of extract and addition of RES to the physicochemical and antibacterial activity of the patchs. Extract obtained by infusion method. Extract piper betle made based on variation concentration of extract 0,5%, 1%,2%,3% ,4% and adding release enhancer subtances glycerin, propilen glycol and tween 80. Patches produced tested for physicochemical properties including uniformity of weight, surface pH, folding endurance, swelling index and antibactery activity. Data obtained were descriptiv and statisticaly analize. The result showed that release enhancer substances affect the physicochemical properties and antibactery activity of the patches. The adding release enhancer substances increasing the value of folding endurance and swelling index and antibactery activity of patch.

Keywords


Piper betle extract, patch, release enhancer substances, hysiochemical, bacterial activity

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References

Depkes RI, 1981, Pemanfaatan Tanaman Obat, Direktorat Jenderal Pengawasan Obat dan Makanan, Depkes RI, Jakarta, 2-10 Depkes RI ,2000, Parameter Standar Umum Ekstrak Tumbuhan Obat dan Makanan, Cetakan Pertama, Depkes RI, Ditjen POM, Direktorat Pengawasan Obat Tradisional, 5-12 Deshmane, S.V., Channawar, M. A., Chandewar, A.V., Joshi, U. M. & Biyani, K.R., 2009, Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Verapamil HCl, International Journal of Pharmacy and Pharmaceutical Science, 1 (1), 216-229 Kenneth E. Ezealisiji1, Chika J. Mbah2*, Patience O.Osadebe2,2015, Aqueous Solubility Enhancement of Mirtazapine: Effect of Cosolvent and Surfactant, Pharmacology & Pharmacy, 6, 471-476 Kaur,A., dan Kaur,G., 2012, Mucoadhesive buccal patches based on interpolymer complexes of chitosan pectin for delivery of carvedilol, Saudi Pharmaceutical Journal, 20, 21-27 Kohsaku Kawakami∗, Naohiko Oda, Kyoko Miyoshi, Takeshi Funaki, Yasuo Ida, 2006, Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents , european journal of pharmaceutical sciences 2 8 , 7–14 Khurana, R., Ahuja, A., dan Khar, R.K., 2000, Development and Evaluation of Mucoadhesive Films of Miconazole Nitrate, Ind. J. Pharm. Sci., 60, 449-453. Mardisiswojo,S dan Harsono.R.,1985, Cabe Puyang Warisan Nenek Moyang, PN. Balai Pustaka, 189-190,215 Mollet, H., and Grubenmann, A., 2001, Formulation Technology, Wiley-VCH, Weinheim, New York, 341 – 342. Naudeh,G.D., Khazaeli,P., dan Rahmani, P.,2008, Study of Effect of Polyethylene glycol Sorbitan Esters Surfactans Group on Biological Membranes, Int.J.Pharm.,4. (1), 27-33. Sutton, S., 2006, Measurement of Cell Concentration in Suspension by Optical Density, Pharmaceutical Microbiology, Forum Newsletter, 12(8), 3- 9.



DOI: https://doi.org/10.22146/farmaseutik.v12i2.26452

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