Immunonutrition and Hepatoprotectant Aspects of Moringa Oleifera Leaf Nanoemulsion Syrup as an Antituberculosis Adjuvant for Children with Tuberculosis

https://doi.org/10.22146/jtbb.68291

Nyoman Budhi Wirananda Setiawan(1), Agus Indra Yudhistira Diva Putra(2), Made Indira Dianti Sanjiwani(3), Agung Wiwiek Indrayani(4*), Ida Ayu Ika Wahyuniari(5)

(1) Undergraduate Student of School of Medicine and Medical Profession, Faculty of Medicine, Udayana University, Bali
(2) Undergraduate Student of School of Medicine and Medical Profession, Faculty of Medicine, Udayana University, Bali
(3) Undergraduate Student of School of Medicine and Medical Profession, Faculty of Medicine, Udayana University, Bali
(4) Department of Pharmacology and Therapy, Faculty of Medicine, Udayana University, Bali
(5) Department of Histology, Faculty of Medicine, Udayana University, PB Sudirman Street, Denpasar, Bali, Indonesia, 80232
(*) Corresponding Author

Abstract


Tuberculosis in children is a global health problem that decreases the quality of life of children. Based on data from the Indonesian Ministry of Health in 2016, nearly 69.000 children had tuberculosis and the case keeps increasing every year. Moringa oleifera leaf nanoemulsion syrup has immunonutrition and hepatoprotectant effects in children with tuberculosis. Moringa oleifera leaf nanoemulsion syrup contains proteins, micronutrients, and minerals which have a biological role as an immunity agent and prevent toxic effects of tuberculosis drugs. Until now, the use of Moringa oleifera leaf nanoemulsion syrup has been carried out for the immunomodulatory and hepatoprotective aspects. Immunomodulatory and hepatoprotective aspects will be discussed further in this literature review. The sources of articles in this literature review are pubmed.com, ncbi.com, plosone.com, sciencedirect.com, and googleschoolar.com from 2010-2020, except when there is no new research against the article. The authors searched for the keywords: "immunonutrition", "tuberculosis in children", "hepatoprotectant", and "Moringa oleifera". As an immunomodulator, Moringa oleifera leaf nanoemulsion syrup stimulate activation of polimorphonuclear (PMN) cells. As a hepatoprotectant, Moringa oleifera leaf nanoemulsion syrup work by reducing the side effects of conventional tuberculosis drugs such as rifampicin by suppressing the action of cytochrome p450 (CYP1A2 and CYP2B), thus decreases the production of toxic hydrazine which causes liver toxicity in tuberculosis patient. Seeing the various interests in the immunomodulatory and hepatoprotective aspects, Moringa oleifera leaf nanoemulsion syrup can be used as an adjuvant therapy in overcoming tuberculosis in children by stimulating the activation of immunity cell such as PMN, increasing nutrient absorption, and suppressing the action of cytochrome p450 (CYP1A2 and CYP2B).


Keywords


Hepatoprotectant, Immunonutrition, Moringa oleifera, Secondary Metabolite, Tuberculosis in Children

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DOI: https://doi.org/10.22146/jtbb.68291

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