Dermatosis pada Ruminansia akibat Defisiensi Vitamin C: Ulasan Singkat

Yanuartono Yanuartono; Soedarmanto Indarjulianto; Alfarisa Nururrozi; Dhasia Ramandani; Hary Purnamaningsih

doi:10.22146/jsv.71186

Dermatosis pada Ruminansia akibat Defisiensi Vitamin C: Ulasan Singkat

https://doi.org/10.22146/jsv.71186

Yanuartono Yanuartono⁽¹⁾, Soedarmanto Indarjulianto^(2*), Alfarisa Nururrozi⁽³⁾, Dhasia Ramandani⁽⁴⁾, Hary Purnamaningsih⁽⁵⁾

(1) Universitas Gadjah Mada
(2) Universitas Gadjah Mada
(3) Universitas Gadjah Mada
(4) Universitas Gadjah Mada
(5) Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Vitamin C bersifat esensial untuk mamalia, termasuk manusia, primata, dan marmut, meskipun mamalia lain, seperti ruminansia, babi, kuda, anjing, dan kucing, dapat mensintesis vitamin C dari glukosa di hati. Ruminansia pada dasarnya bergantung pada sintesis endogen karena vitamin C asal pakan sebagian besar dirusak semuanya oleh mikroorganisme rumen. Dengan demikian, ruminansia lebih bergantung vitamin C endogen untuk mencukupi kebutuhan tubuhnya guna memenuhi persyaratan fisiologis dibandingkan dengan hewan lain. Meskipun demikian, ruminansia muda lebih rentan terhadap defisiensi vitamin C karena biasanya hanya memperoleh diet dengan kandungan vitamin C yang rendah. Produksi vitamin C endogen pada ruminansia muda dapat mencapai tingkat maksimal setelah umur 16 minggu. Konsentrasi vitamin C pada ruminansia muda yang rendah tersebut berpotensi menimbulkan dermatosis pada ruminansia muda. Tulisan ini bertujuan untuk mengulas secara singkatnya defisiensi vitamin C yang terkait dengan dermatosis pada ruminansia.

Keywords

dermatosis; ruminansia; ruminansia muda; vitamin C

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References

Al-Autaish, H.N. (2019). The influence of vitamin C deficiency on dermatosis in neonatal dairy calves. Kufa Journal For Veterinary Medical Sciences.10 (1): 47-55.

Almohanna, H.M., Ahmed,A.A., Tsatalis,J.P. and Tosti, A. (2019). The Role of Vitamins and Minerals in Hair Loss: A Review Dermatol Ther (Heidelb). ; 9(1): 51–70. doi: 10.1007/s13555-018-0278-6

Amaya, I., Osorio, S., Martinez-Ferri, E., Lima-Silva, V., Doblas, V.G., FernándezMuñoz, R., Fernie, A.R., Botella, M.A. and Valpuesta, V. (2015). Increased antioxidant capacity in tomato by ectopic expression of the strawberry D – galacturonate reductase gene. Biotechnol. J. 10(3): 490–500. doi: 10.1002/biot.201400279

Anoushepour, A., Sakha, M. and Mortazavi, P. (2013). A clinical case: vitamin C-responsive dermatosis in a Holstein native cross bull calf. Turk J Vet Anim Sci. 37(2): 234-237 doi:10.3906/vet-1112-4

Badejo, A.A., Wada, K., Gao, Y., Maruta, T., Sawa, Y., Shigeoka, S. and Ishikawa, T. (2012). Translocation and the alternative D-galacturonate pathway contribute to increasing the ascorbate level in ripening tomato fruits together with the D-mannose/L-galactose pathway. J. Exp. Bot. 63(1): 229–239. doi: 10.1093/jxb/ err275

Baldwin, T.J., Rood, K.A., Kelly, E.J. and Hall. J.O. (2012). Dermatopathy in juvenile Angus cattle due to vitamin A deficiency. Journal of Veterinary Diagnostic Investigation. 24(4): 763–766 DOI: 10.1177/1040638712445767

Barnes, M.J. (1975). Function of ascorbic acid in collagen metabolism. Ann. N.Y. Acad. Sci., 258: 264–277.

Blair, L. and Cummins, K. (1984). Effect of dietary ascorbic acid on blood immunoglobulins concentration in dairy cows. J. Dairy Sci. 67(Suppl. 1):138.(Abstr.)

Bobe, G., Young, J.W. and Beitz, D.C. (2004). Invited review: pathology, etiology, prevention, and treatment of fatty liver in dairy cows. J Dairy Sci. 87(10):3105-3124. DOI: 10.3168/jds.S0022-0302(04)73446-3

Bouda, J., Jagos, P., Dvorak, R. and Ondrova, J. (1980). Vitamin E and C in the blood plasma of cows and their calves fed from buckets. Acta Vet Brono. 49:53–58.

Chaiyotwittayakun, A., Erskine, R.J, Bartlett, T.H., Herdt, P.M. and Harmon, R.J. 2002). The effect of ascorbic acid and L-histidine therapy on acute mammary inflammation in dairy cattle. J Dairy Sci. 85(1): 60–67. https://doi.org/10.3168/jds.S0022-0302(02)74053-8

Chambial, S., Dwivedi, S., Shukla, K.K., John, P.J. and Sharma, P. (2013). Vitamin C in Disease Prevention and Cure: An Overview. Ind J Clin Biochem. 28(4):314–328. DOI 10.1007/s12291-013-0375-3

Cole, C.L., Rasmussen, R.A. and Thorp F., Jr. (1944). Dermatosis of the ears, cheeks, neck and shoulders in young calves. Vet Med. 39:204–206.

Combs, G.F. (2008). Vitamin C. In: The vitamins: fundamental aspects in nutrition and health, third edition (Ed. G. F. Combs) Academic Press, San Diego, CA, USA. pp. 235-263.

Cummins, K.A., Bush, L.J. and White, T.W. (1992). Ascorbate in Cattle: A Review1. The Professional Animal Scientist. 8(1): 22-29

Devaki, S.J. and Raveendran, R.L. (2017). Vitamin C: Sources, Functions, Sensing and Analysis, Vitamin C, Amal H. Hamza, IntechOpen, DOI: 10.5772/intechopen.70162. Available from: https://www.intechopen.com/books/vitamin-c/vitamin-c-sources-functions-sensing-and-analysis

Duncan, C.W., Huffman, C.F., Mitchell, R. Jr. and Reid, J.T. (1944). Symptom of scurvy observed in a herd of cattle. J. Dairy Sci. 24:636.

Eicher-Pruiett, S.D., Morrill, J.L., Blecha, F., Higgins, J.J., Anderson, N.V. and Reddy, P.G. (1992). Neutrophil and lymphocyte response to supplementation with vitamins C and E in young calves. J Dairy Sci. 75(6):1635-42. https://doi.org/10.3168/jds.S0022-0302(92)77920-X

Evan, T., Marcos, C.N., Ranilla, M.J. and Carro, M.D. (2020). In Vitro and In Situ Evaluation of Broccoli Wastes as Potential Feed for Ruminants. Animals. 10(1989): 1-14 doi:10.3390/ani10111989

Food and Nutrition Board. (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press.

Gaby, S.K. and Singh, V.N. (1991). Vitamin C. In Vitamin intake and health: a scientific review, Edited by: Gaby, SK, Bendich, A, Singh, VN and Machlin, L. 103–1043. New York: Marcel Dedder.

González-Montaña, J.R., Escalera-Valente, F., Alonso, A.J., Lomillos, J.M., Robles, R. and Alonso, M.E. (2020). Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update. Animals. 10(1855): 1-36. doi:10.3390/ani10101855

Grosso, G., Bei, R., Mistretta, A., Marventano, S., Calabrese, G., Masuelli, L., Giganti, M.G., Modesti, A., Galvano, F. and Gazzolo, D. (2013). Effects of Vitamin C on health: a review of evidence. Front Biosci. 18:1017-1029. doi: 10.2741/4160.

Haytowitz, D. (1995). Information from USDA’s nutrient data book. Journal of Nutrition. 125(7):1952-1955. doi: 10.1093/jn/125.7.1952.

Hemingway, D.C. (1991). Vitamin C in the prevention of neonatal calf diarrhoea. Can Vet J. 32(3):184.

Henzel, P. (2010). Nutrition and skin diseases in veterinary medicine. Clinics in Dermatology. 28(6): 686–693. https://doi.org/10.1016/j.clindermatol.2010.03.031

Hidiroglou, M. (1999). Technical Note: Forms and Route of Vitamin C Supplementation for Cows. J Dairy Sci. 82(8):1831–1833. DOI: 10.3168/jds.S0022-0302(99)75414-7

Hidiroglou, M., Ivan, M. and Batra, T.R. (1995). Concentration of vitamin C in plasma and milk of dairy cattle. Annales de Zootechnie.44(4): 399-402.

Hodnik, J.J., Ježek, J. and Starič, J. (2020). A review of vitamin D and its importance to the health of dairy cattle. Journal of Dairy Research. 87(S1):1-4 https://doi.org/10.1017/ S0022029920000424

Huang, A., Vita, J.A., Venema, R.C. and Keaney, J.F., Jr. (2000). Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J. Biol. Chem. 275(23): 17399–17406. DOI: 10.1074/jbc.M002248200

Hurley, W.L. and Doane, R.M. (1989). Recent Developments in the Roles of Vitamins and Minerals in Reproduction. J Dairy Sci. 72(3):784-804. DOI: 10.3168/jds.S0022-0302(89)79170-0

Hymøller, L., Jensen, S.K., Kaas, P. and Jakobsen, J. (2017). Physiological limit of the daily endogenous cholecalciferol synthesis from UV light in cattle. J Anim Physiol Anim Nutr (Berl). 101(2):215-221. doi: 10.1111/jpn.12540.

Inai, Y., Ohta, Y. and Nishikimi, M. 2003. The Whole Structure of the Human Nonfunctional L-Gulono-γ-Lactone Oxidase Gene - The Gene Responsible for Scurvy - And the Evolution of Repetitive Sequences Thereon. Journal of Nutritional Science and Vitaminology. 49(5):315-319. DOI: 10.3177/jnsv.49.315

Khan, R.U., Naz, S., Nikouzefat, Z., Selvaggi, M., Laudadio, V. and Tuvarelli, V. (2012). Effect of ascorbic acid in heat-stressed poultry. World's Poultry Science Journal. 68(3):477-490. DOI: 10.1017/S004393391200058X

Khayat, S., Fanaei, H. and Ghanbarzehi, A. (2017). Minerals in Pregnancy and Lactation: A Review Article. J. Clin. Diagn. Res. 11(9): QE01–QE05. doi: 10.7860/JCDR/2017/28485.10626

Kim, H.J., Lee, Y.J. and Eun, J.B. (2015). Effects of ultraviolet radiation on the physicochemical characteristics of Korean native cattle (Hanwoo) beef. J Korean Soc Appl Biol Chem 58, 149–156. https://doi.org/10.1007/s13765-015-0022-1

Kim, J.H., Mauad, L.L., Yang, C.J., Kim, S.H., Ha, J.K., Lee, W.S., Cho, K.K. and Lee, S.S. (2012). Hemato-biochemical and cortisol profile of Holistin growing-calves supplemented withvitamin C during summer season. Asian-Aust. J Anim. Sci. 25(3): 361-368. doi: 10.5713/ajas.2011.11438

Kleczkowski, M., Kluciński, W., Shaktur, A. and Sikora, J. (2005). Concentration of ascorbic acid in the blood of cows with subclinical mastitis. Pol J Vet Sci. 8(2):121-125.

Knight, C.A., Dutcher, R.A. and Guerrant, N.B. (1941). Utilization and excretion of ascorbic acid by the dairy cow. J. Dairy Sci. 24:567-577

Kolb, E. (1992). Recent findings of the significance of ascorbic acid for domestic animals and its use in veterinary medicine. Tierarztl Umsch. 47: 163–175.

Kolb, E., Wahren, M., Dobeleit, G. and Grundel, G. (1989). The content of ascorbic acids in different tissues of cattle, normally developed piglets, splay-legged piglets, adult swine and dogs. Ach Exp Vet Med. 43(3): 327–334.

Konings, E.J.M. (2006). Committee on Food Nutrition: Water-Soluble Vitamins. Journal of AOAC International. 86(1):147-149. DOI: 10.1093/jaoac/89.1.285

Kyureghian, G. and Flores, R.A. (2012). Meta-Analysis of Studies on Vitamin C Contents of Fresh and Processed Fruits and Vegetables. Journal of Food & Nutritional Disorders. 01(02): 1-7. DOI: 10.4172/2324-9323.1000101

Levine, M. (1986). New concepts in the biology and biochemistry of ascorbic acid. New Engl J Med. 314(14):892–902. DOI: 10.1056/NEJM198604033141407

Levine, M., Dhariwal, K.R., Welch, R.W., Wang, Y. and Park, J.B. (1995). Determination of optimal Vitamin C requirements in humans. Am J Clin Nutr. (6 Suppl):1347S-1356S. doi: 10.1093/ajcn/62.6.1347S.

Luck, M.R. and Jungclas, B. (1987). Catecholamines and ascorbic acid as stimulators of bovine ovarian oxytocin secretion. J Endocrinol. 114(3): 423–430. DOI: 10.1677/joe.0.1140423

Lundquist, N. S. and Phillips, P. H. (1942). Age related studies on ascorbic acid metabolism in animals. J. Dairy Sci. 25: 386–395.

Lykkesfeldt, J. and Tveden-Nyborg, P. (2019). Review The Pharmacokinetics of Vitamin C. Nutrients. 11(10): 1-20. doi:10.3390/nu11102412

Lykkesfeldt, J., Michels, A.J. and Frei, B. (2014). Vitamin C. Adv Nutr. 5(1): 16–18. doi: 10.3945/an.113.005157

Macan, A.M., Kraljević, T.G. and Raić-Malić, S. (2019). Therapeutic Perspective of Vitamin C and Its Derivatives. Antioxidants. 8(247): 1-36. https://doi.org/10.3390/antiox8080247

MacLeod, D.D., Ozimeck, L. and Kennelly, J.J. (2003). Supplemental vitamin C may enhance immune function in dairy cows. In: Proceedings of Western Canadian Dairy Seminar, URL, http://www.wcds.ca/proc/1996/wcd96227.htm

Macleod, D.D., Zhang, X., Kennelly, J. J. and Ozimek. L. (1999). Ascorbyl-2-polyphosphate as a source of ascorbic acid for dairy cattle. Milchwissenschaft. 54:123–126.

Maggini, S., Wintergerst, E.S., Beveridge, S. and Hornig, D.H. (2007). Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br. J. Nutr. 98 Suppl 1:S29-35. doi: 10.1017/S0007114507832971.

Marcos, C.N., Evan, T., Molina-Alcaide, E. and Carro, M.D. (2019). Nutritive Value of Tomato Pomace for Ruminants and Its Influence on In Vitro Methane Production. Animals 9(343): 1-15. doi:10.3390/ani9060343

Mardalena, L., Warly, E., Nurdin, W.S.N. Rusmana and Farizal. (2011). Milk Quality Of Dairy Goat By Giving Feed Supplement As Antioxidant Source. J. Indonesian Trop.Anim.Agric. 36(3): 205-211. DOI: https://doi.org/10.14710/jitaa.36.3.205-212

Martin, D.W. (1981). Harper’s Review of Biochemistry. 18thed,Los Altos,California 94022, Lange Medsical Publications

Matsui, T. (2012). Vitamin C Nutrition in Cattle, Asian Australasian Journal of Animal Sciences. 25(5): 597-605. DOI: 10.5713/ajas.2012.r.01

McDowell, L.R. (1989). Vitamin C. In: Vitamins in animal nutrition (Ed. L. R. McDowell). Academic Press, New York, USA. pp. 365-387.

Minka, N.S. and Ayo, J.O. (2012). Assessment of thermal load on transported goats administered with ascorbic acid during the hot-dry conditions. Int J Biometeorol. 56(2):333-41. doi: 10.1007/s00484-011-0437-2.

Mohamed, H.E., Mousa, H.M. and Byenen, A.C. (2004). Vitamin C status of Sudanese cattle and sheep. J. Biol. Sci.4 (6):778-779.

Nayyar, S. and Jindal, R. (2010). Essentiality of antioxidant vitamins for ruminants in relation to stress and reproduction. Iranian Journal of Veterinary Research, Shiraz University. 11(1): 1-9

Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N, and Yagi, K. (1994). Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. J Biol Chem. 269(18):13685-13688.

Nockels, C.F. (1988). Immunoenhancing vitamins for cattle. Agri-Practice 9:10-17

Opletalova, L. (1957). Investigations into the influence of daily yield on the vitamin content of milk. Z.Z.V.U. 12:63

Ostyakova, M.E., Sayapina, I.Y., Mandro, N.M., Trush, N.V., Gavrilov, Y.A., Gavrilova, G.A., Hibchenov, L.V. and Chubin, A.N. (2018). Morphological and Quantitative Characteristics of the Skin of Holstein Cattle in the Amur Region. International Journal of Engineering & Technology. 7 (3.5):78-82. DOI: 10.14419/ijet.v7i3.12.16135

Padang, S.A. dan Maliku, R.M. (2017). Penetapan Kadar Vitamin C Pada Buah Jambu Biji Merah (Psidium Guajava L.) Dengan Metode Titrasi Na-2,6 Dichlorophenol Indophenol (DCIP). Media Farmasi. 13(2): 1-6. DOI: https://doi.org/10.32382/mf.v13i2.879

Padayatty, S.J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.H., Chen, S., Corpe, C., Dutta, A., Dutta, S.K. and Levine, M. (2003). Review Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. Journal of the American College of Nutrition, 22(1): 18–35. DOI: 10.1080/07315724.2003.10719272

Padilla, L., Matsui, T., Ikeda, S., Kitagawa, M. and Yano, H. (2007). The effect of vitamin C supplementation on plasma concentration and urinary excretion of vitamin C in cattle. J Anim Sci. 85(12): 3367–3370. https://doi.org/10.2527/jas.2007-0060

Padilla, L., Matsui, T., Kamiya, Y., Kamiya, M., Tanaka, M. and Yano, H. (2006). Heat stress decreases plasma vitamin C concentration in lactating cows. Livest Sci. 101(1-3): 300–304. https://doi.org/10.1016/j.livprodsci.2005.12.002

Palludan, B. and Wegger, I. (1984). Plasma ascorbic acid in calves. In: Proceedings of Ascorbic Acid in Domestic Animal Workshop. Royal Danish Agric. Soc., Copenhagen. 1984 pp. 131-138.

Parsons, H.T. and Fry, S.C. (2012). Oxidation of dehydroascorbic acid and 2,3-diketogulonate under plant apoplastic conditions. Phytochemistry. 75 (2012):41-49. DOI: 10.1016/j.phytochem.2011.12.005

Pham-Huy, L.A., He, H. and Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci. 4(2): 89–96.

Pogge, D.J. and Hansen, S.L. (2013). Supplemental vitamin C improves marbling in feedlot cattle consuming high sulfur diets. J. Anim. Sci. 91(9):4303–4314 doi:10.2527/jas2012-5638

Ponec, M., Weerheim, A., Kempenaar, J., Mulder, A., Gooris, G.S., Bouwstra, J. and Mommaas, A.M. (1997). The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J. Invest. Dermatol. 109(3): 348–355. DOI: 10.1111/1523-1747.ep12336024

Pribyl, E. (1953). Diseases of young animals. SZN Praha 230 pp.

Pullar, J.M., Carr, A.C. and Vissers, M. (2017). The Roles of Vitamin C in Skin Health. Nutrients. 9(8): 1-27. https://doi.org/10.3390/nu9080866

Radostits, O.M. Gay, C.C., Hinchcliff, K.W. and Constable, P.D. (2007). Veterinary Medicine. Tenth ed., Saunders, Philadelphia.

Radostits, O.M., Blood, D.C. and Gay, C.C. 1994. Veterinary medicine: a textbook of diseases of cattle, sheep, pigs, goats and horses, London: ELBS with Bailliere Tindall.

Ranjan, R., Ranjan, A., Dhaliwal, G.S. and Patra, R.C. (2012). L-Ascorbic acid (vitamin C) supplementation to optimize health and reproduction in cattle. Veterinary Quarterly. 32 (3-4): 145-150, DOI: 10.1080/01652176.2012.734640

Raoofi, A., Asadi, F., Mardjanmehr, S.H. and Kazempoor, R. (2010). The effects of hypervitaminosis A in sheep following intramuscular administrations of vitamin A. Food and Chemical Toxicology. 48 (1): 193–195. doi:10.1016/j.fct.2009.09.038

Rejeb, M., Sadraoui, R. and Najar, T. (2016). Role of Vitamin C on Immune Function Under Heat Stress Condition in Dairy Cows. Asian Journal of Animal and Veterinary Advances. 11: 717-724. DOI: 10.3923/ajava.2016.717.724

Renner, E. (1983). Milk and dairy products in human nutrition, Munich,, Germany: WG Mott. University of Glessen.

Roth, J.A. and Kaeberle, M. L. (1982). Effect of glucocorticoids on the bovine immune system. J. Am. Vel Med. Assoc. 180(8):894-901

Sahinduran, S. and Albay, M.K. (2004). Supplemental Ascorbic Acid and Prevention of Neonatal Calf Diarrhoea. Acta Veterinaria Brno. 73(2): 222-224. DOI: 10.2754/avb200473020221

Salih, D.A., El Hussein, A.M. and Singla, L.D. (2015) Diagnostic approaches for tick-borne haemoparasitic diseases in livestock. J. Vet. Med. Anim.Health. 7(2):45-56. DOI: 10.5897/JVMAH2014.0345

Sarpooshi, H.R., Vaheb, M., Tabarayee, Y., Sabzevar, A.V. and Mortazavi, F. (2016). The effects of topical vitamin C solution on the necrotic tissue volume of burn wounds. Journal of Nursing and Midwifery Sciences. 3(3): 11-17. DOI: 10.18869/acadpub.jnms.3.3.11

Sato, P.H. and Udenfriend, S. (1978). Scurvy-prone animals including man, monkey, and guinea pig do not express the gene for gulonolactone oxidase. Arch. Biochem. Biophys. 187(1):158-162. https://doi.org/10.1016/0003-9861(78)90018-8

Saucedo, M.O., Rodríguez, S.H.S., Flores, C.F.A., Valenzuela, R.B. and Luna, M.A.L. (2019). Effects of ultraviolet radiation (UV) in domestic animals. Review. Rev Mex Cienc Pecu.10(2): 416-432. https://doi.org/10.22319/rmcp.v10i2.4648

Schlueter, A.K. and Johnston, C.S. (2011). Vitamin C: Overview and Update. Journal of Evidence-Based Complementary & Alternative Medicine. 16(1): 49-57. DOI: 10.1177/1533210110392951

Scott, D.W. (2007). Nutritional skin diseases. In: Scott DW, editor. Color atlas of farm animal dermatology. Malden, MA: Blackwell Publishing; 2007. pp. 83-86

Scott, W.D. (1988). Large Animal Dermatology. W.B. Saunders, Philadelphia.; 360.

Seifi, H.A., Mohri, M., Delaramy, M. and Harati, M. (2010). Effect of short term over-supplementation of ascorbic acid on hematology, serum biochemistry, and growth performance of neonatal dairy calves. Food Chem. Toxicol. 48(8-9): 2059–2062. DOI: 10.1016/j.fct.2010.05.006

Siener, R., Machaka, I., Alteheld, B., Bitterlich, N. and Metzner, C. (2020). Effect of Fat-Soluble Vitamins A, D, E and K on Vitamin Status and Metabolic Profile in Patients with Fat Malabsorption with and without Urolithiasis. Nutrients. 12(10):3110. https://doi.org/10.3390/nu12103110

Silva, R.G., La Scala, N. Jr. and Pocay, P.L.B. (2001). Transmission of Ultraviolet Radiation Through the Haircoat and the Skin of Cattle. Rev. bras. zootec. 30(6):1939-1947. https://doi.org/10.1590/S1516-35982001000700034.

Sivakumar, A.V.N., Singh, G. and Varshney, V.P. (2010). Antioxidants supplementation on acid base balance during heat stress in goats. Asian Austral J Anim Sci. 23(11): 1462–1468. DOI: 10.5713/ajas.2010.90471

Slavin, J.L. and Lloyd, B. (2012). Health Benefits of Fruits and Vegetables. Adv Nutr. 3(4): 506–516.doi: 10.3945/an.112.002154

Smirnoff, N. (2018). Ascorbic acid metabolism and functions: A comparison of plants and mammals. Free Radical Biology and Medicine. 122(2018): 116-129. https://doi.org/10.1016/j.freeradbiomed.2018.03.033

Smith,A., Primio,G. and Humphrey-Murto, S. (2011). Scurvy in the developed world. CMAJ. 183(11): E752–E755. doi: 10.1503/cmaj.091938

Tagliapietra, F., Cattani, M., Hansen, H.H., Bitantte, G. and Schiavon, S. (2020). High doses of vitamin E and vitamin C influence in vitro rumen microbial activity. Animal Feed Science and Technology. 183(183):210-214.DOI: 10.1016/j.anifeedsci.2013.05.010

Tayengwa, T. and Mapiye, C. (2018). Citrus and Winery Wastes: Promising Dietary Supplements for Sustainable Ruminant Animal Nutrition, Health, Production, and Meat Quality. Sustainability. 10(3718); 1-22. doi.3390/su10103718

Triutama, R.A., Rudiono, D. dan Adhianto, K. (2016). Effect Of Vitamin C Dosages On Cattle Body Weight Lost During Transportation From Lampung To Palembang Province. Jurnal Ilmiah Peternakan Terpadu 4(2): 134-139

Turner, C. and Mathiasson, L. (2000). Determination of vitamins A and E in milk powder using supercritical fluid extraction for sample clean‐up. Journal of Chromatography A, 874(2): 275–283. 10.1016/S0021-9673(00)00096-0

Tyler, P.J. and Cummins, K.A. (2003). Effect of dietary ascorbyl-2-phosphate on immune function after transport to a feeding facility. J Dairy Sci. 86(2):622-629. https://doi.org/10.3168/jds.S0022-0302(03)73640-6

Urban, K., Höhling, H.J., Lüttenberg, P., Szuwart, T. and Plate, U. (2012). An in vitro study of osteoblast vitality influenced by the vitamins C and E.J. Head Face Med. 8(25):1-10. doi: 10.1186/1746-160X-8-25.

Vissers, M.C.M. and Das, A.B. (2018). Review Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence. Front Physiol. 9(809):1-13. doi: 10.3389/fphys.2018.00809

Wang, K., Jiang, H., Li, W., Qiang, M., Dong, T. and Li, H. (2018). Role of Vitamin C in Skin Diseases. Front. Physiol. 9(819): 1-9. doi: 10.3389/fphys.2018.00819

Weiss, W.P. and Hogan, J.S. (2007). Effects of Dietary Vitamin C on Neutrophil Function and Responses to Intramammary Infusion of Lipopolysaccharide in Periparturient Dairy Cows. J. Dairy Sci. 90(2): 731-739. DOI:https://doi.org/10.3168/jds.S0022-0302(07)71557-6

Weiss, W.P. (2001). Effect of dietary vitamin C on concentrations of ascorbic acid in plasma and milk. J Dairy Sci. 84(10):2302-7. doi: 10.3168/jds.S0022-0302(01)74677-2.

Wieland, M., Mann, S., Gollnick, N.S., Majzoub-Altweck, M., Knubben-Schweizer, G. and Langenmayer, M.C. (2019). Alopecia in Belgian Blue crossbred calves: a case series. BMC Vet Res 15(411): 1-11. https://doi.org/10.1186/s12917-019-2140-1

Williams, L., McNeal, C. and Wilson, D.P. (2017). The Role of Fat Soluble Vitamins in Clinical Lipidology. Clin Med Rev Case Rep. 4 (187): 1-5. doi.org/10.23937/2378-3656/1410187

Zemene, Z. and Addis, M. (2012). Assessment of major factors that cause skin defects at Bahir Dar tannery, Ethiopia. Advances in Biological Research 6(5): 177-181.

Zhang, Y., Zhou, W., Yan, J., Liu, M., Zhou, Y , Shen, X., Ma, Y., Feng, X., Yang, J. and Li, G. (2018). A Review of the Extraction and Determination Methods of Thirteen Essential Vitamins to the Human Body: An Update from 2010. Molecules. 23(1484): 1-25. doi:10.3390/molecules23061484

DOI: https://doi.org/10.22146/jsv.71186