Pengaruh Pemberian Serum Albumin Manusia terhadap Kadar Albumin dalam Darah pada Anjing dengan status Hipoalbuminemia

Julita Dewitri Merthayasa; Putu Devi Devi Jayanti; Soedarmanto Indarjulianto; Ryan Hadi Permana; Nadia Liswardani Destinanda; Agustina Dwi Wijayanti

doi:10.22146/jsv.48513

Pengaruh Pemberian Serum Albumin Manusia terhadap Kadar Albumin dalam Darah pada Anjing dengan status Hipoalbuminemia

https://doi.org/10.22146/jsv.48513

Julita Dewitri Merthayasa^(1*), Putu Devi Devi Jayanti⁽²⁾, Soedarmanto Indarjulianto⁽³⁾, Ryan Hadi Permana⁽⁴⁾, Nadia Liswardani Destinanda⁽⁵⁾, Agustina Dwi Wijayanti⁽⁶⁾

(1) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(2) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(3) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(4) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(5) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(6) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Albumin consists of 50% of the total plasma protein and it is very important protein in the animal's body. Hypoalbuminemia can occurs due to various conditions, such as loss of protein nephropathy, loss of enteropathic proteins, chronic and acute diarrhea or heavy bleeding as well as malnutrition and malabsorption conditions. This study aims to determine the effect of human serum albumin 20% infusion to increase albumin blood level in hypoalbuminemia dogs. Animals used in this study were 5 dogs whose results showed the levels of albumin below normal limits or hypoalbuminemia. Dogs with hypoalbuminemia will be infused with human serum albumin (HSA) 20% through intravenous for ± 4 hours. Then, these dogs blood will be drawn days after infusion to screen for albumin levels. The results obtained in the form of examination data of albumin blood levels in the blood before and after infusion will be analyzed with paired T-test. The results showed an increase of albumin level significantly from an average of 1.98 ± 0.356 to 2.28 ± 0.257(P <0.05). This study shows the presence of human albumin serum through intravenous infusion was able to increase albumin levels in dogs with hypoalbuminemia.

Keywords

Dog; albumin; hipoalbuminemia; infusion; Human serum albumin 20%

Full Text:

PDF

References

Boldt, J. (2010). Use of albumin: an update. British journal of anaesthesia.104(3):276-84.

Call, D. (2005). The Use of Human Albumin Serum in Dogs. www. VetFolio.com. Internal medicine. Vol. 26 No. 12. Tanggal akses 1 november 2017.

Craft, E.M. dan Powell, L. L. 2012. The use of caninespesific albumin in dogs with septic peritonitis. Veterinary emergency and critical care, 22: 631-639.

Fasano M, Curry S, Terreno E, Galliano M, Fanali G, Narciso P, et al. (2005). The extraordinary ligand binding properties of human serum albumin. IUBMB Life; 57: 787-796.

Gatta, A., Verardo, A. & Bolognesi, M. (2012). 'Hipoalbuminemia', Internal and Emergency Medicine, Vol. 7, no. 3, pp. 193-199

Gerasimova, Y. V., Erchenko, I. A., Shakirov, M. M., Godovikova, T. S. 2008. Interaction of Human Serum Albumin and its Clinically Relevant Modification with Oligoribonucleatides. Bioorganic and Medicinal Chemistry Letters 18: 4511-4514.

Hackner, G. S. (2012). Plasma And Albumin Transfusions: Indications And Controversies. Cornell University Veterinary Specialists. Ikenoue, N., Saitsu, Y., Shimoda., Kokue, E. (2000). Disease-induced alteration in plasma drugbinding percentage in dogs. The Vet Quaterly.22:1-43-49.

Kaslow, J.E. (2010). Analysis od Serum Protein. Santa ANA ; 720 North Tustin Avenue Suite 104,CA. Latimer, K.S.; Edward, A. M.; Keith, W.P. (2003). Duncan and Prashe's Veterinary Laboratory Medicine: Clinical Phatology. US Iowa Press.

Lejon S, Frick IM, Björck L, Wikström M, Svensson S. (2004). Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin. J Biol Chem; 279: 42924-42928.

Martin, L.(2004). Human Albumin Solutions In The Critical Patient. Iveccs Proc:274-278

Mathews, K. (2008). The Therapeutic Use of 25% Human Serum Albumin in Critically Ill Dogs and Cats. Department of Clinical Studies, Emergency and Critical Care Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1H 6H8, Canada Mazzaferro EM, Rudloff E, Kirby R.(2002). The role of albumin replacement in the critically ill veterinary patient. J Vet Emerg Crit Care; 12:113–128.

Mosley, C.A.E. dan Mathews, K.A. 2005. The use of concentrated bovine serum albumin in canines (abstr). Vet Anesth Analg 32:14–15.

Peterson, M. E., dan Talcott, P. A. 2013. Small Animal Toxicology Third Edition. USA: Elsevier Saunders.

Salasia, S. I.O dan Hariono. Bambang. (2010). Patologi Klinik Veteriner Kasus Patologi Klinis. Yogyakarta: Samudra Biru. Hal. 6-7.

Tams, T. R. (2003). Handbook of small Animal nd Gastr oenterology, 2 Edition . Saunders. Hal. 289. Throop, J.L., Bingaman S, Huxley V. 2004. Differences between human and other mammalian albumins raises concerns over the use of human serum albumin in the dog. J Vet Intern Med;18(3):439

Tilley Lp, Smith Jr. Fwk. (2003). The 5-Minute Veterinary Consult: Canine And Feline, Ed 3. Philadelphia, Lippincott, Williams & Wilkins. Uhing, Michael R. (2004). The albumin controversy. Clinics In Perinatology.31: 475-488

Wijayanti AD, Dwi Cahyo BS. 2017. Hubungan Kadar Albumin dan Enrofloksasin dalam Plasma Anjing yang Diterapi Enrofloksasin. Acta Veterinaria Indonesiana. Vol. 5, No 1: 42-46

DOI: https://doi.org/10.22146/jsv.48513