Potensi Ekstrak Daun Sage (Salvia officinalis.L) sebagai anti-Streptococcus suis Penyebab Zoonotik Meningitis

Mitra Slipranata; Fajar Budi Lestari; Novra Arya Sandi; Siti Isrina Oktavia Salasia

doi:10.22146/jsv.27558

Potensi Ekstrak Daun Sage (Salvia officinalis.L) sebagai anti-Streptococcus suis Penyebab Zoonotik Meningitis

https://doi.org/10.22146/jsv.27558

Mitra Slipranata^(1*), Fajar Budi Lestari⁽²⁾, Novra Arya Sandi⁽³⁾, Siti Isrina Oktavia Salasia⁽⁴⁾

(1) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(2) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(3) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(4) Fakultas Kedokteran Hewan, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

The phenomenon of microbial resistance to an antibiotic or some kind of specific antibiotics (multi drugs resistance) greatly complicate the treatment process, one of which is Streptococcus suis (S. suis) which is known to cause meningitis in animals and humans. Today, with rising bacterial resistance to a wide range
of antibiotics, it takes an effort to assess the potential medicinal plants as an antibiotic that is appropriate and safe. Sage (Salvia officinalis.L) is reported to have antibacterial and fungicidal effect. Phenolic acids such as
salvin and ether monomethyl salvin which isolated from the sage thought to have antimicrobial activity against several bacterial strains. The purpose of this study was to prove the ability of sage leaf extract as an antibacterial
against S. suis causes streptococcal meningitis in vitro. In-vitro method used in this research through a two-stage dilution test and the diffusion test on Mueller Hinton Agar (MHA). S. suis isolates (code 225) were tested in vitro against 8 levels sage leaf extract concentration, ie a concentration of 1%, 3% 5%, 7%, 10%, 20%, 40% and 60%. The results of the test obtained by minimum inhibitory concentrations (MICs) and minimum sage known to potentially inhibit the growth of S. suis.

Keywords

Streptococcus suis; meningitis; zoonotic; Salvia officinalis. L; antibacterial

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References

Apua (Alliance For Prudent Use of Antibiotics). (2011). What is antibiotic resistance and why is it problem?. www.apua.org on 16-09-2011.

Baricevic, D., Sosa, S., Della, L.R., Tubaro, A., Simonovska, B., and Krasna, A.(200)1.Topical Anti- Inflammatory Activity of Salvia

officinalis L. leaves: The Relevance of Ursolic Acid. J.Ethno. pharmacol. 75:125–32.

Craig, J.W. (1999). Health-promoting properties of common herbs. Am. J. Clin. Nutr. 70: (suppl.):491-499.

Dragana, M.C., Branka, V.G., Jelena,K.V., Stankovic, S., and Draga, S. (2005). Comparative Study On The Antibacterial Activity Of Volatiles From Sage (Salvia Officinalis L.). Arch. Biol. Sci., Belgrade, 57 (3): 173-178.

Hembing, W.H.M. (1996). Tanaman Obat Berkhasiat Indonesia. Jilid 1. Pustaka Kartini. Jakarta: 1-2.

Karadi, R.V., Arpan, S., Pranav, P. and Parvez, A. (2011). Antimicrobial Activities of Musa paradisiaca and Cocos nucifera. International. Journal of Research in Pharmaceutical and Biomedical Sciences. 2: 264-267.

Kay, R., Cheng,A.F. and Tse C.Y. (1995). Streptococcus suis infection in Hong Kong. QJ Med.88 : 39-47.

Knezevic-Vukcevic, J., Vokovic_Gacic, B., Mitic, D., Beric, T., Nikolic, B. and Simic, D. (2001) Modulation of mutagenesis by terpenoids from sage (Salvia officinalis L.) World Conf. Med.and Arom. Plants. Abst. 0I/16.

Merdana, I.M. (2010) . Antibacterial Bioactivity Test of Traditional Herb. Laboratorium Farmasi Fakultas Kedokteran Hewan Universitas

Udayana. Vol. 3 No. 2.

Rizka, H. (2012). Uji Aktivitas Antibakteri Ekstrak Pelepah Dan Batang Tanaman Pisang Ambon (Musa Paradisiaca Var.Sapientum)

Terhadap Staphylococcus aureus. Laporan Hasil Karya Tulis Ilmiah. Program Pendidikan Sarjana Kedokteran Fakultas Kedokteran Universitas Diponegoro:12.

Stammati, A. Bonsi, P., Zucco, F., Moezelaar, R., Alakomi, H.L. and Von Wright, A. (1999). Toxicity of Selected Plant Volatiles in Microbial and Mammalian Short-term Assay. Food and Chem. Tox. 37: 813-.823.

Simic, D., Knezevic-Vukcevic, J. and Vukovic-Gacic, B. (2000). Prospects in using medicinal and aromatic plants in cancer prevention. Proc.of the First Conf. on Med. and Arom. Plants

South. Europ. Coun.: 97-104.

Suwandi, T.(2012). Pengembangan potensi antibakteri kelopak bunga Hibiscus sabdariffa L. (Rosela) Terhadap Streptococcus sanguinis penginduksi gingivitis menuju obat herbal terstandar. Jakarta. Disertasi Fakultas Kedokteran Gigi Universitas Indonesia.

DOI: https://doi.org/10.22146/jsv.27558