Infeksi Covid-19 pada Ibu Hamil dan Kejadian Anomali Kongenital: Scoping Review

https://doi.org/10.22146/jkr.74685

Patricia Alika Kurniawan(1*), Eugenia Maria Alodia Hartono(2), Shinta Prawitasari(3)

(1) Universitas Gadjah Mada
(2) Universitas Gadjah Mada
(3) Universitas Gadjah Mada
(*) Corresponding Author

Abstract


 

Background: Covid-19 (coronavirus disease 2019) is caused by Severe Acute Respiratory Coronavirus (SARS-CoV 2). Pregnant women have higher risk to get infection, including covid-19. Vertical transmission from mother to fetal does not seem to appear in covid-19, but further studies are still needed. Several cases have reported maternal vascular malperfusion and chronic histiocytic intervillositis with trophoblast necrosis in the placenta of mothers infected by covid-19, which can directly affect fetal development in the uterus. To date, little is known about the effect of SARS-CoV 2 infection in pregnancy. However, SARS-CoV 2 infection in the first trimester of pregnancy may have the potential to cause complication such as miscarriage and congenital anomaly.

Objective: This study was conducted to describe if there was any influence of covid-19 infection in pregnancy may lead up to the incidence of fetal congenital anomalies.

Method: This was a scoping review. Journals that suited inclusion and exclusion criteria were collected and analyzed. The inclusion criteria was journal discussing covid-19 in pregnancy correlated with fetal congenital anomaly. Exclusion criterias were journals not written in English or not full text. The journal was searched on  PubMed. Data was presented in the table.

Results and Discussion: A scoping review was carried out on 9 journals that matched the inclusion and exclusion criteria. A total of 6 journals did not show any association of congenital anomalies in infants born to mothers infected with covid-19. Three of the six journals did not find any congenital anomalies, while the other three journals consecutively stated that there was no relationship between maternal covid-19 infection and hearing loss, congenital heart disease, and neurodevelopmental delay (hearing loss and retinopathy of prematurity) in infants. One journal concluded that there was a significant increase in fine motor transient abnormalities. One journal concluded that eye abnormalities may be caused by fetomaternal transmission of covid-19 or an indirect effect of maternal covid-19 infection when optic tract development occurred. One journal was unable to conclude whether abnormal brain MRI results in 3 infants had any correlation with mother’s covid-19 infection during pregnancy. There were two journals that found placental insufficiency in subjects infected with covid-19.

Conclusion: The correlation between fetal congenital anomaly and maternal covid-19 infection has not been well established. Therefore, further investigation is still needed.

 

Keywords: Congenital Anomaly; Covid-19; Pregnancy


Keywords


Anomali Kongenital; Covid-19; Kehamilan

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References

  1. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed 2020;91(1):157-160.
  2. Sun J, He W-T, Wang L, Lai A, Ji X, Zhai X, Li G, Suchard MA, Tian J, Zhou J, et al. 2020. COVID-19: epidemiology, evolution, and cross-disciplinary perspectives. Trends Mol Med. 26(5):483–495.
  3. Su S, Wong G, Shi W, Liu J, Lai ACK, Zhou J, et al. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses. Trends Microbiol 2016;24:490-502.
  4. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. pregnancy : what obstetricians need to know. Am J Obstet Gynecol 2020;222(5):415-426.
  5. Holshue ML, DeBolt C, Lindquist S, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med 2020;382(10):929-936.
  6. Siston AM, Rasmussen SA, Honein MA, Fry AM, Seib K, Callaghan WM, et al. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States. JAMA 2010;303:1517–25.
  7. Mosby LG, Rasmussen SA, Jamieson DJ. 2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature. Am J Obstet Gynecol 2011;205:10–8.
  8. Ramsey PS, Ramin KD. Pneumonia in pregnancy. Obstet Gynecol Clin North Am 2001;28:553–69.
  9. Ajay Srivastava, Ramesh C. Gupta, Robin B. Doss, Rajiv Lall. (2021) Trace Minerals, Vitamins and Nutraceuticals in Prevention and Treatment of COVID-19. Journal of Dietary Supplements 0:1-35.
  10. Racicot K, Mor G. 2017. Risks associated with viral infections during pregnancy. J Clin Invest. 127(5):1591–1599.
  11. Poon LC, Yang H, Kapur A, et al. Global interim guidance on coronavirus disease 2019 (COVID19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. Int J Gynaecol Obstet 2020;149(3):273-286.
  12. Baergen RN, Heller SD. Placental pathology in covid-19 positive mothers: preliminary findings. Pediatr Dev Pathol. (2020) 23:177–80.
  13. Liu, Huan-Yu et al. “Transient Early Fine Motor Abnormalities in Infants Born to COVID-19 Mothers Are Associated With Placental Hypoxia and Ischemia.” Frontiers in pediatrics vol. 9 793561. 6 Jan. 2022
  14. Gao L, Ren J, Xu L, Ke X, Xiong L, Tian X, et al. . Placental pathology of the third trimester pregnant women from COVID-19. (2021) 16:8. 10.1186/s13000-021-01067-6.
  15. Poisson TM, Pierone G, Jr. Placental pathology and fetal demise at 35 weeks of gestation in a woman with SARS-CoV-2 infection: a case report. Case Rep Womens Health. (2021) 30:e00289. 10.1016/j.crwh.2021.e00289
  16. Schwartz DA, Baldewijns M, Benachi A, Bugatti M, Collins RRJ, De Luca D, et al. Chronic histiocytic intervillositis with trophoblast necrosis are risk factors associated with placental infection from coronavirus disease 2019 (COVID-19) and intrauterine maternal-fetal severe acute respiratory syndrome coronavirus 2 (S2ARS-CoV-2) transmission in liveborn and stillborn infants. Arch Pathol Lab Med. (2021) 145:517–28.
  17. Colson A, Sonveaux P, Debiève F, Sferruzzi-Perri NA. Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction. Hum Reprod Update. (2021) 27:531–69.
  18. Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, et al. . Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell. (2020) 181:1036–45.e9. 10.1016/j.cell.2020.04.026
  19. Camiolo M, Gauthier M, Kaminski N, Ray A, Wenzel ES. Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype. J Allergy Clin Immunol. (2020) 146:315–324.e7. 10.1016/j.jaci.2020.05.051
  20. Tanacan A, Yazihan N, Erol SA, Anuk AT, Yucel Yetiskin FD, Biriken D, et al. . The impact of COVID-19 infection on the cytokine profile of pregnant women: a prospective case-control study. Cytokine. (2021) 140:155431. 10.1016/j.cyto.2021.155431
  21. Dashraath P, Wong JLJ, Lim MXK, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol 2020;222(6):521-531.
  22. Shah PS, Diambomba Y, Acharya G, Morris SK, Bitnun A. Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. Acta Obstet Gynecol Scand 2020;99(5):565-568.



DOI: https://doi.org/10.22146/jkr.74685

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