Faktor-Faktor yang Meningkatkan Prognosis Fetal dan Maternal pada Kehamilan dengan Kanker Ovarium

https://doi.org/10.22146/jkr.51766

Efriyan Imantika(1*), Shinta Prawitasari(2), Diah Rumekti Hadiati(3)

(1) Departemen Obstetri dan Ginekologi, FK-KMK, UGM
(2) Departemen Obstetri dan Ginekologi, FK-KMK, UGM
(3) Departemen Obstetri dan Ginekologi, FK-KMK, UGM
(*) Corresponding Author

Abstract


Background: Pregnancy complicated by ovarian cancer presents relation between controlled growth in pregnancy and uncontrolled growth in cancer. The management of pregnancy illustrate conflict between optimal maternal therapy and fetal life for best prognosis at all. The incidence was low but it occured in reproductive age women and most found in the first pregnancy. It is important to analyze factors that improve the prognosis of pregnancy and appropiate management to prevent fetal and maternal morbidity and mortality.

 

Objectives: To analyze factor on pregnancy complicated by ovarian cancer that improve fetal and maternal prognosis

Methods: This is descriptive analytic study with cohort retrospective design using medical records of pregnancy patient complicated by ovarian cancer that underwent treatment at Sardjito Hospital Yogyakarta on 2010, January till 2017, December. All statistical analysis were done by statistic software for computer.

Results: There were 18 research subjek had been undergone treatment at Sardjito Hospital for 8 years. Factors on pregnancy related to prognosis of pregnancy complicated by ovarian cancer were late gestational age at the cancer diagnosis and epithelial histopathology type. That factors have better prognosis than early gestational age and non-epithelial histopathology clinically (p=0.18; CI 95% 0.4-104.2; OR 6,5) and (p=0.29; CI 95% 0.36-30.12; OR 3.28). Timing of surgery intervention improve prognosis of pregnancy statistically and clinically significant (p=0.02; OR=4.2).

 

Conclusion: Factors on pregnancy complicated by ovarian cancer that is late gestational age at the cancer diagnosis, epithelial histopathology type and timing of surgery intervention type II-III improved fetal and maternal prognosis. Best management of pregnancy lead to better prognosis.

Keywords: prognosis of pregnancy, ovarian cancer.

 


Keywords


prognosis of pregnancy; ovarian cancer;

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References

Laporan hasil riset kesehatan dasar (RISKERDAS) nasional 2017. Kehamilan dengan kanker ginekologi. Laporan penelitian, Badan Penelitian dan Pengembangan Kementrian Kesehatan Republik Indonesia

Graves CR, Parker L. 2008. Ovarian tumors complicating pregnancy. In: Te Linde’s Operative Gynecology 10th ed. Philadelphia: Lippincott & Wilkuns. Pp.842-50

Amant F, Calsteren KV, Halaska MJ, Bejinen J, Lagae L, Hanssens M et al. 2009. Gynecological cancer in pregnancy: Guidelines of an International consensus meeting. Int J of Gynecol Cancer: 19; 1-12

Haan KH, Kim MK, Kim HS, Chung HH, Song YS. 2013. Protective effect of Progesterone during pregnancy against ovarian cancer. J Cancer prev 18:113-122

Kwon YS, Mok JE, Lim KT, Lee IH, Kim TJ, Lee KH. 2010. Ovarian cancer during pregnancy: clinical and pregnancy outcome. J Korean Med Sci 25 (2): 230-234

Amneus M, Hoischneider CH. 2012. Cancer in Pregnancy, In: Gynecoloy and Oncology clinical practice & Surgical Atlas. United States: McGraw Hills. Pp.301-30

Chervenak FA, McCullough LB, Knapp RC, Caputo TA, Barber HRK. 2004. A clinically comprehensive ethical framework for offering and recommending cancer treatment before and during pregnancy. Cancer (100): 2

Aziz S, Shafi MI. 2005. Malignancy in pregnancy. Curr Obstet Gynecol. Vol. 15:414-6

Kodama M, Grubbs BH, Blake EA, Cahoon SS, Murakami R, Kimura T, Matsuo K. 2014. Fetomaternal outcomes of pregnancy complicated by ovarian malignant germ cell tumor: a systematic review of literature. Eur J Obstet & Gynecol and Reprod Biol: 181 pp.145-156

Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K. 2014. Fetomaternal outcomes of pregnancy complicated by ovarian sex cord tumor: a systematic review literature. Eur J of Obstet Gynecol and Reprod Biology. Vol 175; 1-7

Calsteren KV, Heyns L, Smet FD, Eycken LV, Gziri MM, Gemert WV, Halaska M et al. 2010. Cancer during pregnancy: An analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes. J of Clin Oncol: (28)4 pp.1-4

Morice P, Uzan C, Gouy S, Verschargen, Meder CH. 2012. Gynaecological cancers in pregnancy. The Lancet: 379

Chan JK, Tewari KS, Waller S, Cheung MK, Shin JY, Osann K, Kapp DS. 2008. The influence of conservative surgical practices for malignant ovarian germ cell tumors. J surg oncol: 98(2) pp.111-116

Mancari R, Tomasi N, Sarno MA, Azim HA, Franci D, Carinelli S, Biglia N, Colombo N, Peccatori FA. 2014. Treatment options for pregnant women with ovarian tumors. Int J Gyenecol Cancer (24): 967-972



DOI: https://doi.org/10.22146/jkr.51766

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