Pengaruh Psikokuratif terhadap Kadar VEGF-c, Kortisol dan Skor HADS Pasien Kanker Serviks Stadium Lanjut

https://doi.org/10.22146/jkr.50642

Soetrisno Soetrisno(1*), Sri Sulistyowati(2), Rubin Enhui Tjiang(3), Hari Wujoso(4), Hafi Nurinasari(5), Erindra Budi Cahyanto(6)

(1) Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta
(2) Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta
(3) Bagian Obstetri dan Ginekologi RSUD Dr. Moewardi Surakarta
(4) Bagian Forensik dan Medikolegal RSUD Dr. Moewardi Surakarta
(5) Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta
(6) Diploma Kebidanan Fakultas Kedokteran Universitas Sebelas Maret Surakarta
(*) Corresponding Author

Abstract


Background: Cancer diagnosis and therapy that causes chronic stress, its progression to depression  increase cortisol and VEGF-c levels in advanced cervical cancer patients

Objective: To  know the VEGF-c, cortisol and HADS level  in advanced stage cervical cancer patients who get Psychocurative intervention

 

Method : An experimental study of pretest – posttest controle group design in outpatient oncology clinic and ward of Doctor Moewardi General Hospital. Thirty subjects with advanced cervical cancer were randomly divided into 15 patients in the intervention group, and 15 in control. Psycho-curative intervention 4 times a month, 1 time a week, 60 minutes duration. Before and after intervention, each subject of the two groups was examined levels of VEGF-c, cortisol and HADS scores. Data obtained were analyzed by independent t test, Mann Whitney, Pair t and Wilcoxon with the 19th version of SPSS for Windows.

Result and Discussion: Average VEGF-c levels before intervention 9006.53 ± 2181.49, after intervention 5631.20 ± 2071.55, p <0.001. The mean cortisol level before intervention was 12.29 ± 4.36, after intervention 6.71 ± 3.88, p <0.001. The mean HADS Anxiety score before intervention was 14.13 ± 3.02, after intervention 8.47 ± 3.07, p <0.001. Mean Depression HADS scores before intervention 13.80 ± 3.21, after intervention 7.20 ± 2.70, p <0.001.

Conclusion : VEGF-c levels, cortisol, HADS anxiety scores and depression in patients with advanced cervical cancer decline after psychocurative intervention.

 

Keywords : Psychocurative; VEGF-c; Cortisol; HADS; Cervical cancer


Keywords


Psychocurative; VEGF-c; Cortisol; HADS; Cervical cancer

Full Text:

PDF


References

  1. Kemenkes RI. Situasi Penyakit Kanker. Buletin Jendela Data & Informasi Kesehatan, Semester 1. Kepala Pusat Data dan Informasi Kementerian Kesehatan RI. 2015: Jakarta
  2. Satin J.R, Linden W, Phillips M.J. Depression as a predictor of disease progression and mortality in cancer patients: a meta‑analysis. Cancer . Wiley online library. 2009; 115: 5349‑61
  3. Krebber AM, Buffart LM, Kleijn G, et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interview and self-report instruments. 2013; 23(2): 121-30
  4. Soetrisno. Ekspresi heatshock protein 60,70 dan Kortisol pada Persalinan Ibu Primigravida yang Mendapat Psikokuratif. Disertasi. 2009. Surabaya: Universitas Airlangga
  5. Smith MM, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncol. 2010; 6(12): 1863–81
  6. Magdalena F, Agata KF, Bogdan M, et al. Lymphangiogenesis in cervical cancer evaluated by expression of the VEGF-C gene in clinical stage IB-IIIB. Prz menopauzalny. 2015; 14(2): 112–117
  7. İzci F. İlgün AS, Fındıklı E, ÖzmenV. Psychiatric Symptoms and Psychosocial Problems in Patients with Breast Cancer. The journal of breast health AVES. 2016; 12(3):94–101.
  8. Villoria E and Lara L. Assessment of the Hospital Anxiety and Depression Scale for cancer patients. Revista médica de Chile. 2018; 146 (3): 300–7.
  9. Aydogan U, Doganer YC, Komurcu S, et al. Coping Attitudes of Cancer Patients and Their Caregivers and Quality of Life of Caregivers. Indian journal of palliative care. Wolters Kluwer - Medknow Publications. 2016; 22(2): 150 – 6.
  10. Shim E.J and Hahm B.J. Anxiety, helplessness/ hopelessness and “desire for hastened death” in Korean cancer patients. Eur J of Cancer Care. 2011; 20(3):395–402.
  11. Pinquart M, Duberstein P.R. Depression and cancer mortality: a meta‑analysis. Psychol Med. 2010; 40: 1797‑1810.
  12. Nakagawa JT, Espinosa MM, Barbieri M, et al. Cervical carcinoma: survival rate and prognostic factors in women in the state of Mato Grosso. Acta Paulista de Enfermagem. 2011; 24(5): 631–37.
  13. Staufenbiel S.M, Pennix B.W, Spijker A.T, et al. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoenocrinology. 2013; 38: 1220-35
  14. Iida M, Banno K, Yanokura M. Candidate biomarkers for cervical cancer intervention. Potential for clinical practice. Molecul and Clinical Oncol. 2014; 2: 647-55.
  15. Zhang L, Chen Q, Hu J, et al. Expression of HIF-2𝛼 and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance. Biomed Res Int. 2016.
  16. Cheng D,Liang B,Li Y. Serum Vascular Endothelial Growth Factor (VEGF-C) as a Diagnostic and Prognostic Marker in Patients with Ovarian Cancer. PLoS One, 2013; 8, (2).
  17. Djukanovic I, Carlsson J,Årestedt K. Is the Hospital Anxiety and Depression Scale (HADS) a valid measure in a general population 65–80 years old? A psychometric evaluation study. Health Qual Life Outcomes. 2017; 15(1): 193
  18. Widyadharma E, Rudy M, Adnyana O. Reability Indonesian Version Of The Hospital Anxiety And Depression Scale (HADS) Of Stroke Patients in Sanglah General Hospital Denpasar. Research gate.2015; 2: 1–23.
  19. Graeff F, Junior ZH. The hypothalamicpituitary - adrenal axis in anxiety and panic. Psychology & Neuroscience. 2010; 3: 3-8.
  20. Mehrabi E, Hajian S, Simbar M, et al. Coping response following a diagnosis of breast cancer : A systematic review. The Electronic physician. 2015; 7(8): 1575–83.
  21. Panduan Gangguan Depresi Mayor. Perhimpunan Dokter Spesialis Kedokteran Jiwa Indonesia. Jakarta. 2013: 5-8.
  22. Lutgendorf SK, Cole S, Costanzo E et al. Stress-Related Mediators Stimulate Vascular Endothelial Growth Factor Secretion by Two Ovarian Cancer Cell Lines. Clinical caner research. 2003; 9(1):4514–21
  23. Roberts MH, Fletcher RB, Merrick PL. 2014. The validity and clinical utility of the hospital anxiety and depression scale (HADS) with older adult New Zealanders. Int Psychogeriatr. 2014; 26(2): 325-33.



DOI: https://doi.org/10.22146/jkr.50642

Article Metrics

Abstract views : 1474 | views : 1573

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Kesehatan Reproduksi Indexed by:

 

 



SEKRETARIAT JURNAL KESEHATAN REPRODUKSI
Departemen Obstetri dan Ginekologi, FK-KMK, UGM/RS Dr. Sardjito
Jl. Kesehatan No. 1, Sekip Utara, Yogyakarta 55281
Tlp: (0274) 511329 / Faks: (0274) 544003
Email: jurnal.kesehatanreproduksi@ugm.ac.id
Cp: Dwi Astuti +6281802698043