Pengaruh Psikokuratif terhadap Kadar VEGF-c, Kortisol dan Skor HADS Pasien Kanker Serviks Stadium Lanjut

Soetrisno Soetrisno(1*), Sri Sulistyowati(2), Rubin Enhui Tjiang(3), Hari Wujoso(4), Hafi Nurinasari(5), Erindra Budi Cahyanto(6)

(1) Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta
(2) Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta
(3) Bagian Obstetri dan Ginekologi RSUD Dr. Moewardi Surakarta
(4) Bagian Forensik dan Medikolegal RSUD Dr. Moewardi Surakarta
(5) Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sebelas Maret/ RSUD Dr. Moewardi Surakarta
(6) Diploma Kebidanan Fakultas Kedokteran Universitas Sebelas Maret Surakarta
(*) Corresponding Author


Background: Cancer diagnosis and therapy that causes chronic stress, its progression to depression  increase cortisol and VEGF-c levels in advanced cervical cancer patients

Objective: To  know the VEGF-c, cortisol and HADS level  in advanced stage cervical cancer patients who get Psychocurative intervention


Method : An experimental study of pretest – posttest controle group design in outpatient oncology clinic and ward of Doctor Moewardi General Hospital. Thirty subjects with advanced cervical cancer were randomly divided into 15 patients in the intervention group, and 15 in control. Psycho-curative intervention 4 times a month, 1 time a week, 60 minutes duration. Before and after intervention, each subject of the two groups was examined levels of VEGF-c, cortisol and HADS scores. Data obtained were analyzed by independent t test, Mann Whitney, Pair t and Wilcoxon with the 19th version of SPSS for Windows.

Result and Discussion: Average VEGF-c levels before intervention 9006.53 ± 2181.49, after intervention 5631.20 ± 2071.55, p <0.001. The mean cortisol level before intervention was 12.29 ± 4.36, after intervention 6.71 ± 3.88, p <0.001. The mean HADS Anxiety score before intervention was 14.13 ± 3.02, after intervention 8.47 ± 3.07, p <0.001. Mean Depression HADS scores before intervention 13.80 ± 3.21, after intervention 7.20 ± 2.70, p <0.001.

Conclusion : VEGF-c levels, cortisol, HADS anxiety scores and depression in patients with advanced cervical cancer decline after psychocurative intervention.


Keywords : Psychocurative; VEGF-c; Cortisol; HADS; Cervical cancer


Psychocurative; VEGF-c; Cortisol; HADS; Cervical cancer

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