Psikoedukasi Dzikr Menurunkan Kadar Kortisol dan Meningkatkan Kadar IGG pada Ibu Primipara

Sri Wahyuni(1*), Anies Anies(2), Ariawan Soejoenoes(3), Suhartono Taat Putra(4)

(1) Poltekkes Kemenkes Surakarta
(2) Fakultas Kedokteran, Universitas Diponegoro
(3) Fakultas Kedokteran, Universitas Diponegoro
(4) Fakultas Kedokteran, Universitas Airlangga
(*) Corresponding Author


Background: Unstable emotions that are common during the perinatal period affect hormonal regulation and affect immunity. Research of psychoeducation dhikr be important was done to reduce perceived stress so that cortisol levels can be controlled hence IgG increases.

Purposes: to prove additional psychoeducation of dhikr in routine midwifery care more influential on decreasing cortisol and increasing IgG among primiparous women.

Methods: This study was an experimental study. A number of 24 participants as intervention group and a number of 23 participants as control group. Cortisol and IgG levels measured using ELIZA kits in the third trimester of pregnancy, the three days and tenth days after birth. Statistical test using General Linear Model and independent t test to compare Δ score.

Results: The result showed mean difference between groups on the end of interventions, cortisol 18.95, CI 95% (-13.42 – 51.33) and p value is 0.245. The difference of the IgG between groups 482.72, CI 95% (55,51 - 909,93) and p value is 0.028.

Conclusions: Additional psychoeducation of dhikr in routine midwifery care has more decrease Cortisol and increase IgG levels in primiparous women.


Keywords: Cortisol, Psychoeducation Dzikr, IgG, Primiparous


Cortisol; Psychoeducation Dzikr; IgG; Primiparous; Kortisol; Psikedukasi Dzikr; IgG; Primipara

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  1. Schetter CD, Tanner L, Angeles L. 2015. Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice. Curr Opin Psychiatry. 2015;25(2):141–8.

  2. Latendresse G, Ruiz RJ, Wong B. 2013. Psychological distress and SSRI use predict variation in inflammatory cytokines during pregnancy. Open J Obstet Gynecol. 2013;3(1A):184–91.

  3. Woods-Giscombé CL, Lobel M, Zimmer C, Wiley-Cené C, Corbie-Smith G. 2015. Whose Stress is Making Me Sick? Network Stress and Health in African American Women. Issues Ment Health Nurs.2015;36(9):710-7. doi: 10.3109/01612840.2015.1011759.

  4. O’Keane V, Lightman S, Patrick K, Marsh M, Papadopoulos AS, Pawlby S, et al. 2011. Changes in the maternal hypothalamic-pituitary-adrenal axis during the early puerperium may be related to the postpartum “blues.” J Neuroendocrinol. 2011;23(11):1149–55.

  5. de Rezende MG, Garcia-Leal C, de Figueiredo FP, Cavalli R de C, Spanghero MS, Barbieri MA, et al. 2016. Altered functioning of the HPA axis in depressed postpartum women. J Affect Disord. 2016;193:249–56.

  6. Seth S, Lewis AJ, Galbally M. 2016. Perinatal maternal depression and cortisol function in pregnancy and the postpartum period: a systematic literature review. BMC Pregnancy Childbirth. 2016;16(1):124.

  7. Urizar GG, Muñoz RF. 2011. Impact of a prenatal cognitive-behavioral stress management intervention on salivary cortisol levels in low-income mothers and their infants. Psychoneuroendocrinology. 2011;36(10):1480–94.

  8. Benfield RD, Newton ER, Tanner CJ. 2014. Cortisol as a biomarker of stress in term human labor: physiological and methodological issuses. Biol Res Nurs. 2014;16(1):64–71.

  9. Nepomnaschy PA, Welch KB, Mcconnell DS, Low BS, Strassmann BI, England BG. 2006. Cortisol levels and very early pregnancy loss in humans. PNAS. 2006;103(10):3938–42.

  10. Maria E, Reiche V, Odebrecht S, Nunes V, Morimoto HK. 2004. Review Stress , depression , the immune system, and cancer. 2004;5(October):617–25.

  11. Kendall-Tackett K. 2007. A new paradigm for depression in new mothers: the central role of inflammation and how breastfeeding and antiinflammatory treatments protect maternal mental health. Int Breastfeed J. 2007;2:6.

  12. Moser M, Leo O. 2000. Key concepts in immunology. Vaccine. 2010;28(SUPPL. 3):C2–13.

  13. Kresno, Siti B. Imunologi: Diagnosis dan Prosedur Laboratorium. 3rd ed. Jakarta: Balai Penerbit FKUI; 2000. 29-35 p.

  14. Haukioja A, Asunta M, Söderling E, Syrjänen S. 2014. Persistent oral human papillomavirus infection is associated with smoking and elevated salivary immunoglobulin G concentration. J Clin Virol. 2014;61(1):101–6.

  15. Callister LC, Khalaf I. 2010. Spirituality in childbearing women. J Perinat Educ. 2010;19(2):16–24.

  16. Mann JR, McKeown RE, Bacon J, Vesselinov R, Bush F. 2008. Do antenatal religious and spiritual factors impact the risk of postpartum depressive symptoms? J Womens Health (Larchmt). 2008;17(5):745–55.

  17. Akinloye O, Obikoya O, Jegede A, Oparinde D, Arowojolu A. 2013. Cortisol plays central role in biochemical changes during pregnancy. Int J Med Biomed Res. 2013;2(1):3–12.

  18. Faucette AN, Unger BL, Gonik B, Chen K. 2015. Maternal vaccination: Moving the science forward. Hum Reprod UPŻate. 2015;21(1):119–35.

  19. Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G, et al. 2009. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression. Metab Brain Dis. 2009;24(1):27–53.

  20. Corwin EJ, Ph D, Pajer K. 2008.The Psychoneuroimmunology of Postpartum Depression. J Women’s Heal. 2008;17(9).


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