Kadar nitric oxide serum berhubungan dengan tekanan darah pada dewasa muda dengan obesitas sentral: studi pertama di Indonesia

https://doi.org/10.22146/ijcn.70984

Nurhasanah Nurhasanah(1*), Imelda Tresia Pardede(2), Feriyandi Nauli(3), Istiyana Hayati(4), Fikri Roja Nasution(5), Angga Rizki Hermawan(6)

(1) KJFD Ilmu Gizi, Fakultas Kedokteran Universitas Riau, Pekanbaru / KJFD Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Riau/RSUD Arifin Achmad Provinsi Riau
(2) KJFD Ilmu Gizi, Fakultas Kedokteran Universitas Riau, Pekanbaru
(3) Program Studi Magister Imu Biomedis, Fakultas Kedokteran Universitas Diponegoro, Semarang / Departemen Pelayanan Medis Rumah Sakit Awal Bros Panam, Riau
(4) Program Studi Sarjana Kedokteran, Fakultas Kedokteran Universitas Riau, Pekanbaru
(5) Program Studi Sarjana Kedokteran, Fakultas Kedokteran Universitas Riau, Pekanbaru
(6) Program Studi Sarjana Kedokteran, Fakultas Kedokteran Universitas Riau, Pekanbaru
(*) Corresponding Author

Abstract


Serum nitric oxide levels are associated with blood pressure in young adults with central obesity

Background: Central obesity is a risk factor for hypertension, which is closely related to the presence of endothelial dysfunction and associated with levels of nitric oxide (NO).

Objective: This research was conducted to determine the relationship between NO and blood pressure (BP) in young adults with and without central obesity and also to compare the NO levels and BP between the two groups.

Methods: This cross-sectional study was conducted in Pekanbaru, Riau, Indonesia, with 80 young adult subjects aged 18-25 years by consecutive sampling, consisting of 40 subjects with central obesity (waist circumference (WC) ≥90 cm and ≥80 cm for men and women, respectively) and 40 subjects without central obesity (WC <90 cm and < 80 cm for men and women, respectively). Blood pressure was measured using a digital sphygmomanometer, and NO levels were measured using Griess methods. The statistical analysis begins with the normality test of the data, normal data was analyzed with the Pearson correlation test, and abnormal data was analyzed with the Spearman test. Differences in the levels of NO, systolic blood pressure (TDS), and diastolic blood pressure (TDD) between groups was analyzed with the Mann-Whitney-U test.

Results: Most of the subjects had high NO levels (66.3%). NO levels had a positively significant relationship with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in total subjects (r = 0.503, p <0.05; r= 0.289, p<0.05, respectively) and with SBP in subjects with central obesity (r = 0.324, p <0.05) but there was no significant relationship in normal subjects. There is a significant difference between serum NO levels, SBP, and DBP between subjects with central obesity and normal subjects (p <0.05).

Conclusion: NO levels have a positive significant relationship with SBP and DBP in total subjects and with SBP in young adults with central obesity.


Keywords


blood pressure; central obesity; nitric oxide; young adults

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References

  1. Ellulu M, Abed Y, Rahmat A, Ranneh Y, Ali F. Epidemiology of obesity in developing countries: challenges and prevention. Glob Epidemic Obes. 2014;2(2). doi: 10.7243/2052-5966-2-2
  2. WHO. Obesity and overweight. [series online] 2020 [cited 2021 Feb 28]. Available from: URL: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  3. Kementerian Kesehatan Republik Indonesia. Hasil utama riset kesehatan dasar 2018. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018.
  4. Sundari E, Masdar H, Rosdianan D. Angka kejadian obesitas sentral pada masyarakat Kota Pekanbaru. J Online Mhs Fak Kedokt Univ Riau [series online] 2015;2(2):1–16 [cited 2022 Feb 28]. Available from: URL: https://jom.unri.ac.id/index.php/JOMFDOK/article/view/4866
  5. Wirdhatul J, Bebasari E, Ernalia Y. Profil status gizi mahasiswa Fakultas Kedokteran Universitas Riau angkatan 2012 dan 2013 berdasarkan indeks massa tubuh, waist hip ratio dan lingkar pinggang. J Online Mhs Fak Kedokt Univ Riau [series online] 2015;2(1):1–7 [cited 2022 Feb 28]. Available from: URL: https://jom.unri.ac.id/index.php/JOMFDOK/article/view/4187
  6. Shuster A, Patlas M, Pinthus JH, Mourtzakis M. The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis. Br J Radiol. 2012;85(1009):1–10. doi: 10.1259/bjr/38447238
  7. Oliveira-Paula G, Lacchini R, Tanus-Santos J. Inducible nitric oxide synthase as a ossible target in hypertension. Curr Drug Targets. 2014;15(2):164–74. doi: 10.2174/13894501113146660227
  8. Brandes RP. Endothelial dysfunction and hypertension. Hypertension. 2014;64(5):924–8. doi: 10.1161/HYPERTENSIONAHA.114.03575
  9. Correia-Costa L, Sousa T, Morato M, Cosme D, Afonso J, Areias JC, et al. Oxidative stress and nitric oxide are increased in obese children and correlate with cardiometabolic risk and renal function. Br J Nutr. 2016;116(5):805–15. doi: 10.1017/S0007114516002804
  10. Chen J, Ye Z, Wang X, Chang J, Yang M, Zhong H, et al. Nitric oxide bioavailability dysfunction involves in atherosclerosis. Biomed Pharmacother. 2018;97:423–8. doi: 10.1016/j.biopha.2017.10.122
  11. Ghasemi A, Zahediasl S, Azizi F. Elevated nitric oxide metabolites are associated with obesity in women. Arch Iran Med. 2013;16(9):521–5.
  12. Habib S, Ali A. Role of nitric oxide in sports nutrition. In: Nutrition and Enhanced Sports Performance. Second Edi. Elsevier; 2019. doi: 10.1016/B978-0-12-813922-6.00027-8
  13. Ghasemi A, Jeddi S. Anti-obesity and anti-diabetic effects of nitrate and nitrite. Nitric Oxide. 2017;70:9–24. doi: 10.1016/j.niox.2017.08.003
  14. Bahadoran Z, Mirmiran P, Jeddi S, Momenan AA, Azizi F, Ghasemi A. The nitrate-nitrite-nitric oxide pathway: findings from 20 years of the Tehran lipid and glucose study. Int J Endocrinol Metab. 2018;16(4 Suppl):e84775. doi: 10.5812/ijem.84775
  15. Bahadoran Z, Mirmiran P, Jeddi S, Carlström M, Azizi F, Ghasemi A. Circulating markers of nitric oxide homeostasis and cardiometabolic diseases: insights from population-based studies. Free Radic Res. 2019;53(4):359–76. doi: 10.1080/10715762.2019.1587168
  16. Hsu C, Lu P, Lo M, Lin I, Tain Y. The association between nitric oxide pathway, blood pressure abnormalities, and cardiovascular risk profile in pediatric chronic kidney disease. Int J Mol Sci. 2019;20(21):5301. doi: 10.3390/ijms20215301
  17. Ghasemi A, Zahediasl S, Syedmoradi L, Azizi F. Association between serum nitric oxide metabolites and hypertension in a general population. Int Angiol. 2011;30(4):380–7.
  18. Choi JW, Pai SH, Kim SK, Ito M, Park CS, Cha YN. Increases in nitric oxide concentrations correlate strongly with body fat in obese humans. Clin Chem. 2001;47(6):1106–9.
  19. Gruber H-J, Mayer C, Mangge H, Fauler G, Grandits N, Wilders-Truschnig M. Obesity reduces the bioavailability of nitric oxide in juveniles. Int J Obes. 2008;32(5):826–31. doi: 10.1038/sj.ijo.0803795
  20. WHO/IASO/IOTF. The Asia-Pacific perspective : redefining obesity and its treatment [series online] 2000 [cited 2022 Feb 28]. Available from: URL: https://apps.who.int/iris/handle/10665/206936
  21. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206–52. doi: 10.1161/01.HYP.0000107251.49515.c2
  22. Romitelli F, Santini SA, Chierici E, Pitocco D, Tavazzi B, Amorini AM, et al. Comparison of nitrite/nitrate concentration in human plasma and serum samples measured by the enzymatic batch Griess assay, ion-pairing HPLC and ion-trap GC–MS: the importance of a correct removal of proteins in the Griess assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;851(1–2):257–67. doi: 10.1016/j.jchromb.2007.02.003
  23. Ghasemi A, Zahediasl S, Azizi F. High serum nitric oxide metabolites and incident metabolic syndrome. Scand J Clin Lab Invest. 2012;72(7):523–30. doi: 10.3109/00365513.2012.701322
  24. Higashino H, Miya H, Mukai H, Miya Y. Serum nitric oxide metabolite (NO(x)) levels in hypertensive patients at rest: a comparison of age, gender, blood pressure and complications using normotensive controls. Clin Exp Pharmacol Physiol. 2007;34(8):725–31. doi: 10.1111/j.1440-1681.2007.04617.x
  25. Foroumandi E, Alizadeh M, Kheirouri S, Asghari Jafarabadi M. Exploring the role of body mass index in relationship of serum nitric oxide and advanced glycation end products in apparently healthy subjects. PLoS One. 2019;14(3):e0213307. doi: 10.1371/journal.pone.0213307
  26. Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, Megías-Vericat J, Tortajada-Girbés M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis. 2011;215(2):475–80. doi: 10.1016/j.atherosclerosis.2010.12.035
  27. Sansbury BE, Hill BG. Regulation of obesity and insulin resistance by nitric oxide. Free Radic Biol Med. 2014;73:383–99. doi: 10.1016/j.freeradbiomed.2014.05.016
  28. Nguyen Duc N, Bui Van N, Vo HL, Nam K Do, Si Anh HN, Minh HT, et al. Impact of body mass index and waist circumference on blood pressure: a cross-sectional survey in a population living in the Vietnam northern mountainous. Diabetes Metab Syndr. 2019;13(2):1399–404. doi: 10.1016/j.dsx.2019.02.015
  29. Astuti AAAFD, Widyastuti N, Kusumastuti AC. Hubungan beberapa indikator obesitas dengan tekanan darah wanita dewasa muda. J Nutr Coll. 2017;6(3):219. doi: 10.14710/jnc.v6i3.16913



DOI: https://doi.org/10.22146/ijcn.70984

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