Korelasi persentase lemak tubuh dengan kadar adipsin pada premenopause

https://doi.org/10.22146/ijcn.33401

Rahmani Welan(1*), Gusti Revilla(2), Desmawati Desmawati(3)

(1) Program Studi Magister Ilmu Biomedik, Fakultas Kedokteran Universitas Andalas
(2) Bagian Anatomi, Fakultas Kedokteran Universitas Andalas
(3) Bagian Ilmu Gizi, Fakultas Kedokteran Universitas Andalas
(*) Corresponding Author

Abstract


Background: One of the conditions on premenopausal period is the increase in body fat, among which are caused by levels of the fluctuating estrogen hormone. Increase fat affects the body fat percentage and adipsin levels. Adipsin plays a role in the stimulation of insulin secretion by producing C3a, in which C3AR1 (C3a Receptor 1) fragments interact with beta cells to secrete insulin.

Objective: The purpose of this study is to determine correlation of body fat percentage with adipsin levels on premenopause.

Design: This was an analytical study with cross-sectional design. Body fat percentage was obtained by examination using Bioelectrical Impedance Analysis (BIA). Venous blood was taken at the mediana cubiti area used for serum adipsin levels. Adipsin levels were analyzed by Enzyme-linked Immunosorbent Assay (ELISA) technique.

Results: The mean of body fat percentage on premenopausal was 36,18 ± 8,35%. The mean of adipsin levels on premenopausal was 117,05 ± 87,93 ng/ml. Result of Pearson test analysis got value r = 0,632 and value p = 0.0005 (p <0,05).

Conclusions: There is a positive significant correlation between the percentage of body fat with adipsin levels on premenopause.


Keywords


adipsin; body fat percentage; premenopause

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References

  1. Badan Pusat Statistik. Penduduk menurut kelompok umur dan jenis kelamin. [series online] 2010 [cited 2017 Mei 14]. Available from: URL: http://www.bps.go.id
  2. Soares CDN, Lee SC. The perimenopause, depresive disorder, and hormonal variability. Sao Paulo Med J 2001;119(2):78-83.
  3. BPS Kota Padang. Padang dalam angka 2015. [series online] 2016 [cited 2017 Mei 14]. Available from: URL: http://padangkota.bps.go.id
  4. Anwar M, Ali B, Prajitno P (eds). Ilmu kandungan. Jakarta: PT Bina Pustaka Sarwono Prawirohardjo; 2011.
  5. Budiharjo S, Mansyur R, Djoko P. Pengaruh latihan fisik intensitas sedang terhadap persentase lemak badan wanita lanjut usia. Berkala Ilmu Kedokteran 2004;36(4):195-200.
  6. Setiawan M. Nutrisi kedelai pada obesitas dan dismetabolik sindrom. Saintika Medika 2010;6(2):1-8.
  7. Davis SR, Camil CB, Peter C, Lumsden MA, Rossella EN, Paulina V, et al. Understanding weight gain at menopause. Climacteric 2012;15(5):419-29.
  8. Putri SR, Dian IA. Obesitas sebagai faktor resiko peningkatan kadar trigliserida. Majority 2015;4(9):78-82.
  9. Choy LN, Barry SR, Bruce MS. Adipsin and an endogenous pathway of complement from adipose cells. J  Biol Chem 1992;267(18):12736-41.
  10. Pomeroy C, J Mitchell, E Eckert, N Raymond, R Crosby, AP Dalmasso. Effect of body weight and caloric restriction on serum complement proteins, including factor D/adipsin: studies in anorexia nervosa and obesity. Clin Exp Immunol 1997;108(3):507-15.
  11. Flint E, Stevens C, Amanda S. Association between active commuting, body fat, and body mass index: population based, cross sectional study in The United Kingdom. BMJ 2014;349:1-9.
  12. Azizi M, Vahid T, Naser B. The effect of aerobic exercise training on β-cell function and circulating levels of adipsin in community of obese women with type 2 diabetes mellitus. Int J Diabetes Dev Ctries 2017;37(3):298-304
  13. Anjos LAD, Fabiana DCT, Vivian W, Mauricio TLV, Scott BG. Body fat pecentage and body mass index in a probability sample of an adult urban population in Brazil. Cad Saude Publica 2013; 29(1):73-81.
  14. Zhao D, Yonglan L, Lianbin Z, Keli Y. Brief communication: body mass index, body adiposity, and percent body fat in Asians. Am J Phys Anthropol 2013:1- 6. 
  15. Zeng Q, Sheng YD, Xiao NS, Jing X, Yi C. Percent body fat is a better predictor risk factors than body mass index. Braz J Med Biol Res 2012;45(7):591-600.
  16. Ito H, Ohshima A, Ohto N, Tsuzuki M, Takao K, Hijii C, Tanaka  H, Nishioka K. Relation between body composition and age in healthy Japanese subject. Eur J Clin Nutr 2001;55(6):462-7.
  17. Meeuwsen S, Gerard WH, Marinos E. The relationship between BMI and percent body fat, measured by bioelectrical impedance, in a large adult sample is curvilinear and influenced by age and sex. Clin Nutr 2010;29:560-6.
  18. Al-Daghri NM, Abdulrahman SMAA, Hanan A, Sobhy MY, Naji Al, Sudhesh K, et al. Serum cytokine, chemokine, and hormone levels in Saudi adults with pre-diabetes: a one-year prospective study. Int J Clin Exp Pathol 2015;8(9):11587-93.
  19. Cianflone K, Zhunan X, Lan YC. Critical review of acylation-stimulating protein physiology in human and rodent. Biochim Biophys Acta 2003;1609(2):127-43.
  20. Avram, AS, Mathew MA, William DJ. Subcutaneous fat in normal and diseased state: 2. Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 2005;53:671-83.
  21. Badman, MK, Jeffrey SF. The adipocyte as an active participant in energy balance and metabolisme. Gastroenterology 2007;132(6): 2103-15.
  22. Kloting N, Matthias B. Adipocyte dysfunction, inflamation, and metabolic syndrome. Rev Endocr Metab Disord 2014;15(4):277-87.
  23. Aguilar-Valles, A, Wataru I, Christoph R, Giamal NL. Obesity, adipokines, and neuroinflamation. Neuropharmacology 2015;96:124-34.
  24. Vasilenko MA, Kirienkova EV, Daria AS, Pavel AZ, Miroyuk NI, Larisa SL. The role of production of adipsin and leptin in The development of insulin resistance in patients with abdominal obesity. Dokl Biochem Biophys 2017;475(1):271-6.
  25. Elekofehinti OO, Oluwamodupe CE, Jean PK, Oluwaseun BA, Isaac GA. Saponins as adipokine modulator : a possible therapeutic intervention for type 2 diabetes. World J Diabetes 2017;8(7):337-45.
  26. Sramkova M, Michaela D, Jana V, Josef V, Petr M, Olga B, et al. Levels of adipokines and some steroids during the menstrual cycle. Physiol Res 2015;64(2):147-54.
  27. Ukkola O, Monique C, Tremblay A, Claude B. Genetic variation at the adipsin locus and response to long-term overfeeding. Eur J Clin Nutr 2003;57(9):1073-8.
  28. Bienertova-Vasku J, Jan N, Filip Z, Martin F, Sona H, Anns V, et al. The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese central European population. Eat Behav 2014;15(2):244-51.
  29. Mavri A, Mojca S, Michael K, Jozica TS, Margarethe G, Bernard RB. Impact of adipose tissue on plasma plasminogen activator inhibitor-1 in dieting obese omen. Arterioscler Thromb Vasc Biol 1999;19:1582-7.
  30. Rahmawati A. Mekanisme terjadinya inflamasi dan stres oksidatif pada Obesitas. El-Hayah 2014;5(1):1-8.
  31. Wangko WS, Sunny W. Adipogenesis tumbuh kembang adiposit. Jurnal Biomedik 2010;2(3):153-61.
  32. Susantiningsih T. Obesitas dan stres oksidatif. JuKe Unila 2015;5(9):89-93.
  33. Baas T. Adipsin meets β cells. SciBX2014;7(30):1-3.



DOI: https://doi.org/10.22146/ijcn.33401

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