Perubahan kadar hemoglobin akibat terapi kurkuminoid ekstrak rimpang kunyit dibandingkan natrium diklofenak pada penderita osteoartritis

https://doi.org/10.22146/ijcn.17756

Nyoman Kertia(1*), Ahmad Husain Asdie(2), Wasilah Rochmah(3), Marsetyawan Marsetyawan(4)

(1) Divisi Rematologi, Bagian Penyakit Dalam Fakultas Kedokteran Universitas Gadjah Mada/RSUP Dr. Sardjito
(2) Divisi Endokrinologi, Metabolisme, dan Diabetes, Bagian Penyakit Dalam Fakultas Kedokteran Universitas Gadjah Mada/rsup Dr. Sardjito
(3) Divisi Geriatri, Bagian Penyakit Dalam Fakultas Kedokteran Universitas Gadjah Mada/RSUP Dr. Sardjito
(4) Bagian Histologi dan Biologi Sel, Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Background: In general, patients with osteoarthritis require long live treatments, especially anti-infammatory drugs. Non steroidal anti infammatory drugs are mostly follow by some side effects such as dyspepsia and gastrointestinal bleeding. The use of natural medicine for rheumatic diseases have commonly been practiced worldwide.

Objectives: To learn the changes of hemoglobin level due to treatment with curcuminoid from Curcuma domestica Val. rhizome extract compared to diclofenac sodium as anti-infammatory agent for the treatment of osteoarthritis.

Methods: This research is a prospective randomized open end blinded evaluations (PROBE). Patients treated with 30 mg curcuminoid from Curcuma domestica Val. rhizome extract or 25 mg diclofenac sodium three times daily for 4 weeks respectively.The hemoglobin level was checked before and after treatment. 

Results: A total of 80 patients with knee osteoarthritis participated in this study. There was no signifcant difference in the frequency of sex, educational level, duration of suffering, percentage of co-morbidities in both groups. There was no signifcant different of hemoglobin level before treatment between both treatment group. The hemoglobin level was increase signifcantly in curcuminoid treatment groups while no signifcant change in diclofenac group. Treatment with curcuminoid increasing the hemoglobin level signifcantly compare to diclofenac sodium (p=0.03).

Conclusion: Treatment with curcuminoid from Curcuma domestica Val. rhizome increasing the hemoglobin level signifcantly compare to diclofenac sodium treatment for osteoarthritis.


Keywords


change of hemoglobin concentration; curcuminoid; diclofenac sodium; osteoarthritis

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References

Psaty BM, Furberg CD. COX-2 inhibitors - lessons in drug safety. N Engl J Med 2005; 352:1133-5.

Timmerman H. New perspective for anti-inflammatory drugs in Pramono, S (ed). Curcumin pharmacochemistry. Yogyakarta: Aditya Media; 1995.

Alvarez-Soria MA, Largo R, Sanchez-Pernaute O, Calvo E, Egido J, Herrero-Beaumont G, Santillana J, Hernandez M. Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac. Ann Rheum Dis 2006; 65(8):998-1005.

Kalim H, Hidayat M, Loekito RM, Hanafi M, Tjahjono CT, Iskandar A, Kusworini H. Masalah penyakit reumatik di masyarakat Malang. Dalam: Kalim H, Kusworini H, Hidayat M, (eds). Naskah Seminar dan Workshop Osteoartritis. Malang: Fakultas Kedokteran Universitas Brawijaya; 1996. 5-10.

Sampurno. Informasi temu lawak Indonesia. Jakarta: Badan Pengawas Obat dan Makanan Republik Indonesia; 2004.

Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin, cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 2004; 44(2):97-111.

Santoso B, Warih B, Pramono S. Uji klinik pendahuluan ekstrak perasan kunyit sebagai obat gastritis (laporan penelitian). Yogyakarta: Pusat Penelitian Obat Tradisional Universitas Gadjah Mada; 1991.

Pramono S. Standarisasi kadar kurkumin dalam ekstrak kunyit dengan aktivitas anti ulkus lambung. Dalam: Wiryowidagdo S, Darise M, Sudirman I, Wahyudin E, Wunas J, (eds). Simposium Penelitian Tumbuhan Obat VII. Ujung Pandang; 1993. 86-90.

Santosa MH, Dyatmiko W, Soemarto R, Adi P, Zaini NC. Efficacy of standardized temu lawak extract capsule on chronic hepatitis patients (abstract). International Symposium on Curcumin Pharmacochemistry (ISCP). Yogyakarta; 1995.

Hadi S. Khasiat fitofarmaka pada hepatitis. Simposium Hepatitis.Yogyakarta; 1996.

Huang MT, Ma W, Lou YR, Lu YP, Chang R, Newmark H, Conney AH. Inhibitory effect of curcumin on tumorigenesis in mice. In Pramono S, (ed). Curcumin pharmacochemistry. Yogyakarta: Aditya Media; 1995. 47-63.

Kertia N, Danang, Broto R, Rahardjo P, Asdie AH. Increase quality of service for patients with osteoarthritis by using the combination of curcuminoid and curcumin’s atsiri oil. In Abstract of 9 Associations for Rheumatology Congress. Beijing; 2000.

Kertia N, Neneng R. Perbandingan efek samping pada hati dan saluran cerna antara ekstrak kunyit dengan natrium diklofenak pada penderita osteoartritis. Yogyakarta: Laporan Penelitian, Fakultas Kedokteran Universitas Gadjah Mada; 2004.

Denny SD, Kuchibhatla MN, Cohen HJ. Impact of anemia on mortality, cognition and function in community- dwelling elderly. Am J Med 2006; 119:327-34.

Lemeshow S, Hosmer DW, Klar J, Lwanga SK. Adequacy of sample size in health studies. (terjemahan) Pramono D. Yogyakarta: Gadjah Mada University Press; 1997.

Kim DC, Kim SH, Choi BH, Baek N, Kim D, Kim MJ. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol Pharm Bull 2005; 28(12): 2220-4.

Kundu P, De R, Pal I, Mukhopadhyay AK, Saha DR, Swarnakar S. Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of helicobacter pylori infection in cultured cells and mice. Plos One 2010; 6(1): e16306. doi:10.1371.

Tseng CC, Wolfe MM. Nonsteroidal anti-inflamatory drugs. Med Clin N Am 2000; 84:1329-44.

Kertia N. Peran preferentially selective COX inhibitor dalam pengobatan nyeri reumatik. Dalam Simposium Osteoporosis, Nyeri Reumatik, dan Stroke. Yogyakarta: Fakultas Kedokteran Universitas Gadjah Mada; 2004. 3-14.

Aggarwal BA, Bhatt ID, Ichikawa H, Ahn KS, Sethi G, Sandur SK. Curcumin-biological and medicinal properties [serial online] 2006 [cited 2011 Feb 24]. Available from:URL: http://www.indsaff.com/10 Curcumin biological. pdf.

Daniel L, Simmons, Regina M, Botting, Timothy HL A. Cycloxygenase isozyme: the biology of prostaglandin synthesis and inhibitiom. Pharmacol Rev 2004; 56(3):387-437.



DOI: https://doi.org/10.22146/ijcn.17756

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