Hubungan kadar serum albumin dengan kejadian morbiditas dan mortalitas pada pasien penyakit ginjal kronik dengan hemodialisis di RS Dr. Sardjito Yogyakarta

La Banudi(1*), Ahmad Husain Asdie(2), Susetyowati Susetyowati(3)

(1) Politeknik Kesehatan Kendari
(2) Bagian Penyakit Dalam RSUP Dr. Sardjito Yogyakarta/Fakultas Kedokteran Universitas Gadjah Mada
(3) Program Studi Ilmu Gizi Kesehatan Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author


Background: Chronic kidney disease is a characterized by decreasing kidney function with creatine clearance test <15 mL/minute. At such condition toxic in the body accumulates so that dialysis is needed to eliminate it. Blood albumin serum level may indicate nutrition status and is closely related to morbidity and mortality of hemodialysis patients.

Objective: To find out association between albumin serum level and occurrence of morbidity and mortality among patients of chronic kidney disease with hemodialysis.

Method: The study was observational with prospective cohort design. It was conducted at Dialysis Installation of Dr. Sardjito Hospital from August 2004 to December 2005. Population were all patients of hemodialysis. Samples were purposively taken using inclusion criteria with as many as 44 minimal samples. Dependent variables were morbidity and mortality. Independent variables  were albumin serum level, age and long time hemodialysis. Data analysis was done in phases, univariable, and then bivariable.

Results: There was association between albumin serum level and morbidity at observation I (p=0.021), observation II (p=0.036), and observation III (p=0.012) which indicated that p<0.05. There was also association between albumin serum level and mortality at observation I (p=0.011), observation II, III and IV (p=0.000) which indicated that p<0.05.

Conclusion: There was association between albumin serum level and morbidity and mortality of chronic kidney disease patients with hemodialysis.


albumin; morbidity; mortality; haemodialysis

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Wolfson M. Assessment of Nutritional Status in End- Stage Renal Disease. Up to date in Medicine 1995.

Ardaya. Manajemen Gagal Ginjal Kronik dalam Pernefri. In: Perhimpunan Nefrologi Indonesia, editor. Nefrologi Klinik Tatalaksana Gagal Ginjal Kronik. Palembang: Perhimpunan Nefrologi Indonesia; 2003.

Hung YM, Lee SJ. Analysis of Early and Late Mor- tality of Chronic Hemodialysis Patients in a Hemodialysis Center of Southern Taiwan. Dialysis & Transplantation 2003; 32(4):198-203.

Kopple JD, Zhu X, Lew NL, Lowrie EG. Body Weight-for-Height Relationship Predict Mortality in Maintenance Hemodialysis Patient. Kidney Int 1999;56:1136–48.

Susetyowati. Pengaruh Konseling dengan Bullet terhadap makanan dan Status Gizi Penderita Gagal Ginjal Kronik dengan Hemodialisis di RS Dr. Sardjito Yogyakarta [tesis]. Yogyakarta: Universitas Gadjah Mada; 2001.

Raharjo JP. Nutrisi pada Gagal Ginjal Kronik yang Didialisis. In: Sidabutar RP, Suhardjono, editors. Gizi pada Gagal Ginjal Kronik Beberapa Aspek Penatalaksanaannya. Jakarta: Perhimpunan Nefrologi Indonesia; 1992.

Lazarus JM. Nutrition in Hemodialysis Patients. Am J Kidney Dis 1993;21(1):99-105.

Hakim RM, Levin N. Malnutrition in Hemodialysis Patients Iseki K, Kawazoe N, Fukiyama K. Serum Albumin is a Strong Predictor of Death in Chronic Dialysis Patients. Kidney Int 1993;44:115-19.

Pollock CA, Ibels LS, Allen BJ. Nutritional Markers and Survival in Maintenance Dialysis Patients. Nephron 1996; 74:625-41.

Lindsay RM, Spanner E. A Hypothesis: The Protein Catabolic Rate is Dependent upon the Type and Amount of Treatment in Dialyzed Uremic Patients. Am J Kidney Dis 1989;13:382–9.

Alvestrand A. Nutritional Requirments of Hemodialysa Patients. In: Mitch WE, Klahr S, editors. Nutr Kidney. 1st ed. Boston; 1988. p.59-79.

Almatsier S. Prinsip Dasar Ilmu Gizi. Jakarta: Gramedia Pustaka Utama; 2003.

Heacock P, Nabel J, Norton P, Heile S, Royse D. An Exploration of the Relationship between Nutritional Status and Quality of Live in Chronic Hemodialysis Patients. J Ren Nutr 1996:6(3);152-7.

Sumandjar T. Status Nutrisi sebagai Salah Satu Faktor Prognostik Penderita Hemodialisis Rutin di Instalasi Dialisis RSUP Dr. Sardjito [tesis]. Yogyakarta: Universitas Gadjah Mada; 2000.

de Araújo IC, Kamimura MA, Draibe SA, Canziani MEF, Sesso R, Cuppari L. Nutritional Parameters and Mortality in Incident Hemodialysis Patients. J Ren Nutr 2006;16(1):27-35.


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