Effect of Curcuminoid versus Diclofenac Sodium on Monocytes Secretion of Tumor Necrosis Factor–α in Knee Osteoarthritis

Vivin Hudiyanti

doi:10.22146/acta interna.3873

Effect of Curcuminoid versus Diclofenac Sodium on Monocytes Secretion of Tumor Necrosis Factor–α in Knee Osteoarthritis

https://doi.org/10.22146/acta%20interna.3873

Vivin Hudiyanti^(1*)

(1)
(*) Corresponding Author

Abstract

ABSTRACT

Background. Tumor Necrosis Factor-α (TNF-α), a pro-inflammatory cytokine produced by monocyte is increased in osteoarthritis synovial fluid. Curcuminoid from Curcuma domestica Val. suppresses the secretion of TNF-α.

Objective. The purpose of this study was to investigate the suppression effect of curcuminoid from Curcuma domestica Val on synovial fluid monocyte’s TNF-α secretion compared to diclofenac sodium in knee osteoarthritis

Methods. A prospective randomized open end blinded evaluation (PROBE) method was applied. Subjects were patients with knee osteoarthritis visiting Rheumatology Clinic Dr. Sardjito Hospital and Wirosaban Hospital Yogyakarta. Curcuminoid 30 mg three times daily or diclofenac sodium 25 mg three times daily were administered for 4 weeks. The level of TNF-α secreted by synovial fluid’s monocytes were measured by ELISA before and after treatment.

Results. A total of 80 subjects were enrolled, 39 subjects on curcuminoid treatment groups and 41 subjects on diclofenac sodium group. Seven subjects were dropped out, 5 from the curcuminoid group and 2 from the diclofenac sodium group. There was a significant decrement of TNF-α level during 4 weeks treatment in both groups (p< 0.001 respectively). There was no significant difference on TNF-α levels between groups (p= 0,237), neither in 50% decrement of TNF-α levels (p= 518).

Conclusion. The effect of curcuminoid in decreasing TNF- α level on patients with osteoarthritis is similar with sodium diclofenac.

Keywords: osteoarthritis-monocyte-TNF-α-curcuminoid-diclofenac sodium

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References

Klippel, J.H. Mediator of Inflamation Tissue Destruction and Repair. In J.H. Klippel, L.J. Crofford, J.H. Stone, C.M. Weyand (eds). Primer on the Rheumatic Diseases. 12th Edt. Arthritis Foundation, Georgia. 2001. pp:51-88.

Soeroso, J., Isbagio, H., Kalim, H., Broto, R., Pramudiyo, R. Osteoarthritis. In A.W. Sudoyo, B. Setiyohadi, I. Alwi, M. Simadibrata, S. Setiati (eds). Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi IV. Fakultas Kedokteran Universitas Indonesia.2006. pp:1205-1211.

Noormartany. Gambaran Petanda Biologi Cairan Tubuh pada Penyakit Osteoatritis. In R. Pramudiyo, R.G. Wachjudi, L. Hamijoyo (eds). Osteoarthritis Course. Bandung. 2005. pp:32-43.

Sharma, P., Singh, N., Singh, V., Shrivastava, A. Bio-Immunology of Osteoarthritis. J Immunol Immunopath. 2002: 4(1&2):20-28.

Faloon, W. Arthritis Update : Drugs That Inhibit COX-2 May Cause Tissue Damage. About Joint Health. 2001:1-6

Departemen Kesehatan (Depkes). Pedoman Penggunaan Obat Opioid dalam Penatalaksanaan Nyeri. Departemen Kesehatan RI Direktorat Jendral Pelayanan Kefarmasian dan Alat Kesehatan. 2002. pp 42.

Ikatan Reumatologi Indonesia (IRA). Panduan diagnosis dan pengelolaan Osteoarthritis. 2004. pp:5-15.

Chainani-Wu, N. Safety and Anti-inflamatory Activity of Curcumin: A Component of Tumeric (Curcuma longa). J Alternat Compl Med. 2003: 9(1):161-168.

Ari, S.L., Strier, L., Kazanov, K., Elkayam, O., Lechtenberg, D., Caspi, D., Arber, N. Curcumin Synergistically Potentiates the Growth-Inhibitory and Pro-Apoptotic Effects of Celecoxib in Osteoarthritis Synovial Adherent Cells. Rheumatology. 2006:5:171-177.

Kertia, N., Sudarsono, Imuno, A.D., Mufrot, Catur, E., Raharjo, P., Asdie, A.H. Pengaruh Pemberian Kombinasi Minyak Atsiri Temulawak dan Ekstrak Kunyit Dibandingkan Dengan Piroksikam Terhadap Angka Leukosit Cairan Sendi Penderita dengan Osteoarthritis Lutut. Majalah Farmasi Indonesia. 2005:16(3):155-161.

Chan, M.M. Inhibition of Tumor Necrosis Factor by Curcumin, a Phytochemical. Biochem Pharmacol. 1995:49(11):1551-1556.

DOI: https://doi.org/10.22146/acta%20interna.3873