The Residue Pro le of Ciprofloxacine in Broiler Muscle and Liver

Abstract

The disadvantages of using antibiotic in broiler are the length of withdrawal time that cause loss production because of prolonged feed consumption and maintenance, and increase the risk of drug residue. The cipro oxacine is a ouroquinolone antibiotic that recommended in poultry therapy because of its effectiveness to gastrointestinal infection. This research focused on the residue left in broiler muscle and liver resulted from therapeutic application of cipro oxacine. The experiment conducted to 30 days old of broiler (n = 28) that received the single dose of 50 mg/ kg body weight cipro oxacin intravenously, meanwhile 3 chickens as control did not inject. After drug injection, 3 chickens of each sampling interval were taken to be sacri ced and to collect the abdominal muscle and liver by necropsy procedure. The intervals collecting samples were h1, h8, d 1, d 3, d5 and d7 after injection. The abdominal muscle and liver were minced, homogenized and extracted, then analyzed using high performance liquid chromatography method. The results showed the uctuated drug levels between intervals, both in muscle and liver. The drug residue level in liver was higher in all intervals compared to muscle. The drug levels in muscle and liver at intervals 1 hour until 7 days post injection were 1.64 ± 0.52 and 7.6 ± 0.60, 3.01 ± 0.06 and 7.15 ± 0.29, 1.31 ± 0.01 and 4.31 ± 0.23, 0.87 ± 0.06 and 7.78 ± 0.35, 1.21 ± 0.07 and 4.01 ± 0.27, 1.18 ± 0.08 and 5.56 ± 0.63 μg/g, respectively. All the levels for both tissues were still above the maximum residue limits according to Indonesian Standard (Standar Nasional Indonesia/SNI). It concluded to prolong the withdrawal time of cipro oxacin application in broiler longer than 7 days, to achieve the safe product to consume.