Effects of Lidocaine Concentration on Streptococcus Mutans Bacteria


Muhammad Wildan Hari Subagya Haryono(1*), Poerwati Soetji Rahajoe(2)

(1) Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia
(2) Universitas Gadjah Mada, Yogyakarta, Indonesia
(*) Corresponding Author


Lidocaine is one of the local anesthetics agents that are frequently used in dentistry. Streptococcus mutan is a gram-positive, facultatively an aerobic bacterium commonly found in human oral cavity. The study aims to find out the effects of Lidocaine concentration against Streptococcus mutans bacteria. The study used experimental design with liquid and solid dilution method to find out bacteriostatic and bacteriocidal effects of Lidocaine concentration. The test bacteria used in the study are the ones, which have been compared with Mcfarland standard solution with 10μCFU/ML concentration. The Lidocaine concentrations were 2%, 1%,
0.5%, 0.25%, 0.125%, 0.0625%, 0.03125%, 0.015625%, and 0.007812%. Kruskal-Wallis and Mann-Whitney methods were used for the statistical test. The result of the study suggests that Lidocaine concentration has effects against Streptococcus mutans bacteria in the concentrations of 2%, 1% and 0.5%, to inhibit bacterial growth (p<0.05), but there was no bacteriocidal potential of Lidocaine concentration against Streptococcus mutans bacteria (p>0.05).


Lidocaine, Streptococcus mutans, anti-bacterial

Full Text:



Kaya K, Dogan B, Gunaydin B, Bozdayi G, Kokten G, Rota S. 2007. Comparison of the anti-cacterial effects of two local anesthethics: Lidocaine and Articaine. Turk J Med Sci 37 (1): 7-10.

Gajraj RJ, Kenny GNC, Gillespie JA, Hodson MJ, Scott NB. 1998. Anti-bacterial activity of lidocaine in mixtures with diprivan, British Journal of Anaesthesia 81: 444-8.

Anonymous. 2007b. using antibiotics and chemical agents to control bacteria, Kaisers Microbiology, http://student.ccbcmd.edu/

courses/bio141/unit2/control/antibio.html on November 21, 2007.

Howe GL, Whitehead FIH. 1990. Local Anaesthesia in Dentistry (Translated) ed. 3. Hipokrates. Jakarta: 25-6.

Goldin AA. 2007. Bacterial Anatomy, Bacterial Anatomy Lecture. http://jeeves.mmg.uci.edu/medmicro/Lectures/assets/1Bacterial%20 on November 26, 2010.

Brock. 2007. Cell Biology http://people.uleth.ca/ ~selibl/Biol3200/CourseNotes/CellBiolCh4.pdf on November 26, 2007.

DOI: https://doi.org/10.22146/theindjdentres.9985

Article Metrics

Abstract views : 1125 | views : 1120


  • There are currently no refbacks.





website statistics


View My Stats