Patofisiologi normal pressure hydrocephalus
https://doi.org/10.22146/bns.v19i1.61894 Rina Marlina Hakiem(1*), Abdul Gofir(2), Sekar Satiti(3)
(1) KSM Saraf, RS PKU Muhammadiyah Mayong Jepara, Jawa Tengah
(2) Departemen Neurologi, Fakultas Kedokteran-Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada, Yogyakarta
(3) Departemen Neurologi, Fakultas Kedokteran-Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
Normal pressure hydrocephalus (NPH) is a condition in which excess cerebrospinal fluid (CSF) occurs in the ventricles, and with normal or slightly elevated cerebrospinal fluid pressure. The prevalence of NPH increases with age. The disease presents in a classic triad of symptoms, which are urinary incontinence, dementia, and gait deviations. NPH is classified into idiopathic NPH (INPH) and secondary NPH (SNPH).
There are several theories proposed as the pathophysiological mechanisms of INPH, SNPH, the pressure that remains normal in the widened ventricle and the mechanism of classical symptoms triad. This literature review aims to explore the pathophysiological aspect of NPH in order to assist neurologist to perform a comprehensive management of NPH.
ABSTRAK
Normal pressure hydrocephalus (NPH) adalah hidrosefalus yang tidak menyebabkan peningkatan tekanan intrakranial. Prevalensi NPH meningkat seiring dengan bertambahnya usia. NPH dapat terjadi dengan berbagai kombinasi atau derajat dari masing-masing elemen trias klinis klasik berupa gangguan cara berjalan, inkontinensia urin dan demensia. NPH diklasifikasikan menjadi NPH idiopatik (INPH) dan NPH sekunder (SNPH).
Terdapat beberapa teori yang diajukan sebagai mekanisme patofisiologi terjadinya INPH, SNPH, tekanan yang tetap normal pada ventrikel yang melebar serta mekanisme terjadinya trias gejala klasik. Tujuan penulisan tinjauan pustaka ini adalah untuk mengkaji literatur tentang patofisiologi NPH sehingga dapat memberikan tambahan pengetahuan bagi para klinisi untuk membantu penanganan NPH secara komprehensif.
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DOI: https://doi.org/10.22146/bns.v19i1.61894
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