The Correlation between Alvarado Score and Histopathological Profile of Appendicitis in Academic Hospital of Universitas Gadjah Mada

Noviana Nugrohowati; Agung Widianto; Zum Zakiyyah Itsnaini; Satya Ulan Indra Mahardhika; Rifa Sulistyani

doi:10.22146/ahj.v4i1.63882

The Correlation between Alvarado Score and Histopathological Profile of Appendicitis in Academic Hospital of Universitas Gadjah Mada

https://doi.org/10.22146/ahj.v4i1.63882

Noviana Nugrohowati^(1*), Agung Widianto⁽²⁾, Zum Zakiyyah Itsnaini⁽³⁾, Satya Ulan Indra Mahardhika⁽⁴⁾, Rifa Sulistyani⁽⁵⁾

(1) Academic Hospital of Universitas Gadjah Mada
(2) Academic Hospital of Universitas Gadjah Mada
(3)
(4) Academic Hospital of Universitas Gadjah Mada
(5)
(*) Corresponding Author

Abstract

Background: Appendicitis is an inflammation of the appendix vermiformis, which is the most common cause of acute abdominal emergency and requires immediate surgical treatment. Anamnesis and clinical examinations in Alvarado score results can be used as early detection to determine further treatment. The use of histopathological examination is to confirm the diagnosis of appendicitis. This study was to determine the correlation between the Alvarado score and the histopathological profile of appendicitis. It assesses appendicitis diagnosis accuracy based on the Alvarado score at the Academic Hospital of UGM.

Methods: This study was a cross-sectional design study with a diagnostic test method using secondary data from 173 appendicitis patients from 1 January to 31 December 2019, who met the inclusion and exclusion criteria.

Results: According to the histopathology result, the finding of acute appendicitis was 95.95%, which Alvarado score of ≥7 was 71.68%. The overall sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of Alvarado score for acute appendicitis were 73.49%, 71.43%, 73.41%, 98.39 %, 10.20%, respectively.

Conclusion: The Alvarado score is a sensitive, specific, and accurate scoring system that functions as a diagnostic tool for acute appendicitis.

Keywords

Alvarado score, Diagnostic tool of acute appendicitis, Histopathological profile of appendicitis, Sensitivity, and Specificity.

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References

Mollie F, Samuel Q, Belle SK, Natalie M, Chad GB, Greg WC, Nij B, Subrata G, Elijah D, Siew N, Gilaad G. 2017. The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies. Ann Surg 266:237–241.

Kementerian Kesehatan Republik Indonesia. 2009. Profil Kesehatan Indonesia. Jakarta: Departemen Kesehatan.

Muttaqin A, Sari K. 2011. Gangguan Gastrointestinal: Aplikasi Asuhan Keperawatan Medikal Bedah, Salemba Medika, Jakarta.

Cathleya F, Gotra, Mahastuti. 2019. Karakteristik Pasien dengan Gambaran Histopatologi Apendisitis Di RSUP Sanglah Denpasar Tahun 2015 – 2017. Jurnal Medika Udayana, Vol. 8 No.7.

RajaShekar J, Uday MM, Naveen N. 2016. Modified Alvarado Score and its Application in the Diagnosis of Acute Appendicitis. International Journal of Contemporary Medical Research Volume 3, Issue 5.

Nirmala, Mysore J, Shahanuma S, Rajendra N. 2018. Evaluation of the Diagnostic Accuracy of Modified Alvarado Scoring System in Comparison to Histopathological Results in Acute Appendicitis. Annals of Pathology and Laboratory Medicine Vol. 5, Issue 1.

Widianto A, Rathariwibowo W, Tomo WK, Sistaparamita R. 2016. Hubungan antara Temuan Klinis, Makroskopis dengan Histopatologis pada Spesimen Apendektomi RS UGM Yogyakarta, RS UGM.

Andi Siswandi. 2015. Gambaran Klinis Pasien Apendisitis Akut dengan Menggunakan Penilaian Tzanakis Skor dan Alvarado Skor di RSUD Dr H Abdul Moeloek Bandar Lampung Tahun 2014. Jurnal Medika Malahayati: Vol 2, No 3: 110 – 114.

Health Grove. 2013. Appendicitis Global Statistics - Mortality, Societal Burden [online]. http://globaldiseases.healthgrove.com/l/152/ Appendicitis.

Widyanita, A, Arini, M, Dewi, A. 2016. Evaluasi Implementasi Clinical Pathway Appendisitis Akut pada Unit Rawat Inap Bagian Bedah di RSUD Panembahan Senopati Bantul.

Petroianu A, Barroso TVV. 2016. Pathophysiology of Acute Appendicitis. JSM Gastroenterology and Hepatology, 4(3).

Alvarado, A. 1986. A practical score for the early diagnosis of acute appendicitis. Annals of Emergency Medicine, 15(5): 557-564.

Baresti, SW dan Tofik R. 2017. Sistem Skoring Baru untuk Mendiagnosis Apendisitis Akut. Majority, Volume 6 (3).

Blair JE and Petras RE. 2010. Differential diagnosis in surgical pathology. 2nd ed. Elsevier.

Goldblum J, Lamps L, McKenney J, Myers J. 2017. Rosai and Ackerman's Surgical Pathology, 11 th edition. Elsevier.

Amalia I. 2016. Gambaran sosio-demografi dan gejala apendisitis akut di RSU Kota Tangerang Selatan. Jakarta: Universitas Islam Negeri Syarif Hidayatullah.

Thomas GA, Lahunduitan I, Tangkilisan A. 2016. Angka kejadian apendisitis di RSUP Prof. Dr, R. D. Kandou Manado periode Oktober 2012 – September 2015. Jurnal e-clinic 4(1):1-16.

Indri U, Karim D, Elita V. 2014. Hubungan Antara Nyeri, Kecemasan Dan Lingkungan Dengan Kualitas Tidur Pada Pasien Post Operasi Apendisitis. Program Studi Ilmu Keperawatan, Universitas Riau.

Sima F, Haskas Y, Darwis D. 2013. Faktor Risiko Kejadian Apendisitis Di Rumah Sakit Umum Daerah Kab. Pangkep Stikes Nani Hasanuddin Makassar.

Craig S. 2017. Appendicitis treatment & management. Medscape.

Garba S, Ahmed A. 2010. Appendicitis in the Elderly. Intechopen, 1;109.

Aydin S, Fatihoglu E, Ramadan H, Akhan B, Koseoglu E. 2017. Alvarado Score, Ultrasound, and CRP: How to Combine Them for the Most Accurate Acute Appendicitis Diagnosis. Iran J Radiol 14(2):e38160.

Ozkan S, Dukan A, Durukan P, Yildirim A, Ozbakan O. 2014. The accuracy rate of Alvarado score, ultrasonography, and computerized tomography scan in the diagnosis of acute appendicitis in our center. Nigerian Journal of Clinical Practice Vol 17 Issue 4.

Sonawane RS, Jatkar GL, Chaudari MS. 2016. Correlation of Alvarado score for acute appendicitis with pathological acute appendicitis. International Surgery Journal. Vol 3 : Issue 3.

Ramadhanti A. 2018. Uji Sensitivitas dan Spesifisitas Skor Alvarado terhadap Kajadian Apendisitis Akut di RSUD Tangerang Selatan Tahun 2015-1026. Jakarta: Universitas Islam Negeri Syarif Hidayatullah.

Al-Hashemy AM, selem MI. 2004. Appraisal of the modified Alvarado score for acute appendicits in adults. Saudi Med J 25:1229‑31.

Shrivastava UK, Gupta A, Sharma D. 2004. Evaluation of the Alvarado score in the diagnosis of acute appendicitis. Trop Gastroenterol 25:184‑6.

DOI: https://doi.org/10.22146/ahj.v4i1.63882