The effects of Curcuma xanthorrhiza rhizome simplicia and Camellia sinensis green tea in a patient with chronic hepatitis B infection: a case report

  • Sjarif Ismail Department of Pharmacology, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia.
  • Ika Fikriah Department of Pharmacology, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia.
  • Nataniel Tandirogang Department of Microbiology, Faculty of Medicine, Mulawarman University. Samarinda, Indonesia
  • Khemasili Kosala Department of Microbiology, Faculty of Medicine, Mulawarman University. Samarinda, Indonesia
Keywords: C. xanthorrhiza rhizome, C. sinensis green tea, chronic hepatitis B, interferon, antiviral


The hepatitis B virus (HBV) causes acute and chronic liver infections which can be treated by using interferon and antiviral. However, the treatment is relatively expensive. We reported here a case of a patient with chronic hepatitis B who had negative seroconversion without interferon (IFN) and antiviral treatment after herbal consumption. A retrospective investigation showed that the patient consumed Curcuma xanthorrhiza rhizome and Camelia sinensis green tea.  These herbs were widely both in vitro and in vivo studied for their effects against HBV infection, although the clinical studies are limited. This case reported the effect of C. xanthorrhiza rhizome and C. sinensis green tea consumption in a patient with chronic hepatitis B. A female patient with chronic hepatisis B infection at the age of 32 y.o. had been taking neuro vitamins regularly for a year before infection detected. She was an asymptomatic patient with normal limits liver function, positive HBsAg and negative anti-Hbs. At the age of 45, she started taking C. xanthorrhiza rhizome simplicia equivalent to 5mg of curcumin twice daily and drinking C. sinensis green tea regularly. Six years later, HBsAg was not detected and her liver function remained within normal limits and Anti-HBs were detected 5 years later. In conclusion, the consumption of C. xanthorrhiza rhizome and C. sinensis green tea can against chronic hepatisis B infection by eliminate HBV dan induce anti-HBs.


Thanigaivel S, Durgadevi H, Rohan N, Mythily V, Elanchezhiyan M. Antihepatitis B virus (HBV) activity of extracts of Camellia sinensis, the green tea. World Res J Med Aromat Plant 2013; 2(1):039-043.

Karamese M, Aydogdu S, Karamese SA, Altoparlak U, Gundogdu C. Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication. Asian Pac J Cancer Prev 2015; 16:4199-202.


Ilene ASP, Sandhika W, Hasanatuludhhiyah N. Effect of Javanese turmeric (Curcuma xanthorrhiza) extract on hepatitis model of alcohol-induced mice. JKB 2020; 31(1):39-42.

Salleh NAM, Ismail S, Halim MRA. Effects of Curcuma xanthorrhiza extracts and their constituents on phase II drug-metabolizing enzymes activity. Pharmacognosy Res 2016; 8(4):309–15. doi: 10.4103/0974-8490.188873

Buonomo AR, Scotto R, Nappa S, Arcopinto M, Salzano A, Marra AM, et al. The role of curcumin in liver diseases. Arch Med Sci 2019; 15(6):1608–20.

Oliveira RMM. Quantification of catechins and caffeine from green tea (Camellia sinensis) infusions, extract, and ready-to-drink beverages. Ciênc Tecnol Aliment Campinas 2012; 32(1):163-6.

Lin CC, Liu WH, Wang ZH, Yin MC. Vitamins B status and antioxidative defense in patients with chronic hepatitis B or hepatitis C virus infection. Eur J Nutr 2011; 50:499-506.

Esrefoglu M. Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis. Hepat Mon 2012; 12(3):160-7. DOI: 10.5812/hepatmon.837

Farzaei MH, Zobeiri M, Parvizi F, El-Senduny FF, Marmouzi I, Coy-Barrera E, et al. Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients 2018; 10:855. doi:10.3390/nu10070855

Wallace, Elizabeth A, Weeks WB. Thiamine treatment of chronic hepatitis B infection. Am J Gastroenterol 2001; 96:864-8.

Lin CC, Yin MC. B vitamins deficiency and decreased anti-oxidative state in patients with liver cancer. Eur J Nutr 2007; 46(5):293–9.

Wei ZQ, Zhang YZ, Ke CZ, Chen HX, Pan R, He YL, et al. Curcumin inhibits hepatitis B virus infection by downregulating cccDNA-bound histone acetylation. World J Gastroenterol 2017; 23(34):6252-60.

Wang YQ, Li QS, Zheng XQ, Lu JL, Liang YR. Review: Antiviral effects of green tea EGCG and its potential application against COVID-19. Molecules 2021; 26:3962.

Reddy MA, Kumar BK, Boobalan G, Reddy MK, Kumar CSVS, Reddy AG, et al. Hepatoprotective potential of green tea extract against experimental hepatotoxicity in rats. Indian J Pharm Sci 2017; 79(1):58-64.

Cao SY, Li BY, Gan RY, Mao QQ, Wang YF, Shang A, et al. The in vivo antioxidant and hepatoprotective actions of selected Chinese teas. Foods 2020; 9:262.


Saklar S, Ertas E, Ozdemir IS, Karadeniz B. Effects of different brewing conditions on catechin content and sensory acceptance in Turkish green tea infusions. J Food Sci Technol 2015; 52(10):6639–46.

Tout I, Loureiro D, Mansouri A, Soumelis V, Boyer N, Asselah T. Hepatitis B surface antigen seroclearance: immune mechanisms, clinical impact, importance for drug development. J Hepatol 2020; 73: 409–22. DOI: 10.1016/j.jhep.2020.04.013

Lau GKK, Suri D, Liang R, Rigopoulou EI, Thomas MG, Mullerova I, et al. Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen. Gastroenterol 2002; 122: 614-24. DOI: 10.1053/gast.2002.31887

Besedovsky L, Lange XT, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev 2019; 99: 1325–80. DOI: 10.1152/physrev.00010.2018

Peake JM, NeubauerO, Walsh NP, Simpson RJ. Recovery of the immune system after exercise. J Appl Physiol 2017; 122: 1077–87. DOI: 10.1152/japplphysiol.00622.2016

Fu YS, Chen TH, Weng L, Huang L, Lai D, Weng CF. Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential. Biomed Pharmacother 2021; 141:111888.

Praditya D, Kirchhoff L, Brüning J, Rachmawati H, Steinmann J, Steinmann E. Anti-infective properties of the golden spice curcumin. Front Microbiol 2019; 10:912. doi: 10.3389/fmicb.2019.00912

Wu S, Xiao D. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol 2016; 117:697-702.